1Department of Liver Diseases, The Research Center for Hepatitis and Immunology, National Institute of Global Health and Medicine, Japan Institute for Health Security, Chiba, Japan 2Université Lyon 1, Hospices Civils de Lyon, Inserm, PaThLiv, UMR1350, Lyon, France 3The Lyon Hepatology Institute, IHU EVEREST, Lyon France 4Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital; Hepatitis Research Center, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan