A Case of Acute Cholestatic Hepatitis Associated with Orlistat

Korean J Hepatol > Volume 8(3); 2002 > Article

The Korean Journal of Hepatology 2002;8(3): 317-320.

증례 : Orlistat 복용과 관련된 급성 담즙정체성 간염 유발 증례 ( Case Reports : A Case of Acute Cholestatic Hepatitis Associated with Orlistat )

A Case of Acute Cholestatic Hepatitis Associated with Orlistat

Doh Hyun Kim , Eun Hee Lee , Jae Chul Hwang , Jai Hak Jeung , Jae Youn Cheong Sung Won Cho , Young Bae Kim

Department of Gastroenterology and Histopathology*, Ajou University College of Medicine, Suwon, Korea

ABSTRACT

Orlistat(Xenical®, Roche) is considered a safe and effective drug to treat obesity by reduced absorption of 30% digested fat. To date, no serious adverse effects affecting the liver have been published except a case of subacute hepatic failure leading to liver transplantation in a young women with moderate obesity treated with orlistat. We report a case of acute cholestatic hepatitis in a young woman with moderate obesity treated with orlistat: a 33-year-old female admitted for the evaluation of jaundice. Abdominal ultrasonography, ERCP, routine chemistry, viral markers, and a fine needle biopsy of liver were performed. Microscopic findings of the liver biopsy specimen were compatible with acute cholestatic hepatitis. After steroid therapy, liver function was improved. (Korean J Hepatol 2002;8:317-320)

KeyWords: Orlistat, Acute cholestatic hepatitis, Side effect