| 거대효소화(macroenzyme formation)로 인한 단독 Aspartate aminotransferase 상승 ( An Isolated AST Elevation due to Macroenzyme Formation ) |
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| An Isolated AST Elevation due to Macroenzyme Formation |
| Hyeok Kim, M.D., Choon Sik Choi, M.D., Joo Hyun Sohn, M.D.,
Young Woo Sohn, M.D., Dong Soo Han, M.D., Yong Cheol Jeon, M.D.,
Ho Soon Choi, M.D., Joon Soo Hahm, M.D., Min Ho Lee, M.D.,
Kyung Nam Park, M.D., Choon Suhk Kee, M.D. and Duck An Kim, M.D.* |
| Department of Internal Medicine and Ins titute for Digestive Disease Research
Clinical Pathology*, Hanyang University College of Medicine, Kuri-Hospital, Korea |
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| ABSTRACT |
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Serum aspartate aminotransferase (AST) is a common enzyme for the evaluation of the hepatic, muscular and cardiac diseases and is produced also at kidney, brain, pancreas, lung, leukocytes, erythrocytes, etc. The elevation of its activity is usually caused by the necrosis of hepatocytes when there are not muscular injuries or myopathies. Recently, it is found that AST can exist as a macroenzyme by forming a complex with an immunoglobulin and this complex is erroneously considered to indicate the presence of liver disease as a result of elevation of AST activity on routine blood chemistry analysis. We experienced the patient with isolated AST elevation due to the formation of AST-immunoglobulin complex confirmed by AST isoenzyme electrophoresis (EP). (Korean J Hepatol 1999;5:50－54) |
| KeyWords:
Aspartate aminotransferase (AST), Macroenzyme |
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