Clinical Significance of Serum Concentration of Intercelluar Adhesion Molecule - 1 in Patients with Acute and Chronic Liver Disease

Korean J Hepatol > Volume 2(1); 1996 > Article

The Korean Journal of Hepatology 1996;2(1): 68-76.

원저 : 급성 및 만성 간질환에서 혈청 Intercelluar Adhesion Molecule - 1 측정의 의의 ( Original Articles : Clinical Significance of Serum Concentration of Intercelluar Adhesion Molecule - 1 in Patients with Acute and Chronic Liver Disease )

Clinical Significance of Serum Concentration of Intercelluar Adhesion Molecule - 1 in Patients with Acute and Chronic Liver Disease

Sung Shick Lim , Seok Ho Dong , Hyo Jong kim , Byung Ho Kim , Rin Chang , Joung Il Lee

ABSTRACT

Baekground/Aims:Recent studies, have examined the expression of adhesion molecules in liver inflammation, and the existence of soluble ICAM 1 in serum could be proved by ELISA. We maeasured s-ICAM 1 in patients with acute and ehronic liver disease to see the level of s-ICAM 1 can reflect degree of necroinflammation or progress of disease. Method:Serum levels of soluble forms of intercellular adhesion molecule 1(sIGAM 1) in 78 patients with acute and chronic liver disease including acute hepatitis B, CAH, C.'PH, post-necrotic and alcoholic liver cirrhosis, hepatoceliular carcinoma, toxic hepatitis were measured by enzyme-linked immunosorbent assays. Results.l> ICAM 1 semm levels in acute and chronic liver disease including acute hepatitis B(709.6+ 321.7 ng/L, p<0.001), C:AH(582.2+ 312.4 ng/L, p<0.001), CPH(357,8+ 135.0 ngL, p<0.044), postnecrotic livercirrhosis(716.2+ 348.0 ng/L, p<0.0001), alcoholic liver cirrhosis(763.3+ 48l.5 ng/L, p<0.009). Hepatocellular carcinoma(728.2+ 329.0 ng/L, p<0.002), toxic hepatitis(817.3+ 324.4 ng/l, p<0.0001) were signiticantly higher than that of healthy controLs(234.5+ 67.5 ng/L). 2> In comparison with CPH we found significantly increased ICAM- 1 serum levels in CAH.(p=0.027) A significant correlation was found between the ICAM-1 serum level and the histologically graded inflammatory activity in CAH. 3>No correlation was found be1ween the ICAM l serum level aml the Child- Pugh classification in liver cirrhosis. 4>In comparison with chronic hepatitis we found signitcantly increased 1CAM 1 serum levels in liver cirrhosis(p = 0.001) , and in hepatocellular carcinoma(p = 0.0001), Conclusion:Soluble ICAM I serum level correlated well with ongoing necrointlammatory activity in acute and chronic hepatitis and also slCAM 1 can reflect disease severity in various chronic 1iver disease groups.

KeyWords: ICAM - 1 , acute and chronic liver disease