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Korean J Hepatol > Volume 9(3); 2003 > Article
The Korean Journal of Hepatology 2003;9(3): 212-221.
Assessment of Quality of Life and Associated Factors in Patients with Chronic Viral Liver Disease
Chang Keun Park, M.D., Soo Young Park, M.D., Eun Soo Kim, M.D., Jin Hyung Park, M.D., Dong Woo Hyun, M.D., Young Mi Yun, M.D., Chang Min Jo, M.D., Won Young Tak, M.D., Young Oh Kweon, M.D., Sung Kook Kim, M.D., Yong Hwan Choi, M.D. and Shin Goo Park, M.D.1
Department of Internal Medicine, Occupational & Environmental Medicine1 Kyungpook National University College of Medicine, Daegu, Korea
Abstract

Background/Aims:
The aim of this study was to measure health related quality of life (HRQOL) in patients with chronic viral hepatitis or cirrhosis and to determine factors associated with more severe impairment.
Methods:
We conducted a cross-sectional study in which we documented patients` demographic and clinical characteristics and measured their HRQOL using the Korean version of Short form-36. A total of 375 patients were enrolled in the study. We compared patients` HRQOL with that of 750 participants in a control group and assessed the association of HRQOL impairment with clinical parameters.
Results:
In all except two domains (physical functioning, bodily pain) of SF-36, HRQOL scores were significantly lower in the patient group than in the control group (p<0.001). The difference was more prominent in those domains reflective of mental, rather than physical, health. When patient group was classified as noncirrhosis, child A, B, or C according to modified Child-Pugh classification, severe liver disease was associated with a lower HRQOL score. Interestingly, scores of domains reflective of mental health were decreased from the early stage of disease (noncirrhosis or Child-Pugh A). Those of domains reflective of physical health, however, were decreased only in advanced stages of disease (Child-Pugh B or C). There are weak but significant correlations between SF-36 scores and age, serum albumin, serum bilirubin, and prothrombin time, but no correlation with histologic activity, transaminase level, disease duration, virus type (HBV or HCV) and HBV DNA level.
Conclusions:
Compared with the control group, patients with chronic viral hepatitis or cirrhosis showed substantial impairment of HRQOL, which is further affected by worsening disease severity. More concern about HRQOL should be warranted in the evaluation of health change due to disease progression or therapeutic trial.(Korean J Hepatol 2003;9:212-221)
KeyWords: Health-Related Quality of Life (HRQOL), Hepatitis/Viral, Cirrhosis, SF-36
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