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Clin Mol Hepatol > Epub ahead of print
Serum Wisteria floribunda agglutinin-positive human Mac-2 binding protein level predicts recurrence of hepatitis B virus-related hepatocellular carcinoma after curative resection
Hye Soo Kim1, Seung Up Kim1,2, Beom Kyung Kim1,2, Jun Yong Park1,2, Do Young Kim1,2, Sang Hoon Ahn1,2, Kwang-Hyub Han1,2, Young Nyun Park3, Dai Hoon Han4, Kyung Sik Kim4, Jin Sub Choi4, Gi Hong Choi4 , Hyon-Suk Kim5
1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
2Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
3Department of Pathology, Yonsei University College of Medicine, Seoul, Korea
4Department of Surgery, Yonsei University College of Medicine, Seoul, Korea
5Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea
Correspondence :  Gi Hong Choi ,
Tel: +82-2-2228-2099, Fax: +82-2-313-8289, Email: choigh@yuhs.ac
Hyon-Suk Kim ,
Tel: +82-2-2228-2443, Fax: +82-2-313-0956, Email: kimhs54@yuhs.ac
Received: August 22, 2018  Revised: November 17, 2018   Accepted: April 10, 2019

To investigate whether serum Wisteria floribunda agglutinin-positive human Mac-2-binding protein (WFA+-M2BP) can predict the recurrence of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) after curative resection.
Patients with chronic hepatitis B (CHB) who underwent curative resection for HCC between 2004 and 2015 were eligible for the study. Recurrence was sub-classified as early (<2 years) or late (≥2 years).
A total of 170 patients with CHB were selected. During the follow-up period (median 22.6 months), 64 (37.6%) patients developed recurrence. In multivariate analyses, WFA+-M2BP level was an independent predictor of overall (hazard ratio [HR]=1.490), early (HR=1.667), and late recurrence (HR=1.416), together with male sex, des-gamma carboxyprothrombin level, maximal tumor size, portal vein invasion, and satellite nodules (all P<0.05). However, WFA+- M2BP level was not predictive of grade B-C posthepatectomy liver failure. The cutoff value that maximized the sum of sensitivity (30.2%) and specificity (90.6%) was 2.14 (area under receiver operating characteristic curve=0.632, P=0.010). Patients with a WFA+-M2BP level >2.14 experienced recurrence more frequently than those with a WFA+-M2BP level ≤2.14 (P=0.011 by log-rank test), and had poorer postoperative outcomes than those with a WFA+-M2BP level ≤2.14 in terms of overall recurrence (56.0 vs. 34.5%, P=0.047) and early recurrence (52.0 vs. 20.7%, P=0.001).
WFA+-M2BP level is an independent predictive factor of HBV-related HCC recurrence after curative resection. Further studies should investigate incorporation of WFA+-M2BP level into tailored postoperative surveillance strategies for patients with CHB.
KeyWords: Hepatitis B; Liver fibrosis; Biomarkers; Hepatocellular carcinoma; Prognosis
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