Korean J Hepatol > Volume 9(1); 2003 > Article
The Korean Journal of Hepatology 2003;9(1): 25-30.
A Case of Auto-immune Hepatitis Associated with Primary Sjogren`s Syndrome
Yong Dae Kwon , Hong Sik Lee , Chul Hee Park , Yoon Tae Jeen , Hoon Jai Chun , Sang Woo Lee , Jai Hyun Choi , Chang Duck Kim , Ho Sang Ryu , Jin Hai Hyun
Department of Internal Medicine, Institute of Digestive Disease and Nutrition, Korea University College of Medicine, Seoul, Korea
ABSTRACT
Auto-immune hepatitis is a chronic necroinflammatory liver disorder that is characterized by hypergammaglobulinemia, auto-antibodies in serum, and, on histological examination, the presence of periportal hepatitis. Although it can be associated with a number of other auto-immune diseases, Sj?gren’s syndrome is rarely associated with auto-immune hepatitis. We herein report an unusual case of auto-immune hepatitis associated with primary Sj?gren’s syndrome. A 39-year-old woman was admitted to our hospital due to jaundice. Laboratory data showed negative viral hepatitis marker, increased serum IgG level, positive anti- nuclear antibody, and an increased rheumatoid factor titer. The patient had no history of taking medications and alcohol. Based on characteristic clinical features, liver biopsy findings, positive Schirmer’s test, and salivary scintigraph, she was diagnosed as having auto-immune hepatitis and Sj?gren’s syndrome. The patient achieved complete remission with steroid monotherapy.(Korean J Hepatol 2003;9:25-30)
KeyWords: Hepatitis/Autoimmune, Sjogren’s syndrome

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