Two Cases of Autoimmnune Hepatitis Associated with Systemic Lupus Erythematosus

Korean J Hepatol > Volume 9(3); 2003 > Article

The Korean Journal of Hepatology 2003;9(3): 231-235.

Two Cases of Autoimmnune Hepatitis Associated with Systemic Lupus Erythematosus

Yun Jang Ug , Park Sang Hun , Kim Eun Jeong , Hong Ji Hyeon , Lee Hyeong Seog , O Gil Chan , Park Cheol Hui , Han Tae Ho , Lee Dong Geun , Kim Jong Hyeog , Park Hye Lim

Department of Internal Medicine and Pathology1, Hallym University, College of Medicine, Anyang, Korea

ABSTRACT

Autoimmune hepatitis (AIH) is a chronic necroinflammatory liver disease of unknown cause associated with circulating autoantibodies and high serum globulin level. Systemic lupus erythematosus (SLE) is a disease of unknown etiology in which tissues and cells are damaged by pathogenic autoantibodies and immune complex, of SLE and autoimmune hepatitis has not been clearly defined in the past due to similarities in clinical and biochemical features. A scoring system for the diagnosis of AIH has been established, and AIH and SLE-associated hepatitis have been defined as two different entities, although both have the same autoimmune features such as polyarthralgia, hypergammaglobulinemia and circulating autoantibodies. AIH has been considered to occur infrequently in SLE. We report two cases of AIH which simultaneously satisfied the criteria of SLE.(Korean J Hepatol 2003;9:231-235)

KeyWords: Hepatitis/Autoimmune, Lupus erythematosus/Systemic