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Korean J Hepatol. 2002;8(3):317-320. Published online January 1, 1970.
- A Case of Acute Cholestatic Hepatitis Associated with Orlistat
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- Abstract
- Orlistat(Xenical®, Roche) is considered a safe and effective drug to treat obesity by reduced absorption of 30% digested fat. To date, no serious adverse effects affecting the liver have been published except a case of subacute hepatic failure leading to liver transplantation in a young women with moderate obesity treated with orlistat. We report a case of acute cholestatic hepatitis in a young woman with moderate obesity treated with orlistat: a 33-year-old female admitted for the evaluation of jaundice. Abdominal ultrasonography, ERCP, routine chemistry, viral markers, and a fine needle biopsy of liver were performed. Microscopic findings of the liver biopsy specimen were compatible with acute cholestatic hepatitis. After steroid therapy, liver function was improved. (Korean J Hepatol 2002;8:317-320)
Keywords :Orlistat, Acute cholestatic hepatitis, Side effect
