Clinical and Molecular Hepatology
publishes original basic and clinical research on liver diseases. Manuscripts should be submitted electronically (http://submit.e-cmh.org/
). The journal is published in English on 1st in January, April, July,
Authors lacking ability with English syntax should seek the appropriate editorial assistance prior to submitting their manuscripts.
These guidelines are in accordance with the “Uniform Requirements for Manuscripts Submitted to
Biomedical Journals,” published by the International Committee of Medical Journal Editors at
The Editorial Office,
Clinical and Molecular Hepatology
Room A1210, Mapo Trapalace, 53 Mapo-daero, Mapo-gu, 04158, Seoul, Korea
Tel.: 82-2-703-0051, Fax: 82-2-703-0071, E-mail: firstname.lastname@example.org
Contributions may be submitted as original articles, case reports, review articles, editorials and special topics. Special topics cover guidelines, meeting reports and hepatology issues elsewhere. Review articles, editorials and special topics are invited by the editorial board. However, authors who are interested in contributing reviews can submit reviews and are subjected to peer review. Letters to the editor may be subjected to peer review and undergo editing for clarity and brevity.
All investigations involving human participants must be conducted according to the ethical guidelines of the Declaration of Helsinki, and be approved by the institutional review board. For studies involving animal experimentation, author(s) must provide assurance that all the animals received humane care according to the criteria outlined in the NIH "Guide for the Care and Use of Laboratory Animals". The author must state that the use of animals (means all mammals and birds) in the manuscript was approved by the institutional Animal Ethical Committee (AEC) in accordance to the article 14th
of Korean Animal Protection Law, or equivalent, in the paper. It must be clearly stated that animal use has complied to the article 13th
of Korean Animal Protection Law (The principles of animal use) and the relevant institutional polices in the manuscript. Copies of the protocol approved by institutional AEC or equivalents, must be available for review by the editor if necessary.
The corresponding author must give written assurance that neither the submitted material nor portions thereof have been published previously or are under consideration for publication elsewhere. Any material that could constitute prior or concurrent publication of similar data by any one of the authors should be submitted with the manuscript. It is assumed that the corresponding author speaks for his or her co-authors and certifies that all the listed authors meaningfully participated in the study and that they have seen and approved the final manuscript.
Authors should acknowledge any commercial affiliation or consultancy that could be constructed as potential conflicts of interest under a heading “Conflict of Interest statement” prior to the references.
For the policies on the research and publication ethics not stated in this instructions, ‘Good Publication Practice Guidelines for Medical Journals ( https://www.kamje.or.kr/board/view?b_name=bo_publication&bo_id=7&per_page=
)’or ‘Guidelines on good publication ( http://www.publicationethics.org.uk/guidelines
)’ can be applied.
Ensure correct use of the terms sex (when reporting biological factors) and gender (Identity, psychosocial or cultureral factors), and, unless inappropriate, report the sex and/or gender of study participants, the sex of animals or cells, and describe the methods used to determine sex and gender.
If the study was done involving an exclusive population, for example in only one sex, authors should justify why, except in obvious cases, (e.g., prostate cancer).
Authors should define how they determined race or ethnicity and justify their relevance.
The manuscript should be written in A4 (21×30 cm) paper in double space texts by leaving 3 cm space in the right, left, top and bottom sides at 10 point fonts.
Original manuscripts describing clinical and basic studies in the field of hepatology. Manuscripts are expected to be well-organized and clearly written. They should not exceed 6,000 words, including the abstract, references, tables, and figure legends. No more than 8 figures and tables, with a maximum of 6 panels per figure. It is permitted for you to submit additional methodological details, non-essential figures or portions of your manuscript as supplementary material for online publication only. References cited in the main text may not be listed in the supplementary materials. The only references be listed in the supplement are those cited exclusively in the supplement. References should not exceed a maximum of 50.
Original article must arranged as follows: (1) title page (2) abstract (250 words or less with a list of 5 or less key words), (3) introduction, (4) materials and methods (or patients and methods), (5) results, (6) discussion, (7) acknowledgements, (8) conflict of interest statement (9) references, (10) tables, and (11) figure legends.
Review articles on selected topics of interest for the readers of the Clinical and Molecular Hepatology and will be solicited by the Editors. Review articles are expected to be clear, concise and updated. The maximum length is 5,000 words. The inclusion of a maximum of 8 high quality tables and/or colored figures to summarize critical points is highly desirable.
This section consists of invited brief editorial comments on articles published in the Clinical and Molecular Hepatology . The length of an editorial should not exceed 1,500 words and 1 table or 1 figure is allowed. References should not exceed a maximum of 20.
