Aerobic Exercise Training Leads to MASH Resolution as Defined by the MASH Resolution Index Theja Channapragada, Sarah Batra, Breianna L. Hummer, Vernon M. Chinchilli, Daniel Huang, Rohit Loomba, Ian R. Schreibman, Jonathan G. Stine Digestive Diseases and Sciences.2025;[Epub] CrossRef
Development of a machine learning-based model to predict hepatic inflammation in chronic hepatitis B patients with concurrent hepatic steatosis: a cohort study Fajuan Rui, Yee Hui Yeo, Liang Xu, Qi Zheng, Xiaoming Xu, Wenjing Ni, Youwen Tan, Qing-Lei Zeng, Zebao He, Xiaorong Tian, Qi Xue, Yuanwang Qiu, Chuanwu Zhu, Weimao Ding, Jian Wang, Rui Huang, Yayun Xu, Yunliang Chen, Junqing Fan, Zhiwen Fan, Xiaolong Qi, eClinicalMedicine.2024; 68: 102419. CrossRef
Functional effects and mechanisms of Phyllanthus emblica fruit and gallic acid on metabolic diseases: Experimental evidence and clinical perspectives Xiaoling Gou, Yin Ding, Yamei Wu, Yiwen Tao, Yaqian Wang, Yue Wang, Jingye Liu, Mi Ma, Xianhua Zhou, Tsedien Nhamdriel, Gang Fan Food Bioscience.2024; 59: 104039. CrossRef
Machine learning based identification potential feature genes for prediction of drug efficacy in nonalcoholic steatohepatitis animal model Marwa Matboli, Ibrahim Abdelbaky, Abdelrahman Khaled, Radwa Khaled, Shaimaa Hamady, Laila M. Farid, Mariam B. Abouelkhair, Noha E. El-Attar, Mohamed Farag Fathallah, Manal S. Abd EL Hamid, Gena M. Elmakromy, Marwa Ali Lipids in Health and Disease.2024;[Epub] CrossRef
Alcoholic and non-alcoholic liver diseases begin from an imbalance in lipid metabolism in hepatocytes as the earliest response. Both liver diseases share common disease features and stages (i.e., steatosis, hepatitis, cirrhosis, and hepatocellular carcinoma). However, the two diseases have differential pathogenesis and clinical symptoms. Studies have elucidated the molecular basis underlying similarities and differences in the pathogenesis of the diseases; the factors contributing to the progression of liver diseases include depletion of sulfhydryl pools, enhanced levels of reactive oxygen and nitrogen intermediates, increased sensitivity of hepatocytes to toxic cytokines, mitochondrial dysfunction, and insulin resistance. Endoplasmic reticulum (ER) stress, which is caused by the accumulation of misfolded proteins and calcium depletion, contributes to the pathogenesis, often causing catastrophic cell death. Several studies have demonstrated a mechanism by which ER stress triggers liver disease progression. Autophagy is an evolutionarily conserved process that regulates organelle turnover and cellular energy balance through decomposing damaged organelles including mitochondria, misfolded proteins, and lipid droplets. Autophagy dysregulation also exacerbates liver diseases. Thus, autophagy-related molecules can be potential therapeutic targets for liver diseases. Since ER stress and autophagy are closely linked to each other, an understanding of the molecules, gene clusters, and networks engaged in these processes would be of help to find new remedies for alcoholic and non-alcoholic liver diseases. In this review, we summarize the recent findings and perspectives in the context of the molecular pathogenesis of the liver diseases.
