| A Case of Combined Hepatocellular-Cholangiocarcinoma with Sarcomatous Transformation and Second Primary Colon Cancer |
| Jae Hi Kim, M.D., Yong Gu Lee, M.D., Jun Lee, M.D., Cheol Kweon Jung, M.D.,
Hyeong Tae Kim, M.D., Haeyoun Kang, M.D.*, Kwang Hyun Kho, M.D., Sung Pyo Hong, M.D.,
Seong Gyu Hwang, M.D., Pil Won Park, M.D. and Gyu Sung Rim, M.D. |
| Departments of Internal Medicine and Pathology*, College of Medicine, Pochon CHA University |
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| ABSTRACT |
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Combined hepatocellular-cholangiocarcinoma is a rare form of primary liver cancer, featuring both hepatocellular and biliary epithelial differentiations. An intrahepatic tumor may be considered as a metastatic lesion. It has been suggested in the literature that the likelihood of metastasis in the cirrhotic liver is lower than that in the non-cirrhotic liver. A rare case of combined hepatocellular-cholangiocarcinoma and second primary colon adenocarcinoma in a 67-year-old male patient with liver cirrhosis is presented. Histologically, the intrahepatic mass was composed of a spindle cell sarcomatous component; a hepatocellular carcinoma component; and a cholangiocarcinoma component. There were focal transitional regions among the different components. Immunohistochemically, the cholangiocarcinoma component of the intrahepatic mass showed positive reaction for CK-7 but negative reactions for CK-20. The adenocarcinoma of the colon showed positive reactions for CK-20 but negative reactions for CK-7. (Korean J Hepatol 2004;10:142-147) |
| KeyWords:
Neoplasm/Liver/Combined hepatocellular-cholangiocarcinoma, Colon neoplasms, Second primary cancer |
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