Case reports are not encouraged and will only be accepted if they represent an outstanding contribution to the etiology, pathogenesis or treatment of a specific liver disease. The length of a case report should not exceed 3,000 words. A total number of 2 tables or figures is allowed. References should not exceed a maximum of 10.
Case reports consist of (1) title page, (2) abstract (150 words or less with a list of 5 or less key words) (3) introduction, (4) cases, (5) discussion, (6) references (20 or less), (7) tables and figure legends and (8) figures (5 or less) on separate pages.
Letters to the editor
Letters to the editor should be related to a recent article published in the Clinical and Molecular Hepatology within previous two years, or interesting case report that author wants to report. Letters to the editor must arranged as follows: (1) title page, (2) body (3) references (maximum of 15), and (4) a maximum number of 4 tables or figures is allowed. There are no word limits, but authors are encouraged to report within 2,500 words. Abstract is not required.
Special topics should be no longer than 3,000 words (including references) and 10 or less references.
1. Title page
Provide a concise title. List the full names of all authors and their institutional affiliation. In a multi-authored work involving more than a single institution, indicate individual affiliation by means of superscript Arabic numbers. Indicate a change of address in a similar fashion. List the footnotes to the title page. Provide the contact information for the corresponding author (name, address, telephone number, fax number, e-mail address and Orcid ID), and running title (Less than 50 characters). All abbreviations should be explained in this page (e.g. AFP, alpha fetoprotein; ALT, alanine aminotransferase). Clinical and Molecular Hepatology employs a system to screen plagiarism (CrossRef). When submitting your manuscript to this journal, you accept that your manuscript may be screened for plagiarism against previously published material.
Abstract of original articles must contain 250 words or less and must be organized as follows: Backgrounds/Aims, Methods, Results, and Conclusions
. Five or less key words from MeSH terms (http://www.nlm.nih.gov/mesh/meshhome.html
) should be provided at the end of the abstract.
Abstract of case reports must contain 150 words or less in unstructured form.
Authors of original articles are requested to include “Highlights” which consist of three to four sentences summarizing the originality and main findings of the article. “Highlights” should not exceed 100 words in total. Highlights must be organized in a box and placed after the end of the abstract. The authors are encouraged to include the “Highlights” with initial article submission. When submitting a revised manuscript, the submission of the “Highlights” is mandatory.
Provide a level of detail such that another investigator could repeat the work. For methods that are used without significant modification, citation of the original work will suffice. Identify and provide references for all the statistical methods used.
5. Results and Discussion
Present the major findings of the study in graphical form if practicable. Do not illustrate minor details if their message is adequately conveyed by simple descriptive text. Mention all the tables and figures. In the discussion, concisely present the implications of the new findings for the field as a whole, minimizing any reiteration of the results and avoid repetition of material in the introduction; keeping a close focus on the specific topic of the paper.
An acknowledgement of persons who made a genuine assistance and provided special reagents may be included. Grant and financial support related with the work should be specifically stated.
7. Authors’ contribution
Based on the ICMJE guidelines for authorship criteria, how each author has contributed to the paper should be clarified (e.g, Conception or design of the work, Data collection, Data analysis and interpretation, Drafting the article, Critical revision of the article, and Final approval of the version to be published).
References should be numbered in the order they are cited, and the number of reference should be marked in the text by means of a superscript Arabic numerical. Only literature that is published or in press (with the name of the publication) may be numbered and listed; abstracts and letters to the editor may be cited, but they must be less than 3 years old and identified as such.
Cite the names of all authors when there are six or less; when seven or more list the first six followed by et al.
Articles in journals
1. Kim YS, Jung ES, Hur W, Bae SH, Choi JY, Song MJ, et al. Noninvasive predictors of nonalcoholic steatohepatitis in Korean patients with histologically proven nonalcoholic fatty liver disease. Clin Mol Hepatol 2013;19:120-130.
2. Chung C, Iwakiri Y. The lymphatic vascular system in liver diseases: its role in ascites formation. Clin Mol Hepatol 2013;19:99-104.
Literature in press
An online article that has not yet been published in an issue can be cited by its Digital Object Identifier (DOI). The DOI will remain valid and allow an article to be tracked even after its allocation to an issue. Wong GL. Management of chronic hepatitis B patients in immunetolerant phase: what latestguidelines recommend. Clin Mol Hepatol. 2018Jan 22. doi: 10.3350/cmh.2017.0068.