Citations
Citations to this article as recorded by
Targeting CD44-Hyaluronic Acid Signalling in Obesity Treatment: Insights from Small Molecules and Nanobioconjugates Daniel Ejim Uti, Wilson Achu Omang, Esther Ugo Alum, Okechukwu Paul-Chima Ugwu, Margaret Amieibi Wokoma, Rowland Inalegwu Oplekwu, Item Justin Atangwho, Godwin Eneji Egbung Nutrition and Metabolic Insights.2026;[Epub] CrossRef
The Role of Crosstalk Between the Unfolded Protein Response and Autophagy in Diseases Associated with Sympathetic Nervous System Imbalance: Mechanisms and Therapeutic Perspectives Bo Xu, Yi Yang, Renjun Wang International Journal of Molecular Sciences.2026; 27(3): 1282. CrossRef
Endoplasmic reticulum stress in liver fibrosis: Mechanisms and therapeutic potential Tiantian Wang, Guoqing Xia, Xue Li, Mingxu Gong, Xiongwen Lv Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2025; 1871(3): 167695. CrossRef
Immune Checkpoints and the Immunology of Liver Fibrosis Ioannis Tsomidis, Argyro Voumvouraki, Elias Kouroumalis Livers.2025; 5(1): 5. CrossRef
FAM134B-mediated ER-phagy alleviates alcohol-related liver fibrosis by reducing endoplasmic reticulum stress Tiantian Wang, Xue Li, Guoqing Xia, Mingxu Gong, Xiongwen Lv International Journal of Biological Macromolecules.2025; 308: 142395. CrossRef
Endoplasmic reticulum stress in gut inflammation: Implications for ulcerative colitis and Crohn’s disease Ting Zheng, Kai-Yue Huang, Xu-Dong Tang, Feng-Yun Wang, Lin Lv World Journal of Gastroenterology.2025;[Epub] CrossRef
Chronic Inflammation and Immune Dysregulation in Metabolic-Dysfunction-Associated Steatotic Liver Disease Progression: From Steatosis to Hepatocellular Carcinoma Young-Min Jee, Jeong-Yoon Lee, Tom Ryu Biomedicines.2025; 13(5): 1260. CrossRef
Changing complexity into simplicity: visualization of endoplasmic reticulum autophagy employing a self-deliver viscosity sensor by lifetime imaging Nan Sheng, Jie Niu, Xingyu Lyu, Yangang Su, Qing Lyu, Wendong Jin, Miao Cheng, Jiaxuan Wang, Li Li, Xiaoqiang Yu Biosensors and Bioelectronics.2025; 286: 117596. CrossRef
Targeting endoplasmic reticulum proteostasis in liver fibrosis: From signaling mechanisms to therapeutic opportunities Yawei Kong, Zhengyang Chen, Zhentian Nie, Wei Chen Pharmacological Research.2025; 217: 107823. CrossRef
Morin: a promising hepatoprotective agent against drug and chemical-induced liver injury Anandakumar Pandi, Nabendu Sen, Vanitha Manickam Kalappan, Vanita Lal Naunyn-Schmiedeberg's Archives of Pharmacology.2025; 398(12): 16385. CrossRef
LAPTM4B as a key regulator in the copper-induced endoplasmic reticulum–lysosome interplay disorder in duck liver and the protective role of baicalin Hongyu Shang, Xueyan Dai, Jing Chen, Chenghong Xing, Xiaona Gao, Huabin Cao, Guoliang Hu, Haotang Li, Mingwen Hu, Fan Yang Journal of Animal Science and Biotechnology.2025;[Epub] CrossRef
Chaize mixture alleviates NAFLD by regulating Glipr2-related autophagy/NLRP3 signaling Xiaohui Zhang, Juan Shi, Yutong Liu, Yun Lu, Jing Ji, Xueqian Wang, Jinying Liu, Fafeng Cheng, Qiuxia Zhang, Chongyang Ma International Immunopharmacology.2025; 166: 115600. CrossRef
