Korean J Hepatol > Volume 4(1); 1998 > Article
The Korean Journal of Hepatology 1998;4(1): 12-22.
원저 : 만성 B형 활동성 간염 치료에서 합성 인터페론의 용량에 따른 부작용과 단기효과의 비교 ( Original Articles : The Comparison of Adverse Effect and Short - term Effect of Different Dosage of Recombinant Interferon Alpha - 2b Treatment in Patients with Ch
The Comparison of Adverse Effect and Short - term Effect of Different Dosage of Recombinant Interferon Alpha - 2b Treatment in Patients with Chronic Active Hepatitis Type B
Seok Hyun Kim , Jae Kyu Sung , Sang Ou Lee , Kyung Tae Lee , Seung Min Lee , Byung Seok Lee , Jin Hee Kim , Nam Jae Kim , Heon Young Lee
Abstract

Background/Aim
s : The efficacy and adverse effects of two different dosages of recombinant a2b interferon were studied in 45 patients with chronic active hepatitis B from March 1991 to December 1996.
Method
: The 19 patients received in a dose of 3MU thrice weekly for 16 weeks, the 14 patients received in a dose of 5MU thrice weeldy for 16 weeks and the 12 patients received conservative management. We evaluated serologic examination and adverse effects.
Results
1) The rate of improvement in aminotransferase was significantly higher in interferon treated group (75.0%) compared to control group (16.7%) and it tended to be higher in 5MU group (85.6%) than 3MU group (68.4%) but, the latter had no statistical signifcance (P=0.27). 2) The disappearance rate of HBV-DNA was significantly higher in interferon treated group (72.7%) compared to control group (0%) and it tend to be higher in 3MU group (78.5%) than 5MU group (62.5%) but, the latter had no stastical significance (P=037). 3) The loss rate of HBeAg was significantly higher in interferon treated group (50.0%) compared to control group (O%) and it tend to be higher in 5MU group (66.7%) than 3MU group (37.5%) but, the latter had no stastical significance(P=0.13). 4) Fever (75.8%), leukopenia (41.2%), headache (30.3%), myalgia (18.2%), thrombocytopenia (17.6%), anorexia (11.8%) were noted and fever was significantly higher in 5MU group compared to 3MU group (P=0.02).
Conclusion
The effective improvement of liver function test and disappearance rate of HBeAg tended to be higher in 5MU group than 3MU group, but it was not stastistically significant. Fever was significantly higher in 5MU group compared to 3MU group. (Korean J Hepatol 1998;8:12 - 22)
KeyWords: Chronic active hepatitis - B , interferon , defferent dosage , adverse effect

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