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Korean J Hepatol > Volume 5(3); 1999 > Article
The Korean Journal of Hepatology 1999;5(3): 200-207.
만성 C형 간질환 환자에서 자가항체의 발현 빈도와 임상적 의의 ( Prevalence and Clinical Significance of Autoantibodies in Patients with Chronic Hepatitis C )
Prevalence and Clinical Significance of Autoantibodies in Patients with Chronic Hepatitis C
Byung Cheol Song,Soo Hyun Yang,Young Hwa Chung,Yung Sang Lee,Dong Jin Suh
Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea

Chronic hepatitis C virus (HCV) infection is often associated with extrahepatic autoimmune disease, and autoantibodies such as anti-nuclear antibody (ANA) or anti-smooth muscle antibody (ASA). The presence of autoantibodies may make discrimination between chronic hepatitis C with autoimmune features and type 1 autoimmune hepatitis difficult. We studied the prevalence of autoantibodies in patients with chronic HCV infection and their clinical significance.
Materials and Methods
: ANA, ASA, anti-mitochondrial antibody (AMA), anti-microsomal antibody (AmA), rheumatoid factor (RF), anti-cardiolipin antibody (aCL) and lupus anti-coagulant (LA) were tested in 116 patients (80 chronic hepatitis C, 36 liver cirrhosis). Genotypes of HCV were determined in 25 patients by INNO LiPA.
The overall prevalence of autoantibody was 65.5%. The most common autoantibody was aCL (34.5%), followed by ANA (25%), RF (18%), LA (15.5%), ASA (6.9%), anti-microsomal antibody (6%) and AMA (1%). The positive rate of either ANA or ASA was 30.2%, but both were positive in 1.7% only. There was no difference in the demographic features, biochemistry, HCV genotypes and disease status between autoantibody-positive and autoantibody-negative patients.
Autoantibodies were commonly found in patients with chronic HCV infection. But, the presence of autoantibodies may be a non-specific finding in chronic hepatitis C infection without clinical significance. (Korean J Hepatol 1999;5:200-207)
KeyWords: Autoantibody, Hepatitis C virus
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