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Review

June 9, 2025


Prospects of Mendelian randomization in hepatology: a comprehensive literature review with practice guidance
Lanlan Chen, Qi Rao, Menghan Gao, et al.
Clin Mol Hepatol. 2025;31(4):1115-1138.

Mendelian randomization (MR), a powerful statistical tool for causal inference, has been widely applied in various fields of medical research, even extending to economics and psychology. In hepatology, MR has...

Review

June 24, 2025


Update in the treatment of cirrhotic patients with portal vein thrombosis
Jialin Wu, Xinyi Deng, Junyang Luo, et al.
Clin Mol Hepatol. 2025;31(4):1139-1166.

Portal vein thrombosis (PVT) is characterized by the formation of a thrombus (blood clot) within the portal vein system, including main portal vein and its intrahepatic portal vein branches, and...

Review

August 4, 2025


Prospects of late-stage development agents in the treatment of metabolic dysfunction-associated steatohepatitis
Brian Lee, Ussama Ghumman, Lisa D. Pedicone, et al.
Clin Mol Hepatol. 2025;31(4):1167-1196.

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a spectrum of pathology involving fatty liver disease that may progress to fibrosis, cirrhosis, hepatocellular carcinoma, and liver failure. The prevalence of MASLD...

Review

July 28, 2025


Global strategies and actions to eliminate hepatitis B virus infection
Chih-Lin Lin, Jia-Horng Kao
Clin Mol Hepatol. 2025;31(4):1197-1212.

Through the implementation of hepatitis B vaccination and effective antiviral treatment over the past four decades, the hepatitis B surface antigen (HBsAg) seroprevalence of the vaccinated generation dramatically decline. The...

Review

August 4, 2025


Taiwan liver cancer association management consensus guidelines for intermediate-stage hepatocellular carcinoma
I-Cheng Lee, Hung-Wei Wang, Wei Teng, et al.
Clin Mol Hepatol. 2025;31(4):1213-1232.

Intermediate-stage hepatocellular carcinoma (HCC) encompasses a diverse patient population that requires individualized treatment strategies and a multidisciplinary approach. Recent advancements in systemic therapy have expanded the therapeutic options for intermediate-stage...

Original Article

December 13, 2024


Plasma lipidomics and fungal peptide-based community analysis identifies distinct signatures for early mortality in acute liver failure
Neha Sharma, Sushmita Pandey, Gaurav Tripathi, et al.
Clin Mol Hepatol. 2025;31(4):1233-1251.

Background/Aims: Acute liver failure (ALF) has high mortality predominantly due to compromised immune system and increased vulnerability to bacterial and fungal infections. Methods: Plasma lipidome and fungal peptide-based community (mycobiome) analysis...

Original Article

June 2, 2025


Genome-wide interaction study with body mass index identifies CYP7A1 and GIPR as genetic modulators of metabolic dysfunction-associated steatotic liver disease
Oveis Jamialahmadi, Endrina Mujica, Lowri Morris, et al.
Clin Mol Hepatol. 2025;31(4):1252-1268.

Background/Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) may progress to liver inflammation, fibrosis, cirrhosis and hepatocellular carcinoma. So far, genome-wide association studies explain a small fraction of MASLD heritability. Methods: We...

Original Article

June 4, 2025


Distinct inflammatory imprint in non-cirrhotic and cirrhotic patients before and after direct-acting antiviral therapy
Moana Witte, Carlos Oltmanns, Jan Tauwaldt, et al.
Clin Mol Hepatol. 2025;31(4):1269-1284.

Background/Aims: Hepatitis C virus (HCV) infection remains a global health challenge, leading to chronic liver disease, cirrhosis, and hepatocellular carcinoma (HCC). Despite the high efficacy of direct-acting antiviral therapy in...

Original Article

June 13, 2025


Non-contrast magnetic resonance imaging for detection of late recurrent hepatocellular carcinoma after curative treatment: a prospective multicenter comparison to contrast-enhanced computed tomography
Dong Wook Kim, Won Chang, So Yeon Kim, et al.
Clin Mol Hepatol. 2025;31(4):1285-1297.

