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Review

March 2, 2022


The emerging roles of extracellular vesicles as intercellular messengers in liver physiology and pathology
Youngseok Lee, Jong-Hoon Kim
Clin Mol Hepatol. 2022;28(4):706-724.

Extracellular vesicles (EVs) are membrane-enclosed particles released from almost all cell types. EVs mediate intercellular communication by delivering their surface and luminal cargoes, including nucleic acids, proteins, and lipids, which...

Review

March 14, 2022


Old and new classes of glucose-lowering agents as treatments for non-alcoholic fatty liver disease: A narrative review
Lei Miao, Jing Xu, Giovanni Targher, et al.
Clin Mol Hepatol. 2022;28(4):725-738.

Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease with a global prevalence of about 55% in people with type 2 diabetes mellitus (T2DM). T2DM, obesity...

Review

April 26, 2022


Prediction models of hepatocellular carcinoma recurrence after liver transplantation: A comprehensive review
Sang Jin Kim, Jong Man Kim
Clin Mol Hepatol. 2022;28(4):739-753.

Liver transplantation (LT) is one of the most effective treatments for hepatocellular carcinoma (HCC). Although LT eliminates HCC and greatly reduces recurrence, some patients experience recurrence after LT. Criteria and...

Review

April 21, 2022


Deep learning-based prediction of molecular cancer biomarkers from tissue slides: A new tool for precision oncology
Sung Hak Lee, Hyun-Jong Jang
Clin Mol Hepatol. 2022;28(4):754-772.

Molecular tests are necessary to stratify cancer patients for targeted therapy. However, high cost and technical barriers limit the application of these tests, hindering optimal treatment. Recently, deep learning (DL)...

Review

August 8, 2022


Impact of diabetes, obesity, and dyslipidemia on the risk of hepatocellular carcinoma in patients with chronic liver diseases
Hwang Sik Shin, Baek Gyu Jun, Sang-Wook Yi
Clin Mol Hepatol. 2022;28(4):773-789.
Despite the increasing prevalence of metabolic disorders, the potential effects of metabolic factors on hepatocellular carcinoma (HCC) development in individuals with chronic liver diseases (CLDs) are not well understood. For...

Review

May 11, 2022


Nonalcoholic fatty liver disease versus metabolic-associated fatty liver disease: Prevalence, outcomes and implications of a change in name
Cheng Han Ng, Daniel Q. Huang, Mindie H. Nguyen
Clin Mol Hepatol. 2022;28(4):790-801.

Nonalcoholic fatty liver disease (NAFLD) affects about a third of the world’s adult population and is a major public health concern. NAFLD is defined by the presence of hepatic steatosis...

Original Article

June 9, 2022


The usefulness of metabolic score for insulin resistance for the prediction of incident non-alcoholic fatty liver disease in Korean adults
Jun-Hyuk Lee, Kyongmin Park, Hye Sun Lee, et al.
Clin Mol Hepatol. 2022;28(4):814-826.

Background/Aims: The early detection and prevention of non-alcoholic fatty liver disease (NAFLD) has been emphasized considering the burden of this disease. Both hepatic and peripheral insulin resistances are strongly associated...

Original Article

June 22, 2022


Auranofin attenuates hepatic steatosis and fibrosis in nonalcoholic fatty liver disease via NRF2 and NF- κB signaling pathways
Seung Min Lee, Dong Hee Koh, Dae Won Jun, et al.
Clin Mol Hepatol. 2022;28(4):827-840.

Background/Aims: We aim to evaluate the effects of auranofin, a known antioxidant, on hepatic steatosis, inflammation, and fibrosis, contributing to non-alcoholic steatohepatitis (NASH) development in vivo and in vitro. Methods: Transcriptome...

Original Article

September 19, 2022


Forecasted 2040 global prevalence of nonalcoholic fatty liver disease using hierarchical bayesian approach
Michael H. Le, Yee Hui Yeo, Biyao Zou, et al.
Clin Mol Hepatol. 2022;28(4):841-850.

