Korean J Hepatol > Volume 6(1); 2000 > Article
The Korean Journal of Hepatology 2000;6(1): 82-90.
원저 : 만성신부전 환자에서의 G형 간염 바이러스의 유병률에 관한 연구 ( Prevalence of Hepatitis G Virus Infection in Patients with Chronic Renal Failure )
Prevalence of Hepatitis G Virus Infection in Patients with Chronic Renal Failure
Woo-Won Shin, M.D., Kyung-Ha Song, M.D., Jeong-Hwan Cho, M.D., Hyun-Sook Ahn*, Sung-Wook Lee, M.D., Dong-Joo Keum, M.D., Sung-Jin Bae, M.D.†, Sun-Taec Kim, M.D.†, Kwang-Yul Chang, M.D., Jung-Ha Park, M.D., Myung-Hwan Noh, M.D., Seong-Eun Kim, M.D., Sang-Young Han, M.D., Seok-Reyol Choi, M.D., and Ki-Hyun Kim, M.D.
Dept. of internal medicine, Dong-A University College of Medicine, Institute of Medical Science*, Ginkgo Hospital†, Pusan, Korea
Abstract
Backgrounds/Aims : To investigate the prevalence and clinical implications of hepatitis G virus (HGV) infection in patients with chronic renal failure, a cross-sectional study of 131 hemodialysis patients and 33 kidney transplantation recipients was conducted.
Method
: HGV RNA was amplified by reverse-transcription (RT) polymerase chain reaction (PCR) assay with primers from the 5'-untranslated region of the viral genome.
Results
: The prevalence of HGV infection in patients with chronic renal failure was 25%(41/164). The following factors were taken into consideration: the mean age(43.15±11.97 years vs 46.46±13.08 years), the male to female ratio(2.15:1 vs 1.86:1), the mean of the dialysis duration(4.58±3.18 years vs 3.90±3.31 years), transfusion history (75.6% vs 62.6%), the mean of the ALT level during the prior 6 months(25.78±21.50 IU/L vs 23.00±59.49 IU/L), and the amount of transfusion(6.22±8.03 units vs 5.74±9.44 units). The anti-HCV(4.88% vs 8.94%) showed no difference between HGV RNA positive and negative group. The HBsAg positive ratio was 19.5% and 5.81% in HGV RNA positive group and negative group, respectively.
Conclusion
: The prevalence of HGV infection in patients with chronic renal failure was 25%. There was a higher rate of HBsAg positivity in the HGV RNA positive group rather than in the negative group. HGV infection did not seem to be associated with clinically significant hepatitis.(Korean J Hepatol 2000;6:82-90)
KeyWords: Hepatitis/Viral, Epidemialogy, HGV RNA, Chronic renal failure, Hemodialysis, Kidney transplantation recipients

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