Combined Hepatocellular and Cholangiocarcinoma , Separate Type - A Case Report

Korean J Hepatol > Volume 7(2); 2001 > Article

The Korean Journal of Hepatology 2001;7(2): 201-205.

증례 : 분리형 혼합 간세포 - 담관상피암종 - 1 예 보고 ( Combined Hepatocellular and Cholangiocarcinoma , Separate Type - A Case Report )

Combined Hepatocellular and Cholangiocarcinoma , Separate Type - A Case Report

Ho Sung Park, Jeong Min Lee*, Hee Chul Yu†, Woo Sung Moon

Department of Pathology, Radiology*, Surgery†, and Institute for medical science, Chonbuk National University Medical School, Jeonju, Korea

ABSTRACT

Combined hepatocellular and cholangiocarcinoma (cHCC-CC) is an uncommon form of primary liver cancer having features of both hepatocellular and billiary epithelial differentiation. We report a case of cHCC-CC that separately developed in a patient who was serologically positive for hepatitis B virus. A 36-year-old woman was diagnosed by ultrasonography with an asymptomatic tumor in the left lobe of the liver. Based on radiologic and serologic findings of elevated serum alpha-fetoprotein (AFP) level, a preoperative diagnosis of hepatocellular carcinoma was made. A left lobectomy of the liver was done. On histological examination, the resected tumor was shown to consist of two separated masses. One was hepatocellular carcinoma that showed immunoreactivity for AFP. The other was cholangio- carcinoma that showed immunoreactivity for cytokeratin-19 (CK-19) in a separate form. (Korean J Hepatol 2001;7:201-205)

KeyWords: Neoplasm/Liver/Hepatocellular carcinoma, Cholangiocarcinoma, Combined hepatocellular and cholangiocarcinoma