Korean J Hepatol > Volume 6(1); 2000 > Article
The Korean Journal of Hepatology 2000;6(1): 111-123.
원저 : 경간동맥화학색전술을 시행한 간세포암 환자에서 재발인자 및 예후 분석 ( Analysis of Recurrence and Prognostic Factors after Transarterial Chemoembolization in Patients with Hepatocellular Carcinoma )
Analysis of Recurrence and Prognostic Factors after Transarterial Chemoembolization in Patients with Hepatocellular Carcinoma
Min Su Geum, M.D.*, Dae Hyun Kim, M.D., Won Young Tak, M.D. Young Oh Kweon, M.D., Sung Kook Kim, M.D., Yong Hwan Choi, M.D. and Joon Mo Chung, M.D.
Department of Internal Medicine, Andong General Hospital Andong*, Korea Department of Internal Medicine, College of Medicine, Kyungpook National University Taegu, Korea
ABSTRACT
Background/Aims
: Hepatocellular carcinoma (HCC) is a malignant tumor with very poor prognosis if left untreated after diagnosis. However, recent advances in digital subtraction imaging techniques and superselective catheterization seem to have somewhat increased the survival rate in patients with HCC after transarterial chemoembolization (TACE). This study analyzed the relationship between prognostic factors and recurrence after TACE, an aspect which has not attracted much attention. Methods : This investigation included 258 cases of HCC with 100% lipiodol uptake who received TACE for a duration of 13 years from 1985 to 1997. Clinical characteristics, biochemical factors, tumoral factors, angiographic characteristics, embolization technique, degree of lipiodol uptake, response, and recurrence factors were analyzed retrospectively. Results : Significant differences in survival were noted among 3 groups according to cancer-free interval (p<0.01). The different factors between early recurrence group (within 6 months) and late recurrence group (after 18 months) were initial tumor size (8.8±4.1/6.1±3.7cm, p<0.01), tumor type (multinodular,massive/single nodule, p<0.01), ill-defined margin (51.4/22.0%, p<0.01), response after TACE (NC/CR,PR, p<0.01), ALP level (196.1±124.5/144.4±72.0 IU/L, p<0.05), absence of encapsulation (42.3/25.0%, p<0.05), portal vein thrombosis (64.3/14.3%, p<0.05), nonsegmental embolization (46.6/25.0%, p<0.05), post-TACE AFP level (180.5±252.1/76.6±329.8 ng/mL, p<0.05), and recurrence pattern (revascularization of initial lesion/single nodule, p<0.05). Conclusions : Recurrence factors were significant in the survival of patients with HCC after TACE. Therefore, an understanding of the relationship between prognostic factors and recurrence is very important for early detection of recurrence and the timely provision of further TACE treatment. (Korean J Hepatol 2000;6:111-123)
KeyWords: Neoplasm/Liver/Hepatocellular carcinoma, Transarterial chemoembolization, Recurrence

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