| 원저 : 간세포암의 조직학적 분화도 및 임상적 특징에 따른 E - cadherin 과 β - catenin 의 발현 양상 ( Original Articles : Expression Patterns of E - cadherin and β - catenin According to Clinicopathological Characteristics of Hepatocellular Carcinoma ) |
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| Expression Patterns of E - cadherin and β - catenin According to Clinicopathological Characteristics of Hepatocellular Carcinoma |
| Si Hyun Bae, M.D.1,4, Eun Sun Jung, M.D.2, Young Min Park, M.D.1,4, Jeong Won Jang, M.D.1,4,
Jong Young Choi, M.D.1,4, Se Hyun Cho, M.D.1,4, Seung Kew Yoon, M.D.1,4, Byung Min Ahn, M.D.1,4,
Sang Bok Cha, M.D.1,4, Kyu Won Chung, M.D.1,4, Hee Sik Sun, M.D.1,4, Doo Ho Park, M.D.1,4,
Byung Kee Kim, M.D.2, Dong Goo Kim, M.D.3 |
| Department of Internal Medicine1, Pathology2 and General Surgery3,
College of Medicine, and WHO Collaborating Center for Reference and Research on Viral Hepatitis4,
The Catholic University of Korea, Seoul, Korea |
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| ABSTRACT |
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Background/Aims
E-cadherin is involved in intercellular binding and cellular polarity formation. β-catenin plays a fundamental role in regulation of the E-cadherin cell adhesion complex. The abnormalities of the components of the complex may disrupt this adhesive function. We investigated the expression patterns of E-cadherin and β-catenin to determine the clinical significance of these proteins in hepatocellular carcinoma. Materials/Methods: Thirty-six hepaticellular carcinoma tissues and adjacent non-tumor specimens were analyzed. Subcellular distribution of E-cadherin and β-catenin was examined by immunohistochemistry staining. We evaluated the patterns of the expression, and investigated the relationship with the cause of HCC; level of AFP; TNM stage; tumor size; growth types; metastasis; differentiation grade of HCC; and presence of portal vein thrombosis. Results: Immunohistochemistry showed that all non-tumor tissues had membranous type staining of E-cadherin. All non-tumor tissues showed cytoplasmic type staining of β-catenin, but no β -catenin accumulation in nuclei was found. 58% (21/36) of HCC showed positive expression of E-cadherin in cytoplasmic membrane. The cytoplasmic expression of β-catenin in HCC was 83% (30/36); nuclear expression in 14% (5/36); and no staining in 3% (1/36). Nuclear β-catenin expression was observed in none (0/4) of the well-differentiated HCC; 17%(3/9) of moderate-differentiated HCC; and 17%(2/6) of poorly-differentiated HCC. There were no relationships between E-cadherin and β-catenin expression with other clinicopathologic factors. Conclusions: Loss of cytoplasmic staining of E-cadherin and nuclear accumulation of β-catenin were observed in HCC. Nuclear accumulation of β-catenin was not found in well differentiated HCC but was found in poorly differentiated HCC. (Korean J Hepatol 2002;8:297-303) |
| KeyWords:
Neoplasm/Liver/Hepatocellular carcinoma, E-cadherin, β-catenin, Immunohistochemistry |
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