Background/Aims: Hepatocellular carcinoma (HCC) frequently recurs after curative treatment, posing challenges to long-term survival. Although contrast-enhanced multiphasic computed tomography (CECT) is commonly used for detecting recurrence, it is associated with...

Original Article

June 24, 2025


Factors associated with hepatitis B mother-to-child transmission in a national prevention program
Moran Ki, Byung-Woo Kim, Dahye Baik, et al.
Clin Mol Hepatol. 2025;31(4):1298-1315.

Background/Aims: Hepatitis B virus (HBV) mother-to-child transmission (MTCT) remains a global health concern, with over 90% of perinatal infections leading to chronic HBV. To evaluate long-term trends in MTCT rates...

Original Article

July 4, 2025


Human cytomegalovirus reactivation in cirrhosis patients with acute decompensation
Changze Hong, Zuxiong Huang, Yingli He, et al.
Clin Mol Hepatol. 2025;31(4):1316-1332.

Background/Aims: The role of reactivation of human cytomegalovirus (HCMV) in determining outcomes of cirrhotic patients with acute decompensation (AD) is unknown. We aimed to investigate HCMV incidence and potential correlation...

Original Article

August 8, 2025


Hepatocytic ankyrin repeat and SOCS box protein 3 deficiency alleviates metabolic dysfunction-associated steatotic liver disease by decreasing ubiquitin-mediated carnitine palmitoyl transferase 1A
Yuli Lin, Wulei Hou, Mengxiao Ge, et al.
Clin Mol Hepatol. 2025;31(4):1333-1354.

Background/Aims: Excessive lipid accumulation in hepatocytes is a critical cause of metabolic dysfunction-associated steatotic liver disease (MASLD) progression. Ankyrin repeat and SOCS box protein 3 (ASB3) is an E3 ubiquitin...

Original Article

September 1, 2025


Predictive machine learning model in intensive care unit patients with acute-on-chronic liver failure and two or more organ failures
Yee Hui Yeo, Mengyi Zhang, Martin S. McCoy, et al.
Clin Mol Hepatol. 2025;31(4):1355-1371.

Background/Aims: Prediction of short-term mortality in patients with acute-on-chronic liver failure (ACLF) admitted to the intensive care unit (ICU) may enhance effective management. Methods: To develop, explain, and validate a predictive...

Original Article

September 1, 2025


Association of bile acid composition with synthetic pathways and efficacy of bezafibrate in cholestatic liver disease
Manami Iida, Atsuko Higashida, Shuichi Ohtomo, et al.
Clin Mol Hepatol. 2025;31(4):1372-1383.

