Background/Aims Early recurrence (ER) after liver resection is one of the most important factors
impacting the prognosis and survival of patients with hepatocellular carcinoma (HCC). This study aimed to
identify the factors associated with ER after curative hepatic resection for HCC. Methods: From the July 2000
to July 2006, 144 patients underwent hepatic resection for HCC at a single institution. After excluding those
with ruptured HCC, combined or mixed HCC, and who died during admission, 116 patients were analyzed.
Patients with ER (defined as within 1 year) were compared with those who remained free of disease for more
than 1 year. Various clinical characteristics including tumor and operative factors were evaluated to determine
the factors predicting postoperative ER using univariate and multivariate analyses. Results: ER occurred in
51 patients (44%). In the univariate analysis, tumor size (P=0.001), microvascular invasion (P=0.003), portal
vein invasion (P=0.001), TNM stage (P=0.010), serum levels of alpha-fetoprotein (AFP) (P=0.002) and aspartate
aminotransferase (AST) (P=0.011), and operative time (P=0.033) were significantly associated with ER.
AFP and AST were the independent predictors of ER in the multivariate analysis (P<0.05). Conclusions:
Preoperative serum AFP and AST levels were the independent risk factors for ER after surgical resection for
HCC. Close postoperative surveillance is recommended for early detection of recurrence and additional treatments
in patients with these factors. (Korean J Hepatol 2008;14:371-380)
The impact of curative conversion therapy aimed at a cancer‐free state in patients with hepatocellular carcinoma treated with atezolizumab plus bevacizumab Shigeo Shimose, Hideki Iwamoto, Tomotake Shirono, Masatoshi Tanaka, Takashi Niizeki, Masahiko Kajiwara, Satoshi Itano, Yoichi Yano, Satoru Matsugaki, Etsuko Moriyama, Yu Noda, Masahito Nakano, Ryoko Kuromatsu, Hironori Koga, Takumi Kawaguchi Cancer Medicine.2023; 12(11): 12325. CrossRef
Prognostic Analysis of Postoperative Survival for Ruptured Hepatocellular Carcinoma with or without Cirrhosis Feng Xia, Peng Zhu, Xiao-Ping Chen, Bi-Xiang Zhang, Ming-Yu Zhang, Subhadeep Roy Journal of Oncology.2022; 2022: 1. CrossRef
Hepatocellular carcinoma: preoperative gadoxetic acid–enhanced MR imaging can predict early recurrence after curative resection using image features and texture analysis Su Joa Ahn, Jung Hoon Kim, Sang Joon Park, Seung Tack Kim, Joon Koo Han Abdominal Radiology.2019; 44(2): 539. CrossRef
Alpha fetoprotein mediates HBx induced carcinogenesis in the hepatocyte cytoplasm Chao Zhang, Xiangmei Chen, Hui Liu, Hui Li, Wei Jiang, Wenting Hou, Michael A. McNutt, Fengmin Lu, Gang Li International Journal of Cancer.2015; 137(8): 1818. CrossRef
Metabolic profiling study of early and late recurrence of hepatocellular carcinoma based on liquid chromatography-mass spectrometry Lina Zhou, Yuan Liao, Peiyuan Yin, Zhongda Zeng, Jia Li, Xin Lu, Limin Zheng, Guowang Xu Journal of Chromatography B.2014; 966: 163. CrossRef
Comparing Staging Systems for Predicting Prognosis and Survival in Patients with Hepatocellular Carcinoma in Egypt Asmaa Ibrahim Gomaa, Mohamed Saad Hashim, Imam Waked, Ferruccio Bonino PLoS ONE.2014; 9(3): e90929. CrossRef
Early diffuse recurrence of hepatocellular carcinoma after percutaneous radiofrequency ablation: analysis of risk factors Hee Young Lee, Hyunchul Rhim, Min Woo Lee, Young-sun Kim, Dongil Choi, Min Jung Park, Young Kon Kim, Seong Hyun Kim, Hyo Keun Lim European Radiology.2013; 23(1): 190. CrossRef
Diffusion-weighted imaging of hepatocellular carcinoma for predicting early recurrence and survival after hepatectomy Ali Muhi, Tomoaki Ichikawa, Utaroh Motosugi, Katsuhiro Sano, Zareen Fatima, Masanori Matsuda, Hideki Fujii, Nobuyuki Enomoto, Tsutomu Araki Hepatology International.2013; 7(2): 662. CrossRef
Localized Uterine Recurrence of Hepatocellular Carcinoma 4 Years after Curative Resection Sang Jin Lee, Jung Woo Shin, Neung Hwa Park, Yang Won Nah, Hang Jo Yoo, Yoong Ki Jung, Hye Jeong Choi Korean Journal of Medicine.2012; 82(5): 603. CrossRef
Impact of intracellular alpha fetoprotein on retinoic acid receptors‐mediated expression of GADD153 in human hepatoma cell lines Chaoying Li, Shanshan Wang, Wei Jiang, Hui Li, Zhongmin Liu, Chao Zhang, Michael A. McNutt, Gang Li International Journal of Cancer.2012; 130(4): 754. CrossRef
The Survival Benefit of Liver Transplantation for Hepatocellular Carcinoma Patients with Hepatitis B Virus Infection and Cirrhosis Qing Zhang, Xinguo Chen, Yunjin Zang, Li Zhang, Hong Chen, Letian Wang, Yujian Niu, Xiuyun Ren, Zhongyang Shen, Lei Shang, Michael Bouchard PLoS ONE.2012; 7(12): e50919. CrossRef
Risk Factors for Intrahepatic Recurrence after Resection of Hepatocellular Carcinomas in Patients with Hepatitis B Virus Infection Myung Hee Yoon, Young Il Choi, Kwang Kuk Park, Dong Hoon Shin, Chung Han Lee Korean Journal of Hepato-Biliary-Pancreatic Surgery.2011; 15(2): 83. CrossRef
