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Korean J Hepatol. 2001;7(4):475-484. Published online January 1, 1970.
- The Effect of Lipo-PGE1 on Ischemia - Reperfusion Injury and Endothelin-1 Concentrations After Canine Partial Liver Transplantation
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- Abstract
- Background
/ Aim : The lipo-PGE1, known for being more stable during pulmonary circulation and having more targeting effect, has been reported to inhabit ET-1 induced stellate cell contraction. We assessed the effect of lipo-PGE1 on the change of ET-1 concentration and the relationship between ET-1 concentration and the liver damage. Methods : Mongrel dogs weighting about 25kg were divided into a control(n=6) and a lipo-PGE1 (n=6)group. Partial liver allotransplantation was performed. In the lipo-PGE1 group, lipo-PGE1 was slowly infused (60 ㎍/day) for 48 hours after reperfusion. The AST,ALP,LDH and ET-1 concentrations were monitored Results : The AST and ALP levels of the lipo-PGE1 group were significantly lower than those of the control group both at 1 hour and 48 hours after reperfusion. The LDH level in the lipo-PGE1 group was lower at 1 hour and 48 hours after reperfusion. But there was no statistical difference between the two groups. The baseline ET-1 concentration was elevated gradually in the control group. There was no significant difference between the two groups at 48 hours. There was no correlation between ET-1 concentrations and AST , ALP,LDH levels. Conclusion : This study demonstrated the hepatoprotective effect of the lipo-PGE1 against ischemia-reperfusion injury in canine partial liver allotransplantation. However, the baseline ET-1 level was eight tomes higher in the lipo-PGE1 group than that of the comntrol group in spite of the hepatoprotective effects of the lipo-PGE1. (Korean J Hepatol 2001;7 :475- 484)
Keywords :Transplantation/Liver/Partial liver transplantation, Ischemia- reperfusion injury, Lipo-PGE1, Endothelin- 1