AMPK affects the development of early-stage NAFLD by activating autophagy and fatty acid oxidation Mei-yu Jin, Hao Yu, Qiong Deng, Zhu Wang, Hui Liang Scientific Reports.2025;[Epub] CrossRef
Characterization of aggrephagy-related genes to predict the progression of liver fibrosis from multi-omics profiles Jing Chen, Zi-Cheng Zhou, Yang Yan, Shu-Zhen Wu, Tao Ma, Han Xuan, Ruo-Chun Wang, Chi-Yu Gu, Yi-Heng Liu, Qing-Qing Liu, Si-Jia Ge, Wei Huang, Cui-Hua Lu Biomedical Technology.2024; 5: 46. CrossRef
Upregulation of FAM134B inhibits endoplasmic reticulum stress‐related degradation protein expression and promotes hepatocellular carcinogenesis Houhong Wang, Lu Liu, Huihui Gong, Heng Li Journal of Cellular and Molecular Medicine.2024;[Epub] CrossRef
Dysfunction of autophagy in high-fat diet-induced non-alcoholic fatty liver disease Qiannan Ren, Qiming Sun, Junfen Fu Autophagy.2024; 20(2): 221. CrossRef
Angiotensin II type-2 receptor attenuates liver fibrosis progression by suppressing IRE1α-XBP1 pathway Yue An, Changyong Xu, Wenmin Liu, Ji Jiang, Pengfei Ye, Mei Yang, Weihua Zhu, Jingjing Yu, Manman Yu, Wuyi Sun, Jian Hong, Huan Qiu, Wei Wei, Shihao Zhang Cellular Signalling.2024; 113: 110935. CrossRef
TMT-based quantitative proteomics analysis of Sprague-Dawley rats liver reveals Triphenyltin induced liver damage and lipid metabolism disorders Xijuan Ren, Penghui Mao, Zhi Li, Mingqing Qian, Xinxin Deng, Hui Liu, Li Wang Pesticide Biochemistry and Physiology.2024; 198: 105739. CrossRef
Advances in Research on the Role of Systemic Inflammatory in Mediating Acute-on-Chronic Liver Failure 婷婷 卞 Advances in Clinical Medicine.2024; 14(04): 1447. CrossRef
New insights into the interplay between autophagy, gut microbiota and insulin resistance in metabolic syndrome Jinyue Zhao, Liyun Duan, Jiarui Li, Chensi Yao, Guoqiang Wang, Jia Mi, Yongjiang Yu, Lu Ding, Yunyun Zhao, Guanchi Yan, Jing Li, Zhixuan Zhao, Xiuge Wang, Min Li Biomedicine & Pharmacotherapy.2024; 176: 116807. CrossRef
Ultrastructural and immunohistochemical evaluation of hyperplastic soft tissues surrounding dental implants in fibular jaws Kezia Rachellea Mustakim, Mi Young Eo, Mi Hyun Seo, Hyeong-Cheol Yang, Min-Keun Kim, Hoon Myoung, Soung Min Kim Scientific Reports.2024;[Epub] CrossRef
Mechanistic Insight into the Autophagic and Apoptotic Activity of Kaempferol on Liver Cancer Cells Nidhi Sharma, Meenakshi Gupta, Pragya Anand, Yusuf Akhter, Noura Al-Dayan, Hind Majed, Subhrajit Biswas, Sher Ali, Maryam Sarwat OncoTargets and Therapy.2024; Volume 17: 579. CrossRef
Perfluorooctane sulfonate causes damage to L-02 cells via Wnt/β-catenin signal path and endoplasmic reticulum stress pathway Cui Jiajing, Yan Shuqi, Ma Haoyan, Wang Pingwei, Liu Dongge, Liu Yanping, Chen Qianqian, Fajrin Saleh, Ren Shuping Toxicology and Industrial Health.2024; 40(12): 653. CrossRef
Long Non-Coding RNAs in Non-Alcoholic Fatty Liver Disease; Friends or Foes? Sina Kalantari Soltanieh, Sahar Khastar, Irwanjot Kaur, Abhishek Kumar, Jaya Bansal, Ata Fateh, Deepak Nathiya, Beneen Husseen, Mansour Rajabivahid, Mahmoud Dehghani-Ghorbi, Reza Akhavan-Sigari Cell Biochemistry and Biophysics.2024; 83(1): 279. CrossRef
