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Korean J Hepatol. 2010;16(2):176-181. Published online June 25, 2010.
DOI: https://doi.org/10.3350/kjhep.2010.16.2.176
- Deficiencies in proteins C and S in a patient with idiopathic portal hypertension accompanied by portal vein thrombosis
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- Abstract
- Portal vein thrombosis (PVT) is an uncommon cause of presinusoidal portal hypertension. Among various hepatoportal disorders, noncirrhotic portal hypertension conditions such as idiopathic portal hypertension (IPH) are considered to have a close relation with PVT. PVT is known to have several predisposing conditions, including infection, malignancies, and coagulation disorders. There is growing interest and recognition that deficiencies in proteins C and S are associated with a hypercoagulable state. These deficiencies are regarded as key factors of systemic hypercoagulability and recurrent venous thromboembolism. We report the case of a 19-year-old male diagnosed as IPH with PVT and combined deficiencies in proteins C and S.
Keywords :Portal hypertension; Thrombosis; Protein C deficiency; Protein S deficiency