Background/Aims: Due to increases in obesity and type 2 diabetes, the prevalence of nonalcoholic fatty liver disease (NAFLD) has also been increasing. Current forecast models may not include non-obese NAFLD....

Original Article

June 3, 2022


Impact of nationwide hepatocellular carcinoma surveillance on the prognosis in patients with chronic liver disease
Won Sohn, Danbee Kang, Minwoong Kang, et al.
Clin Mol Hepatol. 2022;28(4):851-863.

Background/Aims: This study aimed to investigate the effect of hepatocellular carcinoma (HCC) surveillance using the Korea National Liver Cancer Screening Program on the receipt of curative treatment for HCC and...

Original Article

July 25, 2022


Global prevalence of depression and anxiety in patients with hepatocellular carcinoma: Systematic review and meta-analysis
Darren Jun Hao Tan, Sabrina Xin Zi Quek, Jie Ning Yong, et al.
Clin Mol Hepatol. 2022;28(4):864-875.

Background/Aims: Depression and anxiety are associated with poorer outcomes in patients with hepatocellular carcinoma (HCC). However, the prevalence of depression and anxiety in HCC are unclear. We aimed to establish...

Original Article

September 19, 2022


Impacts of muscle mass dynamics on prognosis of outpatients with cirrhosis
Tae Hyung Kim, Young Kul Jung, Hyung Joon Yim, et al.
Clin Mol Hepatol. 2022;28(4):876-889.

Background/Aims: Sarcopenia negatively affects the prognosis of cirrhotic patients, but clinical implications of changes in muscle mass remain unclear. We aimed to elucidate its role in the prognosis of outpatients...

Original Article

June 3, 2022


COVID-19 vaccine immunogenicity among chronic liver disease patients and liver transplant recipients: A meta-analysis
Ka Shing Cheung, Chiu Hang Mok, Xianhua Mao, et al.
Clin Mol Hepatol. 2022;28(4):890-911.

Background/Aims: Data of coronavirus disease 2019 (COVID-19) vaccine immunogenicity among chronic liver disease (CLD) and liver transplant (LT) patients are conflicting. We performed meta-analysis to examine vaccine immunogenicity regarding etiology,...

Original Article

July 28, 2022


Decreased vitamin D-binding protein level portends poor outcome in acute-on-chronic liver failure caused by hepatitis B virus
Daxian Wu, Qunfang Rao, Zhongyang Xie, et al.
Clin Mol Hepatol. 2022;28(4):912-925.

