Korean J Hepatol > Volume 12(2); 2006 > Article
The Korean Journal of Hepatology 2006;12(2): 154-162.
Action Mechanism in Immunopathogenesis and Clearance of HBV
Se Jin Im , Young Chul Sung
POSTECH, Cellular Immunology Lab
ABSTRACT
Hepatitis B virus (HBV) currently infects more than 400 million people worldwide and they are at risk of developing chronic liver disease, cirrhosis and hepatocellular carcinoma. The immune response to HBV- encoded antigens is responsible both for viral clearance and for disease pathogenesis during HBV infection. While the humoral antibody response to viral envelope antigens contributes to the clearance of circulating virus particles, the cellular immune responses to the envelope, nucleocapsid, and polymerase antigens were known to eliminate virus in infected hepatocytes through cytolytic as well as noncytolytic mechanisms. Liver injury could be initiated by an immune response against HBV, but mainly resulted from HBV non-specific lymphocytes and macrophages. There are growing evidences that T helper 1 memory T cells play a predominant role in suppressing viral replication mainly by IFN-γ through noncytolytic antiviral mechanism. Elucidation of the immunological and virological basis for HBV infection may yield effective immunotherapeutic and antiviral strategies to terminate chronic HBV infection. (Korean J Hepatol 2006;12: 154-162)
KeyWords: Hepatitis B virus; Hepatitis B, acute; Hepatitis B, chronic; Immunity, cellular; T lymphocytes
TOOLS
METRICS Graph View
  • 2,756 View
  • 48 Download
Related articles

Editorial Office
The Korean Association for the Study of the Liver
Room A1210, 53 Mapo-daero(MapoTrapalace, Dowha-dong), Mapo-gu, Seoul, 04158, Korea
TEL: +82-2-703-0051   FAX: +82-2-703-0071    E-mail: kasl@kams.or.kr
Copyright © The Korean Association for the Study of the Liver.         
COUNTER
TODAY : 491
TOTAL : 1841414
Close layer