3PM-guided innovation in treatments of severe alcohol-associated hepatitis utilizing fecal microbiota transplantation Lubomir Skladany, Natalia Kubanek, Svetlana Adamcova Selcanova, Daniela Zilincanova, Daniel Havaj, Karolina Sulejova, Katarina Soltys, Lucia Messingerova, Michal Lichvar, Lukas Laffers, Michal Zilincan, Eva Honsova, Peter Liptak, Peter Banovcin, Jan Bures EPMA Journal.2024; 15(4): 677. CrossRef
Protective effects of sulfated polysaccharides from Enteromorpha intestinalis on oxidative stress, liver iron overload and Ferroptosis in Zebra fish exposed to ethanol Marziyeh Khazaei, Rashid Alijani Ardeshir Biomedicine & Pharmacotherapy.2024; 181: 117715. CrossRef
Effect of aerobic exercise on GRP78 and ATF6 expressions in mice with non-alcoholic fatty liver disease Junhan Li, Lei Huang, Wei Xiong, Chun Gu, Shuling Zhang, Xiali Xue Sports Medicine and Health Science.2023; 5(2): 112. CrossRef
Luteolin ameliorates palmitate-induced lipotoxicity in hepatocytes by mediating endoplasmic reticulum stress and autophagy Chun-Yin Huang, Haw-Wen Chen, Chia-Wen Lo, Yu-Ru Wang, Chien-Chun Li, Kai-Li Liu, Chong-Kuei Lii Food and Chemical Toxicology.2023; 171: 113554. CrossRef
Translational Control of Metabolism and Cell Cycle Progression in Hepatocellular Carcinoma Alessandra Scagliola, Annarita Miluzio, Stefano Biffo International Journal of Molecular Sciences.2023; 24(5): 4885. CrossRef
Peroxisome proliferator-activated receptors as targets to treat metabolic diseases: Focus on the adipose tissue, liver, and pancreas Henrique Souza-Tavares, Carolline Santos Miranda, Isabela Macedo Lopes Vasques-Monteiro, Cristian Sandoval, Daiana Araujo Santana-Oliveira, Flavia Maria Silva-Veiga, Aline Fernandes-da-Silva, Vanessa Souza-Mello World Journal of Gastroenterology.2023; 29(26): 4136. CrossRef
Immune microenvironment changes of liver cirrhosis: emerging role of mesenchymal stromal cells Qiuyun Yi, Jinxian Yang, Ying Wu, Ying Wang, Qiqi Cao, Wen Wen Frontiers in Immunology.2023;[Epub] CrossRef
Stress mechanism involved in the progression of alcoholic liver disease and the therapeutic efficacy of nanoparticles Hiral Aghara, Prashsti Chadha, Devangi Zala, Palash Mandal Frontiers in Immunology.2023;[Epub] CrossRef
Current Advances in the Regulatory Effects of Bioactive Compounds from Dietary Resources on Nonalcoholic Fatty Liver Disease: Role of Autophagy Yue Zhang, Qing Chen, Xiong Fu, Siming Zhu, Qiang Huang, Chao Li Journal of Agricultural and Food Chemistry.2023; 71(46): 17554. CrossRef
Cell-type specific role of autophagy in the liver and its implications in non-alcoholic fatty liver disease Sana Raza, Sangam Rajak, Rajani Singh, Jin Zhou, Rohit A Sinha, Amit Goel World Journal of Hepatology.2023; 15(12): 1272. CrossRef
Xenobiotic-Induced Aggravation of Metabolic-Associated Fatty Liver Disease Julie Massart, Karima Begriche, Anne Corlu, Bernard Fromenty International Journal of Molecular Sciences.2022; 23(3): 1062. CrossRef