1. Gumucio JJ, Berkowitz CM. Structural organization of the liver and function of the hepatic acinus. In: Kaplowitz N, ed. Liver and Biliary Diseases. Vol I. 2nd ed. Baltimore: Williams & Wilkins, 1992:2-17.
Abstract or Article in a supplement
1. Cho YJ, Lee SH, Kim BH, Yang SK, Jo YH, Lee DH. Characteristics of hepatocellular carcinoma with reference to ages in Korean patients [Abstract]. Hepatology 1998;28:246A.
2. Bellentani S, Marino M. Epidemiology and natural history of non-alcoholic fatty liver disease (NAFLD). Ann Hepatol 2009;8(Suppl 1):S4-S8.
1. Ontario Chronic Disease Prevention Alliance (OCDPA). Economic cost of chronic disease in Canada 1995-2003. OCDPA web site, <http://www.ocdpa.on.ca/OCDPA/docs/OCDPA_EconomicCosts.pdf
>. Accessed 7 Sep 2011.
Direct quotations, tables or illustrations taken from copy-righted material must be accompanied by written permission for their use from the publisher. The permission is presented as a footnote or addition to the legend and it must provide complete information as to the source. Photographs of identifiable persons must be accompanied by a signed release that indicates their informed consent.
Standard abbreviations not requiring definition are those listed in the Journal of Clinical Investigation. Otherwise, do not abbreviate unless a term is used more than five times in a paper. In this case, the abbreviation should be spelled out, in its first use in the text with the abbreviated form in parentheses, and it should also be listed on the footnote page (see above). Abbreviations used in figures or tables should be defined in the legend. Radiation measurements and laboratory values should be in accordance with the International System of Units (SI) (resources: “SI Units in Radiation Protection and Measurements, NCRP Report no. 82” [August 1985]; “Now Read This: The SI Units Are Here,” JAMA 1986;255:2329-2339).
11. Drug names
Use generic names. The proprietary name may be mentioned in parenthesis. The names and locations (city and state or country) of manufacturers should be included in parentheses when mentioning proprietary drugs, tools, instruments, software, etc.
Prepare tables on individual sheets of paper, double spaced and numbered consecutively with Arabic numerals in the order of their appearance in the text. The title of tables should be written concisely in clauses and phrases. The first letter of the table title starts with a capital letter. Explain all abbreviations and symbols such as *, †, ‡, §, ∥, , **, ††, ‡‡, §§. Do not duplicate the material presented in a figure.
13. Figure legends
Number the figures with Arabic numerals in the order they are mentioned in the text. Provide a title (this should not appear on the figure itself) and sufficient explanation to render the figure intelligible without reference to the text. For any copyrighted material, indicate that permission has been obtained (see Permissions, above). Figure legends should be typed consecutively on a separate sheet of paper.
Illustrations should be sharp and presented in the PPT format at the time of submission. They should be less than 10 MB in size for electronic upload. Figures should be supplied in the JPG or TIFF format at a final resolution of not less than 600 dpi. Please provide an image file on CD or Webhard with the assistance of The Editorial Office when it is larger than 10 MB. Microscopic pictures should be explained according to the staining method and scaled by the power of magnification. Authors are charged for color figures.
The journal utilizes blind peer-review in evaluating manuscripts for publication. Submitted papers will be reviewed by at least two referees, and decisions will be available in approximately one month. With respect to the revision and resubmission of manuscripts, it is the journal's policy to allow a couple of resubmission only, which should be received within 2 months from the time of receipt of the initial review letter. In general, a manuscript requiring more than a couple of revision or returned beyond 2 months will be handled as a new submission. The journal does not have article submission charges. Only when the articles are accepted for publication, domestic corresponding authors are charged for their original articles, brief communications and clinical case reports, which is 6,000 Won (Korean Currency) per page. Page charge is waived for international contributors (corresponding author from outside of Korea), and is reimbursed for domestic contributors.
Copyright for all material published in Clinical and Molecular Hepatology is vested in The Korean Association for the Study of the Liver. In accordance with the Copyright Act, all manuscripts must be accompanied by a Copyright transfer form signed by all authors and that follows these guidelines. Statements and opinions expressed in the articles and communications in Clinical and Molecular Hepatology are those of the author(s) and do not necessarily reflect the opinions of the Editor(s) or publisher, and the Editor(s) and publisher disclaim any responsibility or liability for such material. Neither the Editor(s) nor the publisher guarantees, warrants or endorses any product or service advertised in the journal; nor do they guarantee any claim made by the manufacturer of such product or service