Prognostic value of serum osteopontin in hepatocellular carcinoma patients treated with transarterial chemoembolization

doi:10.3350/kjhep.2009.15.3.320

Articles

Page Path

Original Article

Prognostic value of serum osteopontin in hepatocellular carcinoma patients treated with transarterial chemoembolization

Sung Hoon Kim, M.D., Young-Hwa Chung, M.D.1, Soo Hyun Yang, M.D., Jeong A Kim, M.S.1, Myoung Kuk Jang, M.D.2, Sung Eun Kim, M.D.1, Danbi Lee, M.D.1, Sae Hwan Lee, M.D.1, Don Lee, M.D.1, Kang Mo Kim, M.D.1, Young Suk Lim, M.D.1, Han Chu Lee, M.D.1, Yung Sang Lee, M.D.1, Dong Jin Suh, M.D.1

Clin Mol Hepatol 2009;15(3):320-330.

DOI: https://doi.org/10.3350/kjhep.2009.15.3.320

Published online: September 30, 2009

Author Affiliations

Department of Internal Medicine, Seoul Veterans Hospital; 1Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center; 2Department of Internal edicine, Hallym University College of Medicine, Kangdong Sacred Heart Hospital, Seoul, Korea.

7,350 Views
46 Download
18 Crossref
21 Scopus

prev next

Full Article

Download PDF

Abstract

Background/Aims
Osteopontin (OPN) is overexpressed in hepatocellular carcinoma (HCC) with postoperative recurrence or extrahepatic metastasis. However, its prognostic value in patients treated with transarterial chemoembolization (TACE) is unclear. We investigated the utility of serum OPN levels and changes therein as prognostic markers in HCC patients who have received TACE. Methods: Forty-six patients with HCC were enrolled. Serum OPN levels were measured before and 4 weeks after TACE. Serum biochemistry and computed tomography (CT) scans were analyzed. We evaluated baseline serum OPN levels and subsequent changes therein in relation to tumor responses and cumulative survival rates following TACE. A decreasing pattern was defined as a decrease after TACE of more than 10% relative to baseline levels. A "responder" was defined as a patient who exhibited a tumor necrosis rate of higher than 50% on the follow-up CT scan. Results: Higher initial serum OPN levels were associated with a large tumor, portal vein invasion, and an advanced tumor stage. Patients who had lower initial serum OPN levels and those who exhibited decreasing patterns after TACE tended to have more favorable tumor responses (P=0.043 and 0.055, respectively) and exhibited better cumulative survival rates (P=0.036 and 0.030, respectively). However, the initial serum OPN level and subsequent changes in serum OPN levels were not independent predictors for survival on multivariate analysis. Conclusions: Serum OPN levels were significantly higher in patients with advanced HCC. In addition, HCC patients with low pretreatment serum OPN levels and those for whom serum OPN declined following TACE exhibited better tumor responses and survived for longer. (Korean J Hepatol 2009,15:320-330)

Keywords: Carcinoma, Hepatocellular; Osteopontin; Transarterial chemoembolization; Prognostic marker