The regulatory role and mechanism of autophagy in energy metabolism-related hepatic fibrosis Li-Shuang Hou, Yao-Wen Zhang, Hua Li, Wei Wang, Meng-Lei Huan, Si-Yuan Zhou, Bang-Le Zhang Pharmacology & Therapeutics.2022; 234: 108117. CrossRef
ER Disposal Pathways in Chronic Liver Disease: Protective, Pathogenic, and Potential Therapeutic Targets Caroline C. Duwaerts, Jessica L. Maiers Frontiers in Molecular Biosciences.2022;[Epub] CrossRef
Subcellular delivery of lipid nanoparticles to endoplasmic reticulum and mitochondria Yingying Shi, Zhenyu Luo, Jian You WIREs Nanomedicine and Nanobiotechnology.2022;[Epub] CrossRef
Anti-Hyperlipidemia, Hypoglycemic, and Hepatoprotective Impacts of Pearl Millet (Pennisetum glaucum L.) Grains and Their Ethanol Extract on Rats Fed a High-Fat Diet Nadiah S. Alzahrani, Ghedeir M. Alshammari, Afaf El-Ansary, Abu ElGasim A. Yagoub, Musarat Amina, Ali Saleh, Mohammed Abdo Yahya Nutrients.2022; 14(9): 1791. CrossRef
Nonalcoholic fatty liver disease and accelerated loss of skeletal muscle mass: A longitudinal cohort study Dong Hyun Sinn, Danbee Kang, Mira Kang, Eliseo Guallar, Yun Soo Hong, Kyung Hyun Lee, Jiyeon Park, Juhee Cho, Geum‐Youn Gwak Hepatology.2022; 76(6): 1746. CrossRef
Identifying Autophagy-Related lncRNAs and Potential ceRNA Networks in NAFLD Ziyi Cao, Li Guan, RunZhi Yu, Jie Chen Frontiers in Genetics.2022;[Epub] CrossRef
Protective effect of fucoidan against iron overload and ferroptosis-induced liver injury in rats exposed to alcohol Meilan Xue, Yingjie Tian, Yingzhong Sui, Hui Zhao, Haiqi Gao, Hui Liang, Xia Qiu, Zhanyi Sun, Yi Zhang, Yimin Qin Biomedicine & Pharmacotherapy.2022; 153: 113402. CrossRef
The protective effect of puerarin-loaded mesoporous silicon nanoparticles on alcoholic hepatitis through mTOR-mediated autophagy pathway Xia-xia Zhang, Yan-fei Lang, Xin Li, Zheng Li, You-qing Xu, Hong-qian Chu Biomedical Microdevices.2022;[Epub] CrossRef
Suppression of endoplasmic reticulum stress-associated pathways and hepatocyte apoptosis participates in the attenuation of betulinic acid on alcohol-provoked liver injury in mice Enqi He, Yurong Ma, Li Kong, You Huang, Chunlin Huang, Wenjiang Yang, Jine Yi, Lijuan Zhu Food & Function.2022; 13(22): 11489. CrossRef
Advances in metformin for the treatment of non-alcoholic fatty liver disease in children Qian-Long Wu, Shu-Xin Zeng, Jia-Ying Peng, Yi Yuan, Zhi Zhu, Zi-Chun Xie, Ze-Hong Huang, Jia-Shuan Huang, Jian-Mei Lai, Jin-an Chen, Min-Hua Lin Expert Review of Gastroenterology & Hepatology.2022; 16(9): 863. CrossRef
Netrin-1 attenuates hepatic steatosis via UNC5b/PPARγ-mediated suppression of inflammation and ER stress Sung Woo Choi, Heeseung Oh, Seung Yeon Park, Wonjun Cho, A.M. Abd El-Aty, Nurcan Kilic Baygutalp, Ji Hoon Jeong, Tae Woo Jung Life Sciences.2022; 311: 121149. CrossRef
Non-alcoholic fatty liver disease and liver secretome Muhammad Sohaib Khan, Choongho Lee, Sang Geon Kim Archives of Pharmacal Research.2022; 45(12): 938. CrossRef
