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Korean J Hepatol > Volume 7(4); 2001 > Article
The Korean Journal of Hepatology 2001;7(4): 475-484.
원저 : 개의 부분 간 이식 시 Lipo-PGE1 이 허혈 - 재관류 손상 및 혈중 Endothelin-1 농도에 미치는 ( Original Articles : The Effect of Lipo-PGE1 on Ischemia - Reperfusion Injury and Endothelin-1 Concentrations After Canine Partial Liver Transplantation )
The Effect of Lipo-PGE1 on Ischemia - Reperfusion Injury and Endothelin-1 Concentrations After Canine Partial Liver Transplantation
Ki Youl Seo, M.D., Il-Hwan Moon, M.D., Kwon Yoo, M.D., Hye Kyung Jung, M.D., Ku Yong Chung, M.D.*, and Kum Ja Choi, M.D.*
Department of Internal Medicine and General Surgery* Ewha Womans University Hospital, Seoul, Korea
Abstract
Background / Aim : The lipo-PGE1, known for being more stable during pulmonary circulation and having more targeting effect, has been reported to inhabit ET-1 induced stellate cell contraction. We assessed the effect of lipo-PGE1 on the change of ET-1 concentration and the relationship between ET-1 concentration and the liver damage.
Method
: Mongrel dogs weighting about 25kg were divided into a control(n=6) and a lipo-PGE1 (n=6)group. Partial liver allotransplantation was performed. In the lipo-PGE1 group, lipo-PGE1 was slowly infused (60 ㎍/day) for 48 hours after reperfusion. The AST,ALP,LDH and ET-1 concentrations were monitored Results : The AST and ALP levels of the lipo-PGE1 group were significantly lower than those of the control group both at 1 hour and 48 hours after reperfusion. The LDH level in the lipo-PGE1 group was lower at 1 hour and 48 hours after reperfusion. But there was no statistical difference between the two groups. The baseline ET-1 concentration was elevated gradually in the control group. There was no significant difference between the two groups at 48 hours. There was no correlation between ET-1 concentrations and AST , ALP,LDH levels.
Conclusion
: This study demonstrated the hepatoprotective effect of the lipo-PGE1 against ischemia-reperfusion injury in canine partial liver allotransplantation. However, the baseline ET-1 level was eight tomes higher in the lipo-PGE1 group than that of the comntrol group in spite of the hepatoprotective effects of the lipo-PGE1. (Korean J Hepatol 2001;7 :475- 484)
KeyWords: Transplantation/Liver/Partial liver transplantation, Ischemia- reperfusion injury, Lipo-PGE1, Endothelin- 1
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