Background/Aims: Acute-on-chronic liver failure (ACLF) is a catastrophic illness. Few studies investigated the prognostic value of vitamin D-binding protein (VDBP) for hepatitis B virus (HBV)-related ACLF (HBV-ACLF) resulted in conflicting...
Current Issue
Volume 28(4); Oct 2022
Guideline
1713
2022 KLCA-NCC Korea practice guidelines for the management of hepatocellular carcinoma
Clin Mol Hepatol. 2022;28(4):583-705.   Published online October 1, 2022
View: 1583   Download: 182
Review
1666
The emerging roles of extracellular vesicles as intercellular messengers in liver physiology and pathology
Youngseok Lee, Jong-Hoon Kim
Clin Mol Hepatol. 2022;28(4):706-724.   Published online March 2, 2022
View: 9033   Download: 168  Citations: 3
1668
Old and new classes of glucose-lowering agents as treatments for non-alcoholic fatty liver disease: A narrative review
Lei Miao, Jing Xu, Giovanni Targher, Christopher D Byrne, Ming-Hua Zheng
Clin Mol Hepatol. 2022;28(4):725-738.   Published online March 14, 2022
View: 1731   Download: 171  Citation: 1
1674
Prediction models of hepatocellular carcinoma recurrence after liver transplantation: A comprehensive review
Sang Jin Kim, Jong Man Kim
Clin Mol Hepatol. 2022;28(4):739-753.   Published online April 26, 2022
View: 1319   Download: 85  Citation: 1
1673
Deep learning-based prediction of molecular cancer biomarkers from tissue slides: A new tool for precision oncology
Sung Hak Lee, Hyun-Jong Jang
Clin Mol Hepatol. 2022;28(4):754-772.   Published online April 21, 2022
View: 1328   Download: 141  Citations: 2
Impact of diabetes, obesity, and dyslipidemia on the risk of hepatocellular carcinoma in patients with chronic liver diseases
Hwang Sik Shin, Baek Gyu Jun, Sang-Wook Yi
Clin Mol Hepatol. 2022;28(4):773-789.   Published online August 8, 2022
View: 1549   Download: 145
1678
Nonalcoholic fatty liver disease versus metabolic-associated fatty liver disease: Prevalence, outcomes and implications of a change in name
Cheng Han Ng, Daniel Q. Huang, Mindie H. Nguyen
Clin Mol Hepatol. 2022;28(4):790-801.   Published online May 11, 2022
View: 1811   Download: 274  Citations: 8
Editorial
Screening and prediction of nonalcoholic fatty liver disease using a peripheral insulin resistance index: Potential benefits and limitations
Soon Sun Kim, Jae Youn Cheong
Clin Mol Hepatol. 2022;28(4):802-805.   Published online September 14, 2022
View: 623   Download: 44
1701
Repurposing drugs to target nonalcoholic steatohepatitis: Auranofin, a gold-organic molecule complex for the treatment of a specifc complex trait
Carlos J. Pirola, Silvia Sookoian
Clin Mol Hepatol. 2022;28(4):806-809.   Published online August 19, 2022
View: 600   Download: 32
Surveillance for hepatocellular carcinoma: It is time to move forward
Bo Hyun Kim, Yuri Cho, Joong-Won Park
Clin Mol Hepatol. 2022;28(4):810-813.   Published online September 6, 2022
View: 615   Download: 46
Original Article
1685
The usefulness of metabolic score for insulin resistance for the prediction of incident non-alcoholic fatty liver disease in Korean adults
Jun-Hyuk Lee, Kyongmin Park, Hye Sun Lee, Hoon-Ki Park, Jee Hye Han, Sang Bong Ahn
Clin Mol Hepatol. 2022;28(4):814-826.   Published online June 9, 2022
View: 1296   Download: 114  Citation: 1
1688
Auranofin attenuates hepatic steatosis and fibrosis in nonalcoholic fatty liver disease via NRF2 and NF- κB signaling pathways
Seung Min Lee, Dong Hee Koh, Dae Won Jun, Yoon Jin Roh, Hyeon Tae Kang, Ju Hee Oh, Hyun Sung Kim
Clin Mol Hepatol. 2022;28(4):827-840.   Published online June 22, 2022
View: 1791   Download: 165  Citation: 1
1712
Forecasted 2040 global prevalence of nonalcoholic fatty liver disease using hierarchical bayesian approach
Michael H. Le, Yee Hui Yeo, Biyao Zou, Scott Barnet, Linda Henry, Ramsey Cheung, Mindie H. Nguyen
