Korean J Hepatol > Volume 11(2); 2005 > Article
The Korean Journal of Hepatology 2005;11(2): 164-168.
Spontaneous Resolution of Vanishing Bile Duct Syndrome in Hodgkin`s Lymphoma
Woo Sik Han , Eun Suk Jung , Youn Ho Kim , Chung Ho Kim , Sung Chul Park , Ji Yeon Lee , Yun Jung Chang , Jong Eun Yeon , Kwan Soo Byun , Chang Hong Lee
Department of Hepatology, Korea University College of Medicine, Seoul, Korea
Abstract
Cholestasis in a patient with Hodgkin’s disease is uncommon, and the causes of cholestasis are mainly direct tumor involvement of the liver, hepatotoxic effects of drugs, viral hepatitis, sepsis and opportunistic infections. Vanishing bile duct syndrome (VBDS) represents a very rare cause for cholestasis in this disease. We report here on a case of a 45-year-old man who developed VBDS during the complete remission stage of Hodgkin’s lymphoma. There was no history of hepatitis or intravenous drug abuse, and the patient had negative results for hepatitis A virus, hepatitis B virus, hepatitis C virus, cytomegalovirus, and human immunodeficiency virus. The serological studies for antinuclear antibodies, anti-mitochondrial antibodies and anti-smooth muscle antibodies were also negative. Liver biopsy disclosed the absence of interlobular bile ducts in 9 of 10 portal tracts without any active lymphocyte infiltration and there were no Reed-Sternberg cell in the liver. The patient’s cholestasis was in remission and the serum bililrubin level was normalized after two months without treatment, but tumor recurrence was noted at multiple sites of the abdominal lymph nodes on follow-up abdomino-pelvic computed tomogram. (Korean J Hepatol 2005;11:164-168)
KeyWords: Vanishing bile duct syndrome, Hodgkin’s lymphoma
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