Improved Child-Pugh Score after Lamivudine Treatment in Patients with Decompensated Cirrhosis Due to Hepatits B Virus Infection

Korean J Hepatol > Volume 6(4); 2000 > Article

The Korean Journal of Hepatology 2000;6(4): 481-487.

원저 / B형 간염 바이러스 감염과 연관된 비대상성 간경변증 환자에서 라미부딘 치료에 의한 Child-Pugh 점수의 호전 ( Improved Child-Pugh Score after Lamivudine Treatment in Patients with Decompensated Cirrhosis Due to Hepatits B Virus Infection )

Improved Child-Pugh Score after Lamivudine Treatment in Patients with Decompensated Cirrhosis Due to Hepatits B Virus Infection

Moon Suk Choi,Seung Woon Baek,Sang Jong Park,Joon Hyuk Lee,Gwang Chul Ko,Poong Ryul Lee,Jae Joon Kim,Jong Chul Lee,Gyu Wan Choi

Division of Gastroenterology, Samsung Medical CenterSungkyunkwan University School of Medicine, Seoul, Korea

ABSTRACT

Background/Aims
Lamivudine is an oral nucleoside analogue with potent antiviral activity against HBV inducing normalization of ALT and improvement of necro-inflammation and fibrosis in chronic hepatitis B. But its role in decompensated cirrhosis has not been established. The Child-Pugh score is a reliable and convenient prognostic indicator reflecting liver synthetic function. We evaluated the incidence of any improvement in Child-Pugh score after lamivudine treatment in patients with decompensated cirrhosis. Methods: Twenty-six patients with HBV associated active decompensated cirrhosis showing detectable serum HBV received lamivudine (100 or 150 mg/day) for 6-45 months (median 16). The Child-Pugh score at 6th month of lamivudine treatment was compared with base line score. Results: The Child-Pugh score improved ( 2-point reduction) in 17 (65.4%) patients, was constant in 8 (30.8%), and aggravated ( 2-point increase) in one (3.8%) of 26 patients. HBV DNA was initially cleared in 24 cases (92.3%) but breakthrough developed in 7 (29.2%). HBeAg was lost in 5 (25%) of 20 cases. Initial improvement was maintained in 14 (82.4%) of 17 cases but aggravated with breakthrough in 3 (17.6%). Two of 5 patients waiting for liver transplantation showed marked improvement and were removed from the list. Conclusion: Lamivudine can be an effective treatment for patients with decompensated cirrhosis due to HBV infection, improving the Child-Pugh score in many cases. However, deterioration of liver function associated with DNA breakthrough was an important problem in patients showing initial improvement.

KeyWords: HBV, Cirrhosis, Child- Pugh score, Lamivudine