Background/Aims: Bezafibrate (BZF), a dual peroxisome proliferator-activated receptor/pregnane X receptor agonist, has demonstrated efficacy in combination with ursodeoxycholic acid (UDCA) for primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC)....
Current Issue
Volume 31(4); Oct 2025
CMH Bulletin
The Liver Week 2025 Highlights: Celebrating the 30th Anniversary of the Korean Association for the Study of the Liver
Young Eun Chon, Ju Hyun Shim, Joo Hyun Oh, Jiwon Yang, Hyunjae Shin, Wonseok Kang, Yeongseok Hwang, Su Jong Yu, Jongman Kim, Hae Won Lee, Yoon Jun Kim, Sook-Hyang Jeong
Clin Mol Hepatol. 2025;31(4):1107-1114.   Published online October 1, 2025
View: 664   Download: 29
Review
2271
Prospects of Mendelian randomization in hepatology: a comprehensive literature review with practice guidance
Lanlan Chen, Qi Rao, Menghan Gao, Guoyue Lv, Frank Tacke
Clin Mol Hepatol. 2025;31(4):1115-1138.   Published online June 9, 2025
View: 2971   Download: 201  Crossref: 3
2281
Update in the treatment of cirrhotic patients with portal vein thrombosis
Jialin Wu, Xinyi Deng, Junyang Luo, Zaibo Jiang, Fuda Xie, Bonan Chen, Hoi Wing Leung, Ge Zhang, Ka Fai To, Wei Kang
Clin Mol Hepatol. 2025;31(4):1139-1166.   Published online June 24, 2025
View: 2400   Download: 253  Crossref: 1
2315
Prospects of late-stage development agents in the treatment of metabolic dysfunction-associated steatohepatitis
Brian Lee, Ussama Ghumman, Lisa D. Pedicone, Andres Gomez Aldana, Eric Lawitz
Clin Mol Hepatol. 2025;31(4):1167-1196.   Published online August 4, 2025
View: 3638   Download: 191
2305
Global strategies and actions to eliminate hepatitis B virus infection
Chih-Lin Lin, Jia-Horng Kao
Clin Mol Hepatol. 2025;31(4):1197-1212.   Published online July 28, 2025
View: 2407   Download: 163  Crossref: 1
2316
Taiwan liver cancer association management consensus guidelines for intermediate-stage hepatocellular carcinoma
I-Cheng Lee, Hung-Wei Wang, Wei Teng, Tsung-Jung Lin, Chien-Hung Chen, Hsueh-Chou Lai, Teng-Yu Lee, Ching-Wei Chang, Chao-Hung Hung, Chia-Yen Dai, Yi-Ping Hung, Ying-Chun Shen, Chien-Wei Su, Ming-Chih Ho, Wei-Chen Lee, Gar-Yang Chau, Chin-Tsung Ting, Po-Chin Liang, Chien-An Liu, Pi-Yi Chang, Kuan-Yang Chen, Shi-Ming Lin, Li-Tzong Chen, Yi-Hsiang Huang, TLCA Intermediate Stage HCC Working Group
Clin Mol Hepatol. 2025;31(4):1213-1232.   Published online August 4, 2025
View: 3927   Download: 332
Original Article
2118
Plasma lipidomics and fungal peptide-based community analysis identifies distinct signatures for early mortality in acute liver failure
Neha Sharma, Sushmita Pandey, Gaurav Tripathi, Manisha Yadav, Nupur Sharma, Babu Mathew, Abhishak Gupta, Vasundhra Bindal, Sadam H. Bhat, Yash Magar, Rimsha Saif, Sanju Yadav, Amritpal Kaur, Rakhi Maiwall, Shvetank Sharma, Shiv Kumar Sarin, Jaswinder Singh Maras
Clin Mol Hepatol. 2025;31(4):1233-1251.   Published online December 13, 2024
View: 8958   Download: 239
2265
Genome-wide interaction study with body mass index identifies CYP7A1 and GIPR as genetic modulators of metabolic dysfunction-associated steatotic liver disease
Oveis Jamialahmadi, Endrina Mujica, Lowri Morris, Rosellina Margherita Mancina, Ester Ciociola, Sami F. Qadri, Samantha Maurotti, Francesco Malvestiti, Ruifang Li-Gao, Luisa Ronzoni, Federica Tavaglione, Hannah Maude, Amin Allalou, Anastasia Emmanouilidou, Umberto Vespasiani-Gentilucci, Frits Richard Rosendaal, Hannele Yki-Järvinen, Inês Cebola, Luca Valenti, Marcel den Hoed, Stefano Romeo
Clin Mol Hepatol. 2025;31(4):1252-1268.   Published online June 2, 2025
View: 2958   Download: 213  Crossref: 1
2270
Distinct inflammatory imprint in non-cirrhotic and cirrhotic patients before and after direct-acting antiviral therapy
