Mucinous Cholangiocarcinoma associated with Clonorchis sinensis Infestation: A Case Report

Korean J Hepatol > Volume 10(3); 2004 > Article

The Korean Journal of Hepatology 2004;10(3): 223-227.

Mucinous Cholangiocarcinoma associated with Clonorchis sinensis Infestation: A Case Report

Hyo Sup Shim*, Beom Jin Lim*, Myeong-Jin Kim , Woo Jung Lee , Chanil Park*, , and Young Nyun Park*,

Department of Pathology and Brain Korea 21 project for Medical Sciences*, Diagnostic Radiology , Surgery , and Institute of Gastroenterology , Yonsei University College of Medicine, Seoul, Korea

ABSTRACT

Mucinous cholangiocarcinoma, characterized by large quantities of mucin production, is a rare subtype of peripheral cholangiocarcinoma and usually shows rapid progression and a fatal outcome. We report here a case of mucinous cholangiocarcinom a in a 69 year-old man, who was infected with Clonorchis sinensis. Histologically, the tumor was an adenocarcinom a with extensive intracellular and extracellular mucin production, up to 70% of the tumor mass and there was frequent lymphovascular invasion of the tumor cells. The liver adjacent to the mass contained eggs of C lonorchis sinensis in the bile duct lumen and showed ductal epithelial hyperplasia, mucinous metaplasia and adenomatous proliferation of intramural glands. The patient was treated with a right hepatectomy. Four months after the surgery, the tumor recurred in the soft tissue of the right flank. (Korean J Hepatol 2004;10:223-227)

KeyWords: Cholangiocarcinoma, Mucin, Clonorchis sinensis