Korean J Hepatol > Volume 13(2); 2007 > Article
The Korean Journal of Hepatology 2007;13(2): 196-207.
Evaluation of Predictive Value of Okuda, TNM, CLIP and JIS Staging Systems for Hepatocellular Carcinoma Patients
Sung-Wook Lee, M.D., Sang-Young Han, M.D., Kyoung-Tae Kim, M.D., Yang-Hyun Baek, M.D., In Young Koh, M.D., Byoung-Hee Kim, M.D., Eun-Hee Park, M.D., Jin-Seok Jang, M.D., Myung-Hwan Roh, M.D, Jong Cheol Choi, M.D.
Department of Internal Medicine and Diagnostic Radiology1, Dong-A University College of Medicine, Busan, Korea
The aims of this study were to validate the prognostic value of the JIS score for HCC and to compare discriminatory ability and predictive power with other staging systems such as Okuda, TNM and CLIP. Methods: We analyzed the clinical records of 210 patients who were diagnosed as HCC from 2000 to 2002. Univariate and multivariate survival analyses were done to find out factors to affect survival. To validate prognostic value of those staging systems, survival curve was obtained and analyzed by the Kaplan-Meier’s method, and to compare discriminatory ability and predictive power, Homogeneity LR X2 test and AIC score were used. Results: The median survival was 19.5 months (19.1±14.9). The number of patients and 3-year survival rate for those staging systems were Okuda 1(126, 57.7%), 2(63, 9.0%) and 3(21, 0.0%) (p<0.001); TNM I (34, 63.1%), II (71, 59.4%), III (50, 22.4%), IV-A (6, 14.3%) and IV-B (1, 6.5%) (p<0.001); CLIP 0 (79, 68.5%), 1 (39, 34.2%), 2 (36, 16.7%), 3 (25, 20.0%), 4 (18, 5.1%), 5 (9, 11.1%) and 6 (4, 0.0%) (p<0.001) and JIS 0 (26, 78.9%), 1 (65, 65.3%), 2 (43, 21.9%), 3 (40, 25, 8.0%) and 5 (11, 2.0%)(p<0.001) in univariate analysis using Kaplan-Meier analysis. Homogeneity LR X2 test showed more stratification power in JIS (Okuda, 102.8; TNM, 128.2; CLIP, 148.4 and JIS, 185.6) and AIC score showed superior predictive power in JIS system (Okuda, 1228.5; TNM, 1130.3; CLIP, 1117.1 and JIS, 1093.6). Conclusions: The proposed JIS system is useful system to predict survival of HCC patients. The discriminate ability of the JIS score is much better than other staging systems and has better prognostic predictive power compared to other staging systems. (Korean J Hepatol 2007;13:196-207)
KeyWords: Carcinoma, hepatocellular; Neoplasm staging; Outcome assessment, patient; Prognosis; Survival analysis

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