Moana Witte, Carlos Oltmanns, Jan Tauwaldt, Hagen Schmaus, Jasmin Mischke, Gordon Grabert, Mara Bretthauer, Lennart M. Roesner, Thomas Werfel, Katja Deterding, Benjamin Maasoumy, Heiner Wedemeyer, Tim Kacprowski, Anke R.M. Kraft, Markus Cornberg
Clin Mol Hepatol. 2025;31(4):1269-1284.   Published online June 4, 2025
View: 2033   Download: 102  Crossref: 1
2278
Non-contrast magnetic resonance imaging for detection of late recurrent hepatocellular carcinoma after curative treatment: a prospective multicenter comparison to contrast-enhanced computed tomography
Dong Wook Kim, Won Chang, So Yeon Kim, Young-Suk Lim, Jonggi Choi, Jungheum Cho, Jin-Wook Kim, Jai Young Cho, Sun Kyung Jeon, Yun Bin Lee, Eun Ju Cho, Su Jong Yu, Kyung-Suk Suh, Kwang-Woong Lee, Dong Ho Lee
Clin Mol Hepatol. 2025;31(4):1285-1297.   Published online June 13, 2025
View: 3280   Download: 137
2285
Factors associated with hepatitis B mother-to-child transmission in a national prevention program
Moran Ki, Byung-Woo Kim, Dahye Baik, Jong-Hyun Kim
Clin Mol Hepatol. 2025;31(4):1298-1315.   Published online June 24, 2025
View: 1980   Download: 119
2290
Human cytomegalovirus reactivation in cirrhosis patients with acute decompensation
Changze Hong, Zuxiong Huang, Yingli He, Rongqi Wang, Jiaying Lin, Yushan Liu, Baicheng Liu, Xiaoqin Lan, Qinjun He, Wenfan Luo, Qintao Lai, Ling Zhou, Tingting Qi, Yali Ji, Miaoxia Liu, Qiaoping Wu, Yichen Yao, Weihao Liang, Xianbo Wang, Guohong Deng, Yanhang Gao, Yan Huang, Feng Liu, Xiaobo Lu, Zhongji Meng, Yuemin Nan, Hai Li, Beiling Li, Rajiv Jalan, Jinjun Chen
Clin Mol Hepatol. 2025;31(4):1316-1332.   Published online July 4, 2025
View: 2338   Download: 100
2320
Hepatocytic ankyrin repeat and SOCS box protein 3 deficiency alleviates metabolic dysfunction-associated steatotic liver disease by decreasing ubiquitin-mediated carnitine palmitoyl transferase 1A
Yuli Lin, Wulei Hou, Mengxiao Ge, Zhihao Wu, Linlin Huang, Haoye Liu, Wenli Zhang, Xiyu Deng, Lanxin Wang, Ming Guan, Chunhua Song, Zuoyun Wang, Dongqin Yang
Clin Mol Hepatol. 2025;31(4):1333-1354.   Published online August 8, 2025
View: 3228   Download: 414
2337
Predictive machine learning model in intensive care unit patients with acute-on-chronic liver failure and two or more organ failures
Yee Hui Yeo, Mengyi Zhang, Martin S. McCoy, Jian Zu, Yingli He, Yi Liu, Juan Li, Taotao Yan, Yuan Wang, Hirsh D. Trivedi, Ju Dong Yang, Vinay Sundaram, Xiaodan Sun, Zhujun Cao, Chun-Ying Wu, Jonel Trebicka, Fanpu Ji
Clin Mol Hepatol. 2025;31(4):1355-1371.   Published online September 1, 2025
View: 2673   Download: 317
2338
Association of bile acid composition with synthetic pathways and efficacy of bezafibrate in cholestatic liver disease
Manami Iida, Atsuko Higashida, Shuichi Ohtomo, Akihito Takeuchi, Ryo Miura, Yoshinari Asaoka, Naoshi Horiba, Akira Honda, Atsushi Tanaka
Clin Mol Hepatol. 2025;31(4):1372-1383.   Published online September 1, 2025
View: 1911   Download: 162
Snapshot
2314
Decoding platelet function in liver cirrhosis: A shift from quantity to quality
Vibhuti Jakhmola, Sukriti Baweja, Chhagan Bihari
Clin Mol Hepatol. 2025;31(4):1384-1386.   Published online July 29, 2025
View: 2013   Download: 51
Erratum
Erratum to ‘Current burden of MASLD, MetALD, and hepatic fibrosis among US adults with prediabetes and diabetes, 2017–2023’ [Clin Mol Hepatol 2025;31:e235-e238]
Donghee Kim, Rohit Loomba, Aijaz Ahmed
Clin Mol Hepatol. 2025;31(4):1387-1388.   Published online October 1, 2025
View: 457   Download: 4

Clinical and
Molecular
Hepatology

Print ISSN: 2287-2728
Online ISSN: 2287-285X

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