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Korean J Hepatol > Volume 7(4); 2001 > Article
The Korean Journal of Hepatology 2001;7(4): 459-466.
원저 : 간세포암종 환자의 종양 조직 내 P-glycoprotein 및 p53 단백의 발현이 항암화학요법의 반응률에 미치는 영향 ( Original Articles : Expression of P-glycoprotein and p53 Protein in Stage 4 Hepatocellular Carcinoma Treated with Systemic Chemotherapy )
Expression of P-glycoprotein and p53 Protein in Stage 4 Hepatocellular Carcinoma Treated with Systemic Chemotherapy
Sang Hyung Cho, Hyun Ho Cho, Young Ho Kim, Jinmo Chung, Daehyun Choi, Kwanghee Cho, Jin Hyuk Lee, Sook-Hyang Jeong, Chul Ju Han, You Cheoul Kim, Jhin Oh Lee, Jin Haeng Chung*, and Seung-Sook Lee*
Department of Internal Medicine & Anatomical Pathology*, Korea Cancer Center Hospital, Seoul, Korea
Abstract
Background / Aims : Hepatocellular carcinoma(HCC) is a drug -resistant tumor. The expression of a multidrug resistant gene, P-glycoprotein(P-gp) is a major mechanism of drug resistance. The aims of our study were, firstly, to observe the expression rate of P-gp in HCC tissue obtained by percutaneous fine needle aspiration(PCNA) from stage IV HCC patients; secondly to examine the association between P-gp and chemotherapeutic response ; and finally to investigate the correlation between p53 protein expression and P-gp expression. Subjects and
Method
: We studied 29 cases of stage IV HCC treated by systemic chemotherapy. Expression of P-gp and p53 were evaluated by immunohistochmical staining of HCC tissue with human monoclonal anti body, JSB-1(Anti P-gp ) and DO-7(Anti p53), respectively. We analyzes the results of immunohistochmical staining of HCC tissues of the patients in relation to chemotherapeutic response and other clinical charateristics. Results : The expression rate of P-gp was 27.5%. Partial response to anti-cancar chemotherapy was observed in 16.7% of the to chemotherapeutic response, none of the response to anti-caner chemotherapy was observed in 16.7% of the patients. Although we could not see a statisrically significant association between to chemotherapeutic response expression and chemotherapeutic response , none of the response patients showed chemotherapeutic response P-gp expression. p 53 protein expression was found in 45% of the patients. There was no significant correlation between p 53 protein expression and P-gp expression.
Conclusions
: Although the number of our study subjects was small, chemotherapy- responsive patients didn`t show P-gp expression. P-gp expression might be used as a predictor of response to potentially toxic anti-cancer chemotherapy in HCC patients. Futher study is warranted to confirm our results. (Korean J Hepatol 2001;7 :459 - 466)
KeyWords: Chemotherapy, Neoplasplasm/Liver/Hepatocellular carcinoma, P- glycoprotein, p53 protein
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