Clin Mol Hepatol > Epub ahead of print
Preventive strategy for nonalcoholic fatty liver disease-related hepatocellular carcinoma
Yuri Cho, Bo Hyun Kim, Joong-Won Park
Center for Liver and Pancreatobiliary Cancer, National Cancer Center, Goyang, Korea
Correspondence :  Joong-Won Park ,
Tel: +82-31-920-1605, Fax: +82-31-920-2799, Email:
Received: August 13, 2022  Revised: September 1, 2022   Accepted: September 5, 2022
The incidence of hepatocellular carcinoma (HCC) associated with nonalcoholic fatty liver disease (NAFLD) has been increasing worldwide, including Asia. Most patients with NAFLD-related HCC are at a much-advanced stage and older age at the time of diagnosis than those with virus-related HCC because they have not undergone HCC surveillance. This review provides an overview of the mechanism of hepatocarcinogenesis in NAFLD, preventive strategies for NAFLDrelated HCC, and strategies for the surveillance of patients with NAFLD.
KeyWords: Hepatocellular carcinoma; Nonalcoholic fatty liver disease; Surveillance; Prevention

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