Abstract
Background/Aims
According to recent prevalence of hepatitis A virus (HAV) infection, acute liver failure ALF) due to HAV infection is observed frequently in parallel. The aim of this study was to elucidate the clinical, laboratory, and pathologic features of patients who have undergone emergency liver transplantation (LT) due to fulminant HAV infection. Methods: Clinical, laboratory, and pathologic data of 11 transplant recipients with anti-HAV IgM-positive ALF between December 2007 and May 2009 were analyzed, and compared with data of 10 recipients who underwent LT for the management of ALF due to other causes. Results: The median age of the patients with HAV-related ALF was 34 years (range: 15-43 years). The levels of hemoglobin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and creatinine were higher and the level of bilirubin was lower in the HAV-related ALF group than in the other group (P=0.005, 0.001, 0.001, 0.010, and 0.003, respectively). The time from the onset of initial symptoms to the development of encephalopathy was shorter in the HAV-related ALF group than in the other group (median 5 days, range: 4-13 days; P<0.001). In patients with HAV-related ALF, laboratory findings and clinical prognostic parameters including the Acute Liver Failure Study Group prognostic index, King`s College criteria, and model for endstage liver disease (MELD) and Child-Pugh scores were not associated with the grade of hepatic encephalopathy or time of progression to encephalopathy. Conclusions: The results of this study indicate that the clinical condition of patients with HAV-related ALF requiring emergency LT aggravates rapidly. Prognostic parameters are not sufficient for discriminating transplant candidates in patients with fulminant hepatitis A. (Korean J Hepatol 2010;16:19-28)
Citations
Citations to this article as recorded by
- Severity of the clinical presentation of hepatitis A in five European countries from 1995 to 2014
Ettore Severi, Leonidas Georgalis, Roan Pijnacker, Lamprini Veneti, Iulia Adelina Turiac, Flaminia Chiesa, Caterina Rizzo, Domenico Martinelli, Line Vold, Bernardo Guzman Herrador, Carmen Varela Martinez, Elena Vanessa Martinez Sanchez, Jan C. Semenza, Pi
International Journal of Infectious Diseases.2022; 118: 34. CrossRef - Epidemiology of liver failure in Asia‐Pacific region
Ankur Jindal, Shiv K. Sarin
Liver International.2022; 42(9): 2093. CrossRef - Hepatitis A in children: evaluation of atypical manifestations
Derya Kalyoncu, Nafiye Urganci, Seda Geylani Gulec
Paediatrica Indonesiana.2020; 60(5): 239. CrossRef - Challenges in Management of Hepatitis A Virus Epidemiological Transition in Mexico
Jorge L. Trujillo-Ochoa, Oliver Viera-Segura, Nora A. Fierro
Annals of Hepatology.2019; 18(1): 14. CrossRef - Update on Clinical and Epidemiological Features of Viral Hepatitis A
Nada Lahmidani
Gastroenterology & Hepatology: Open Access.2016;[Epub] CrossRef - Usefulness of B-mode and doppler sonography for the diagnosis of severe acute viral hepatitis A
Sang Wook Shin, Tae Yeob Kim, Woo Kyoung Jeong, Yongsoo Kim, Jinoo Kim, Young Hwan Kim, Hwan Cheol Park, Joo Hyun Sohn
Journal of Clinical Ultrasound.2015; 43(6): 384. CrossRef - Prognostic Indicators for Acute Liver Failure Development and Mortality in Patients with Hepatitis A: Consecutive Case Analysis
Hye Sun Shin, Sae Pyul Kim, Sang Hoon Han, Do Young Kim, Sang Hoon Ahn, Kwang-Hyub Han, Chae Yoon Chon, Jun Yong Park
Yonsei Medical Journal.2014; 55(4): 953. CrossRef - Genotypic shift of the hepatitis A virus and its clinical impact on acute hepatitis A in Korea: a nationwide multicenter study
Ji Hoon Kim, Jong Eun Yeon, Soon Koo Baik, Young Seok Kim, Hong Soo Kim, Sang Hoon Park, Myung-Seok Lee, Joo Hyun Sohn, Jin-Woo Lee, Sung Kyu Choi, So Young Kwon, Jong Young Choi, Ju Hyun Kim, Soon Young Kang, Hyonggin An, Yeon Seok Seo, Hyung Joon Yim, J
Scandinavian Journal of Infectious Diseases.2013; 45(11): 811. CrossRef - Comparative analysis of disease severity between genotypes IA and IIIA of hepatitis A virus
Young Kyung Yoon, Jong Eun Yeon, Ji Hoon Kim, Hee Sun Sim, Jeong Yeon Kim, Dae Won Park, Jang Wook Sohn, Byung Chul Chun, Min Ja Kim
Journal of Medical Virology.2011; 83(8): 1308. CrossRef
