| 원저 : 만성 B형 바이러스성 간염에 대한 Thymomodulin 경구요법의 효과 ( Original Articles : Evaluation of Oral Thymomodulin Effect on the Patients with Chronic Viral Hepatitis B ) |
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| Evaluation of Oral Thymomodulin Effect on the Patients with Chronic Viral Hepatitis B |
| Chul Hun Chung , Soong Hwan Lee , Yong Hyeon Jo , Yeon Soo kim , Seung Woo Nam , Oh Young Lee , Dong Soo Ha , Joo Hyun Sohn , Dong Hoo Lee |
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| ABSTRACT |
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Background/Aims
As one of biological modifiers of immune reaction, thymomodulin is known to be peptide derivatives of thyrnic acid. Lysate, and thymomodulin can stimulate antibody formations by increasmg the functions of B and T tymphocytes. Furthermore, GM-CSF and TNF can be released by thymomodulin resulting in relief from bone marrow suppression. And these actions of thymomodulin affer a new therapeutic modality in chronic diseases ot the liver as well as chronic hronchitis. Although interferons are frequently under trials for chronic viral hepatitis B. anothersome of side etTec ts and cost effectiveness is often refractory to be used. Herein, this study was intended to estimate the effectiveness and side effects of per oral thymomodulin. Methods:Forty one patients with chronic viral hepatitis showing positivity of HBsAg over 6 months were treated with per oral !hymomodulin (15mlAmg/ml, h vice daily, over 6 months ), Clinical data of preand post-trial states were prospectively investigated, Results as a result, negative conversion of HBV DNA izvealed 20.6% out ol 34 patients showed HBsAg positivity. HBeAg was isappeared in 10.4 % among the 29 cases. Only two cases were shown the clearance of HBsAg. However. These data are statistically insignificant in comparison to the control group (p>0.05, chi-square test). The desirable effects were noticed as disappearance of acne in 5 cases, and amelioration of menstrual abnormalities in 3 cases. Undesirable side effects were only mild nausea in 3 cases, and indigestion in 2 cases. Conclusions:On thc basis of these data, it is suggested that oral thymomodulin is an easy and safe therapeutic approach in chronic viral hepatitis B but remains to be heralded by long-term clinical trials. |
| KeyWords:
Chronic Viral Hepatitis B , Thymomodulin |
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