Abstract
Background/Aims
Transient elastography as performed using the FibroscanⓇ is a useful noninvasive method for evaluating hepatic fibrosis. However, recent studies have found that liver stiffness measurement (lSM) values are inappropriately elevated in acute hepatitis or in the acute flare state of chronic hepatitis, suggesting that the lSM value obtained by the FibroscanⓇ is not a reliable marker for fibrosis. We retrospectively evaluated the clinical factors influencing the lSM value obtained using transient elastography as performed using the FibroscanⓇ in patients with chronic liver disease. Methods: A total of 298 patients who were followed in Kungpook National University Hospital from November 2007 to May 2008 due to previously established liver cirrhosis or chronic liver disease were investigated using the FibroscanⓇ, laboratory test, ultrasound, and/or abdominal computed tomography. Results: The 298 patients were aged 47.8±12.9 years (mean±SD). The cut-off value for a diagnosis of liver cirrhosis was 12.5 kPa (as used in previous studies). Thirty-six patients (15%) and 202 patients (85%) with chronic liver disease without clinical manifestation of cirrhosis had lSMs of >12.5 kPa and <12.5 kPa, respectively. Multivariate analysis revealed that lSM values were unusually increased in patients with chronic liver disease who were older (P=0.007) or who had increased gamma gultamyltranspetidase (GGT) (P=0.022), decreased albumin (P=0.015), or increased total bilirubin (P=0.009). Conclusions: This study reveals that age, GGT, and albumin are clinical factors influencing lSM values. This reinforces the need to interpret lSM values in the context of a defined diagnosis, biochemical data, radiologic examination, and other clinical findings.
Citations
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- A sequential approach using the age‐adjusted fibrosis‐4 index and vibration‐controlled transient elastography to detect advanced fibrosis in Korean patients with non‐alcoholic fatty liver disease
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Alimentary Pharmacology & Therapeutics.2022; 55(8): 994. CrossRef - The Diagnostic value of FibroScan for the degree of liver fibrosis in patients with ALT<2×ULN chronic hepatitis B
Wenjian Shi, Tuanjie Che, Chun Li, Caidong Li, Yan Zhang, Xiaoling Li, Zhong Jia, Hong Wan
Global Journal of Medical and Clinical Case Reports.2020; 7(1): 030. CrossRef - Analysis on Usefulness of Non-invasive Liver Fibrosis Evaluation Method according to the Liver Disease : Focused on H ep atitis C p atients
Nam Ji-Hee, Kim Jung-Hoon
Journal of Radiological Science and Technology.2019; 42(5): 345. CrossRef - Relationship between 25-Hydroxyvitamin D Levels and Liver Fibrosis as Assessed by Transient Elastography in Patients with Chronic Liver Disease
Bong Jin Ko, Young Seok Kim, Sang Gyune Kim, Jung Hwan Park, Sae Hwan Lee, Soung Won Jeong, Jae Young Jang, Hong Soo Kim, Boo Sung Kim, Sun Mi Kim, Young Don Kim, Gab Jin Cheon, Bo Ra Lee
Gut and Liver.2016; 10(5): 818. CrossRef - Liver stiffness and portal blood flow modifications induced by a liquid meal consumption: pathogenetic mechanisms and clinical relevance
Michele Barone, Andrea Iannone, Natale Daniele Brunetti, Francesco Sebastiani, Onofrio Cecere, Elsa Berardi, Gianfranco Antonica, Alfredo Di Leo
Scandinavian Journal of Gastroenterology.2015; 50(5): 560. CrossRef - The factors associated with longitudinal changes in liver stiffness in patients with chronic hepatitis B
In Ku Yo, Oh Sang Kwon, Jin Woong Park, Jong Joon Lee, Jung Hyun Lee, In Sik Won, Sun Young Na, Pil Kyu Jang, Pyung Hwa Park, Duck Joo Choi, Yun Soo Kim, Ju Hyun Kim
Clinical and Molecular Hepatology.2015; 21(1): 32. CrossRef - Early on‐treatment change in liver stiffness predicts development of liver‐related events in chronic hepatitis B patients receiving antiviral therapy
Beom K. Kim, Hyun J. Oh, Jun Y. Park, Do Y. Kim, Sang H. Ahn, Kwang H. Han, Yehyun Park, Eun J. Yoo, Young N. Park, Seung U. Kim
Liver International.2013; 33(2): 180. CrossRef - Clinical applications of transient elastography
Kyu Sik Jung, Seung Up Kim
Clinical and Molecular Hepatology.2012; 18(2): 163. CrossRef
