Korean J Hepatol > Volume 8(4); 2002 > Article
The Korean Journal of Hepatology 2002;8(4): 355-362.
Relation of Apolipoprotein E Polymorphism to Clinically Diagnosed Fatty Liver Disease
Dong Min Lee , Seung Ok Lee , Byoung Sik Mun , Heok Soo Ahn , Hye Young Park* , Hye Soo Lee* , Dae Ghon Kim
Departments of Internal Medicine, Laboratory Medicine*, Chonbuk National University College of Medicine, Chonju, Korea
Apolipoprotein E (Apo E) is important in plasma lipid metabolism and is a component of several plasma lipoprotein-lipid particles. Three major Apo E isoforms are encoded by three common allelic forms, ε2, ε3, and ε4 at the APO E locus. The goal of this study was to examine the association between polymorphisms in the apolipoprotein E gene (APOE) and fatty liver disease. Methods: We examined the distribution of APOE alleles from 116 fatty liver patients and 50 controls in Korea. Results: The frequencies of APOE alleles in fatty liver patients were 6.5% in ε2, 85.7% in ε3 and 7.8% in ε4. The corresponding frequencies in control subjects were 4.0% in ε2, 91.0% in ε3 and 5.0% in ε4. There were no significant differences in the distribution of APOE genotypes between fatty liver patients and controls. APOE ε2 and ε4 allele frequencies in fatty liver patients were more than those in controls. However, there was no significant differences in APOE ε2 and ε4 allele frequencies. Conclusions: These results suggest that APOE alleles seem not to be directly associated with the pathogenesis of fatty liver disease. (Korean J Hepatol 2002;8:355-362)
KeyWords: Fatty liver, Apolipoprotein E gene, Polymorphism, Body mass index
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