Citations

Citations to this article as recorded by

Novel serum biomarkers for real-time treatment monitoring and prognostication in hepatocellular carcinoma patients
Wang Jing, Yang Qing, Zhao Lei, Feng Yiming
Journal of Medical Biochemistry.2026; (00): 152. CrossRef
A radiomics signature associated with underlying gene expression pattern for the prediction of prognosis and treatment response in hepatocellular carcinoma
Dandan Wang, Linhan Zhang, Zhongqi Sun, Huijie Jiang, Jinfeng Zhang
European Journal of Radiology.2023; 167: 111086. CrossRef
Tumor Biomarkers and Interventional Oncology: Impact on Local Outcomes for Liver and Lung Malignancy
Yuan-Mao Lin, Ryosuke Taiji, Marco Calandri, Bruno C. Odisio
Current Oncology Reports.2021;[Epub] CrossRef
Prognostic Value of Serum Apolipoprotein B to Apolipoprotein A-I Ratio in Hepatocellular Carcinoma Patients Treated with Transcatheter Arterial Chemoembolization: A Propensity Score-Matched Analysis
Meng-Meng Liu, Zhan-Hong Chen, Li-Yun Zhao, Jing-Yuan Zhao, Dai-Lin Rong, Xiao-Kun Ma, Dan-Yun Ruan, Jin-Xiang Lin, Jing-Jing Qi, Pei-Shan Hu, Jing-Yun Wen, Jie Chen, Qu Lin, Xiang-Yuan Wu, Li Wei, Min Dong
Oncology Research and Treatment.2021; 44(9): 450. CrossRef
ARD1/NAA10 in hepatocellular carcinoma: pathways and clinical implications
Danbi Lee, Myoung-Kuk Jang, Ji Hae Seo, Soo Hyung Ryu, Jeong A. Kim, Young-Hwa Chung
Experimental & Molecular Medicine.2018; 50(7): 1. CrossRef
Prognostic value of osteopontin in patients with hepatocellular carcinoma
Tingting Sun, Peng Li, Diwen Sun, Qingao Bu, Guoqiang Li
Medicine.2018; 97(43): e12954. CrossRef
Pilot Evaluation of Angiogenesis Signaling Factor Response after Transcatheter Arterial Embolization for Hepatocellular Carcinoma
James Ronald, Andrew B. Nixon, Daniele Marin, Rajan T. Gupta, Gemini Janas, Willa Chen, Paul V. Suhocki, Waleska Pabon-Ramos, David R. Sopko, Mark D. Starr, John C. Brady, Herbert I. Hurwitz, Charles Y. Kim
Radiology.2017; 285(1): 311. CrossRef
Overexpression of osteopontin promotes resistance to cisplatin treatment in HCC
KUN DING, LU FAN, SHIJUN CHEN, YANNA WANG, HAIFENG YU, YANNI SUN, JIGUANG YU, LI WANG, XIANGZHONG LIU, YOUDE LIU
Oncology Reports.2015; 34(6): 3297. CrossRef
Higher Matrix Stiffness Upregulates Osteopontin Expression in Hepatocellular Carcinoma Cells Mediated by Integrin β1/GSK3β/β-Catenin Signaling Pathway
Yang You, Qiongdan Zheng, Yinying Dong, Yaohui Wang, Lan Zhang, Tongchun Xue, Xiaoying Xie, Chao Hu, Zhiming Wang, Rongxin Chen, Yanhong Wang, Jiefeng Cui, Zhenggang Ren, David Wai Chan
PLOS ONE.2015; 10(8): e0134243. CrossRef
Circulating biomarkers of hepatocellular carcinoma response after locoregional treatments: New insights
Maria Tampaki
World Journal of Hepatology.2015; 7(14): 1834. CrossRef
Meta-Analysis of the Prognostic and Diagnostic Significance of Serum/Plasma Osteopontin in Hepatocellular Carcinoma
JiWen Cheng, WanLi Wang, CaiHong Sun, MuXing Li, Bo Wang, Yi Lv
Journal of Clinical Gastroenterology.2014; 48(9): 806. CrossRef
Circulating markers for prognosis of hepatocellular carcinoma
Kwong-Fai Wong, Zhi Xu, Jinfei Chen, Nikki P Lee, John M Luk
Expert Opinion on Medical Diagnostics.2013; 7(4): 319. CrossRef
Plasma Osteopontin Level as a Diagnostic Marker of Hepatocellular Carcinoma in Patients with Radiological Evidence of Focal Hepatic Lesions
Ashraf Khalil, Jamalat Elgedawy, Mohammed F Faramawi, Ashraf Elfert, Ibrahim Salama, Ahmed Abbass, Hala Elsaid, Hatem Elsebaai
Tumori Journal.2013; 99(1): 100. CrossRef
Recurrence and Poor Prognosis Following Resection of Small Hepatitis B-Related Hepatocellular Carcinoma Lesions Are Associated with Aberrant Tumor Expression Profiles of Glypican 3 and Osteopontin
Ming-Chin Yu, Yun-Shien Lee, Sey-En Lin, Hsiang-Yao Wu, Tse-Ching Chen, Wei-Chen Lee, Miin-Fu Chen, Chi-Neu Tsai
Annals of Surgical Oncology.2012; 19(S3): 455. CrossRef
Prognostic significance of osteopontin in hepatocellular carcinoma: A meta‐analysis
Chuan‐Hai Zhang, Ge‐Liang Xu, Wei‐Dong Jia, Yong‐Sheng Ge, Jian‐Sheng Li, Jin‐Liang Ma, Wei‐Hua Ren
International Journal of Cancer.2012; 130(11): 2685. CrossRef
ATX–LPA Axis Induces Expression of OPN in Hepatic Cancer Cell SMMC7721
Rihua Zhang, Zhihong Zhang, Xiaolin Pan, Xiayue Huang, Zuhu Huang, Guoxin Zhang
The Anatomical Record.2011; 294(3): 406. CrossRef
Osteopontin as a Key Mediator for Vasculogenic Mimicry in Hepatocellular Carcinoma
Wenbin Liu, Geliang Xu, Jinliang Ma, Weidong Jia, Jiansheng Li, Ke Chen, Wei Wang, Chen Hao, Yongcang Wang, Xiujun Wang
The Tohoku Journal of Experimental Medicine.2011; 224(1): 29. CrossRef
Clinical Significance of Plasma Osteopontin Level in Egyptian Patients with Hepatitis C Virus-related Hepatocellular Carcinoma
Sahar Saad El-Din Bessa, Nadia Mohamed Elwan, Ghada Abdul Moemen Suliman, Safinaz Hamdy El-Shourbagy
Archives of Medical Research.2010; 41(7): 541. CrossRef

Cite

CITE

export

Copy Download

Format

Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

Format:

RIS — For EndNote, ProCite, RefWorks, and most other reference management software
BibTeX — For JabRef, BibDesk, and other BibTeX-specific software

Include:

Citation for the content below
Citation and abstract for the content below

Prognostic value of serum osteopontin in hepatocellular carcinoma patients treated with transarterial chemoembolization

Korean J Hepatol. 2009;15(3):320-330. Published online September 30, 2009

DOI: https://doi.org/10.3350/kjhep.2009.15.3.320

Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

Format:

RIS — For EndNote, ProCite, RefWorks, and most other reference management software
bib — For JabRef, BibDesk, and other BibTeX-specific software

Include:

Citation for the content below
Citation and abstract for the content below

Prognostic value of serum osteopontin in hepatocellular carcinoma patients treated with transarterial chemoembolization

Korean J Hepatol. 2009;15(3):320-330. Published online September 30, 2009

DOI: https://doi.org/10.3350/kjhep.2009.15.3.320

Articles

Page Path

Prognostic value of serum osteopontin in hepatocellular carcinoma patients treated with transarterial chemoembolization

Full Article

Abstract

Citations

CITE

Download Citation

Format:

Include:

Related articles

ABOUT

BROWSE ARTICLES

FOR CONTRIBUTORS