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Korean J Hepatol > Volume 16(2); 2010 > Article
The Korean Journal of Hepatology 2010;16(2): 187-191.
doi: https://doi.org/10.3350/kjhep.2010.16.2.187
Occurrence of diabetic ketoacidosis and autoimmune thyroiditis in a patient treated with pegylated interferon-alpha 2b and ribavirin for chronic hepatitis C
Yun Nah Lee, M.D., Soung Won Jeong, M.D., Jae Hee Lim, M.D., Yang Seon Ryu, M.D., Seong Ran Jeon, M.D., Sang Kyun Kim, M.D., Jae Young Jang, M.D., Young Seok Kim, M.D., Boo Sung Kim, M.D., Mi Oh Roh, M.D.1
Institute for Digestive Research, Endocrinology, 1Department of Internal Medicine, Soonchunhyang University College of Medicine, Seoul, Korea
Abstract
Combined pegylated interferon and ribavirin therapy for chronic hepatitis C infection cause a wide range of side effects, including flu-like syndrome, hematological abnormalities, cardiovascular symptoms, gastrointestinal symptoms, pulmonary dysfunction, depression, and retinopathy. Interferon-alpha has been shown to be related to the development of various autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, autoimmune thyroid disease, and type 1 diabetes mellitus (DM). Type 1 DM and thyroid disease respectively develop in 0.08~2.61% and 10~15% of patients treated with combined interferon-alpha and ribavirin for chronic hepatitis C. The coexistence of type 1 DM and autoimmune thyroiditis was rarely reported. We report a case of a 33-year-old female patient with chronic hepatitis C who simultaneously developed diabetic ketoacidosis and autoimmune thyroiditis after treatment with pegylated interferon-alpha 2b and ribavirin.
KeyWords: Hepatitis C, chronic; Interferon Alfa-2b; Diabetes Mellitus, type 1; Thyroiditis, autoimmune
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