Korean J Hepatol > Volume 7(4); 2001 > Article
The Korean Journal of Hepatology 2001;7(4): 401-412.
원저 : 만성 B 형 간염에서 HBsAg 및 HBcAg 의 간세포 내 발현양상과 병리조직학적 소견과의 상관관계 ( Original Articles : The Correlation Between The Histologic Activity and Fibrosis and The Distribution of Intrahepatic HBsAg and HBcAg in Patients With Chroni
The Correlation Between The Histologic Activity and Fibrosis and The Distribution of Intrahepatic HBsAg and HBcAg in Patients With Chronic Hepatitis B
Kwang Bum Cho, M.D., Jung Ho Sohn, M.D., Kyung Sik Park, M.D., Du Young Kwon, M.D., Jae Seok Hwang, M.D., Jung Wook Hur, M.D., Sung Hoon Ahn, M.D., Soong Kuk Park, M.D., and Sang Pyo Kim, M.D.*
Departments of Internal Medicine and Pathology*, Keimyung University School of Medicine, Taegu, Korea
ABSTRACT
Background
/ Aims : The purpose of this study was to assess the correlation between histologic activity and fibrosis and the distribution of intrahepatic hepatitis B core antigen(HBcAg) and surface antigen(HBcAg ) inpatients with chronic hepatitis B . Methods : 141 patients(M:F=141:27) with biopsy-proven chronic hepatitis B ,abnormal liver function, and a positive HBV viral marker(serum HBeAg , serum HBV DNA) were enrolled. Results : HBcAg was expressed in 96 of 141 patoents(68.1%), n HBcAg in 23(16.3%), c HBcAg in 58(41.25), and n-c HBcAg in 15(10.6%). In the cases of HBsAg, 114 of 141 patients(80.9%) were expressed as c HBsAg, 2(1.4%) as m HBsAg, and 16(11,3%) as m-c HBsAg. The presence of intrahepatic HBcAg and HBsAg according to gudat`s calssification was not correlated with activity and fibrosis. But the groups with nuckear expression of HBcAg revealed less inflammatory activity (grade, p=0.003), and less fibrotic stage(p=0.002) than with cytoplasmic or no expression of HBcAg. HBsAg was not. Conclusion : These observations suggest that inflammatory activity and fibrosis of chronic hepatitis B are related to the presence of HBcAg in hepatocytes and the expression of HBcAg. This is a very important finding in hepatocytolysis. (Korean J Hepatol 2001;7 :401- 412)
KeyWords: Immunohistochemistry, Hepatitis / Viral / HBV, HBcAg, HBsAg, Stage, Histological grade

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