Korean J Hepatol > Volume 8(1); 2002 > Article
The Korean Journal of Hepatology 2002;8(1): 71-79.
원저 : 간문맥 혈전이 동반된 진행성 간세포암에서의 동시 항암 화학 - 방사선요법 ( Original Articles : Concurrent Chemo - Radiation Therapy for Advanced Hepatocellular Carcinoma with Portal Vein Thrombosis )
Concurrent Chemo - Radiation Therapy for Advanced Hepatocellular Carcinoma with Portal Vein Thrombosis
Jin Suk Kim, M.D., Kwang-Hyub Han, M.D., Do Yun Lee, M.D.* , Jin-Sil Seong, M.D.† , Young Hoon Youn, M.D., Jae Youn Cheong, M.D., Sang Hoon Ahn, M.D., Chae Yoon Chon, M.D., and Young Myoung Moon, M.D.
Departments of Internal Medicine, Diagnostic Radiology *, and Radiation Oncology †, Yonsei University College of Medicine, Seoul, Korea
Abstract

Background/Aims:
Advanced hepatocellular carcinoma with portal vein thrombosis has a poor prognosis. This study was undertaken to evaluate the therapeutic effects of concurrent chemo-radiation therapy in advanced hepatocellular carcinoma with portal vein thrombosis.
Methods:
A total of 54 patients with advanced hepatocellular carcinoma (TNM stage IVa) were enrolled. Nineteen patients were treated with external beam radiotherapy (4,500 cGy/ 5 weeks) and intrahepatic arterial 5-FU infusion (500 mg on 1-5 day and 30-35 day, respectively) via implanted chemoport. The others were treated with intrahepatic arterial cisplatin infusion (80 mg/m2).
Results:
In patients treated with concurrent chemo-radiation therapy, response rates at 2nd and 6th months were 42.1% and 26.3%, respectively. In patients treated with intrahepatic arterial cisplatin therapy, response rates at 2nd and 6th months were 2.9% and 0%, respectively. The median survival time was 11.6 months in concurrent chemo-radiation therapy and 4.8 months in intrahepatic arterial cisplatin infusion therapy. Concurrent chemo-radiation therapy produced better response rates and longer survival time than those of intrahepatic arterial cisplatin infusion therapy (p<0.05).
Conclusions:
Concurrent chemo-radiation therapy achieved favorable results in advanced hepatocellular carcinoma with portal vein thrombosis and can be considered as a treatment option for the management of advanced hepatocellular carcinoma.(Korean J Hepatol 2002;8:71-79)
KeyWords: Neoplasm/ Liver/Hepatocellular carcinoma, Portal vein thrombosis , Chemo- radiation therapy Cisplatin

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