Clin Mol Hepatol. 2022;28(4):841-850.   Published online September 19, 2022
View: 805   Download: 67
1682
Impact of nationwide hepatocellular carcinoma surveillance on the prognosis in patients with chronic liver disease
Won Sohn, Danbee Kang, Minwoong Kang, Eliseo Guallar, Juhee Cho, Yong-Han Paik
Clin Mol Hepatol. 2022;28(4):851-863.   Published online June 3, 2022
View: 1268   Download: 81  Citation: 1
1694
Global prevalence of depression and anxiety in patients with hepatocellular carcinoma: Systematic review and meta-analysis
Darren Jun Hao Tan, Sabrina Xin Zi Quek, Jie Ning Yong, Adithya Suresh, Kaiser Xuan Ming Koh, Wen Hui Lim, Jingxuan Quek, Ansel Tang, Caitlyn Tan, Benjamin Nah, Eunice Tan, Taisei Keitoku, Mark D. Muthiah, Nicholas Syn, Cheng Han Ng, Beom Kyung Kim, Nobuharu Tamaki, Cyrus Su Hui Ho, Rohit Loomba, Daniel Q. Huang
Clin Mol Hepatol. 2022;28(4):864-875.   Published online July 25, 2022
View: 1232   Download: 47
1711
Impacts of muscle mass dynamics on prognosis of outpatients with cirrhosis
Tae Hyung Kim, Young Kul Jung, Hyung Joon Yim, Joo Won Baik, Sun Young Yim, Young-Sun Lee, Yeon Seok Seo, Ji Hoon Kim, Jong Eun Yeon, Kwan Soo Byun
Clin Mol Hepatol. 2022;28(4):876-889.   Published online September 19, 2022
View: 734   Download: 70
1683
COVID-19 vaccine immunogenicity among chronic liver disease patients and liver transplant recipients: A meta-analysis
Ka Shing Cheung, Chiu Hang Mok, Xianhua Mao, Ruiqi Zhang, Ivan FN Hung, Wai Kay Seto, Man Fung Yuen
Clin Mol Hepatol. 2022;28(4):890-911.   Published online June 3, 2022
View: 1469   Download: 100
1695
Decreased vitamin D-binding protein level portends poor outcome in acute-on-chronic liver failure caused by hepatitis B virus
Daxian Wu, Qunfang Rao, Zhongyang Xie, Xiaoqing Zhu, Yuanmei Che, Jian Wu, Hainv Gao, Jingyu Zhang, Zhouhua Hou, Xiaoyu Cheng, Zeyu Sun
Clin Mol Hepatol. 2022;28(4):912-925.   Published online July 28, 2022
View: 1005   Download: 103
Letter to the Editor
1702
Autoimmune liver disease represented as primary biliary cholangitis after SARS-CoV-2 infection: A need for population-based cohort study
Soon Kyu Lee, Jung Hyun Kwon, Nara Yoon, Soon Woo Nam, Pil Soo Sung
Clin Mol Hepatol. 2022;28(4):926-928.   Published online September 5, 2022
View: 610   Download: 36  Citation: 1
Forms of cholangitis to be considered after SARS-CoV-2 infection
Ju-Yeon Cho, Young-Sun Lee, Soon Sun Kim, Do Seon Song, Jeong-Hoon Lee, Ji Hoon Kim
Clin Mol Hepatol. 2022;28(4):929-930.   Published online September 8, 2022
View: 542   Download: 28
1704
Non-alcoholic fatty liver disease and the risk of dementia: A meta-analysis of cohort studies
Li-Yu Lu, Min-You Wu, Yung-Shuo Kao, Cheng-Hsien Hung
Clin Mol Hepatol. 2022;28(4):931-932.   Published online September 5, 2022
View: 706   Download: 61
Non-alcoholic fatty liver disease and risk of dementia: Unmet need for a pooled analysis of cohort studies
Seogsong Jeong, Won Kim, Sang Min Park
Clin Mol Hepatol. 2022;28(4):933-934.   Published online September 14, 2022
View: 655   Download: 35
Snapshot
1689
Personalized medicine in nonalcoholic fatty liver disease
Carlos J. Pirola, Silvia Sookoian
Clin Mol Hepatol. 2022;28(4):935-938.   Published online June 24, 2022
View: 1013   Download: 82
Erratum
Erratum to ‘History and future of hepatitis B virus control in South Korea’ [Clin Mol Hepatol 2021;27:620-622]
Do Young Kim
Clin Mol Hepatol. 2022;28(4):939-939.   Published online June 24, 2022
View: 755   Download: 21
Erratum to ‘KASL clinical practice guidelines for management of chronic hepatitis B’ [Clin Mol Hepatol 2022;28:276-331]
Clin Mol Hepatol. 2022;28(4):940-940.   Published online September 7, 2022
View: 616   Download: 28

Clinical and
Molecular
Hepatology

Print ISSN: 2287-2728
Online ISSN: 2287-285X

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