Alfuzosin-induced Acute Liver Injury

doi:2007.13.3.414

Korean J Hepatol > Volume 13(3); 2007 > Article

The Korean Journal of Hepatology 2007;13(3): 414-418.
doi: https://doi.org/10.3350/kjhep.2007.13.3.414

Alfuzosin-induced Acute Liver Injury

Seok Yeon Kim, M.D., Byung-Ho Kim, M.D., Seok Ho Dong, M.D., Hyo Jong Kim, M.D., Young Woon Chang, M.D., Rin Chang, M.D., Yoon Wha Kim, M.D.1

Departments of Internal Medicine and Pathology1, Kyung Hee University School of Medicine, Seoul, Korea

ABSTRACT

We describe a 56-year-old man who developed an acute liver injury after taking alfuzosin for 1 month to control his newly diagnosed benign prostatic hypertrophy (BPH). There was no history of alcohol consumption or the taking herbal or traditional remedies. Viral causes, autoimmune hepatitis, and biliary tree obstruction were excluded. Other rare causes of hepatitis such as hemochromatosis, primary biliary cirrhosis and Wilson’s disease were also absent in this patient. His liver test results began to improve after discontinuing the alfuzosin. Two weeks later, alfuzosin was administered again because the patient complained of dysuria. After 10 days of alfuzosin reuse, his liver test results worsened. Five months later after the complete discontinuation of the drug, his liver test results had returned to normal. This clinical sequence suggests that alfuzosin caused his acute liver injury. (Korean J Hepatol 2007;13:414-418)

KeyWords: Alfuzosin; Hepatitis, toxic; Benign prostatic hyperplasia