Serum milk fat globule-EGF factor 8 protein as a potential biomarker for metabolic syndrome Han Ah Lee, Jihwan Lim, Hyung Joon Joo, Young-Sun Lee, Young Kul Jung, Ji Hoon Kim, Hyunggin An, Hyung Joon Yim, Yoon Tae Jeen, Jong Eun Yeon, Do-Sun Lim, Kwan Soo Byun, Yeon Seok Seo Clinical and Molecular Hepatology.2021; 27(3): 463. CrossRef
Knockdown of Atg7 suppresses Tumorigenesis in a murine model of liver cancer Kyung Joo Cho, Sun Yeong Shin, Hyuk Moon, Beom Kyung Kim, Simon Weonsang Ro Translational Oncology.2021; 14(9): 101158. CrossRef
Endoplasmic Reticulum Stress and Autophagy in the Pathogenesis of Non-alcoholic Fatty Liver Disease (NAFLD): Current Evidence and Perspectives Christina-Maria Flessa, Ioannis Kyrou, Narjes Nasiri-Ansari, Gregory Kaltsas, Athanasios G. Papavassiliou, Eva Kassi, Harpal S. Randeva Current Obesity Reports.2021; 10(2): 134. CrossRef
The emerging age-pattern changes of patients with hepatocellular carcinoma in Korea Yuri Cho, Bo Hyun Kim, Joong-Won Park Clinical and Molecular Hepatology.2023; 29(1): 99. CrossRef
Impact of metabolic risk factors on hepatic and cardiac outcomes in patients with alcohol- and non-alcohol-related fatty liver disease Jihye Lim, Hyunji Sang, Ha Il Kim JHEP Reports.2023; 5(6): 100721. CrossRef
Surveillance for hepatocellular carcinoma: It is time to move forward Bo Hyun Kim, Yuri Cho, Joong-Won Park Clinical and Molecular Hepatology.2022; 28(4): 810. CrossRef
Metformin and Dichloroacetate Suppress Proliferation of Liver Cancer Cells by Inhibiting mTOR Complex 1 Tae Suk Kim, Minjong Lee, Minji Park, Sae Yun Kim, Min Suk Shim, Chea Yeon Lee, Dae Hee Choi, Yuri Cho International Journal of Molecular Sciences.2021; 22(18): 10027. CrossRef
Serum Myostatin Predicts the Risk of Hepatocellular Carcinoma in Patients with Alcoholic Cirrhosis: A Multicenter Study Ji Hyun Kim, Seong Hee Kang, Minjong Lee, Gi Soo Youn, Tae Suk Kim, Baek Gyu Jun, Moon Young Kim, Young Don Kim, Gab Jin Cheon, Dong Joon Kim, Soon Koo Baik, Dae Hee Choi, Ki Tae Suk Cancers.2020; 12(11): 3347. CrossRef
Non-alcoholic steatohepatitis (NASH) is the more aggressive form of non-alcoholic fatty liver disease (NAFLD). NASH can progress to hepatic fibrosis, cirrhosis, portal hypertension and primary liver cancer. Therapy is evolving with a substantial number of trials of promising new agents now in progress. In this article however, we will examine data for several older forms of therapy which have been fairly extensively studied over the years: Polyunsaturated Fatty Acid (PUFA) supplements, vitamin E, insulin sensitizing agents with a focus on pioglitazone and statin agents. Early interest in PUFA derived from their potential benefit in cardio-metabolic disease and the close association of NAFLD/NASH with Metabolic Syndrome. Results have been variable although most studies show reduction of liver fat without other major effects and their effects are influenced by concomitant weight loss and underlying genetic factors. Vitamin E has had some efficacy in pediatric NASH but questionable efficacy in even mild NASH among adults. Pioglitazone has shown significant histological benefit in a number of trials but concern over side-effects (especially weight gain) have dampened enthusiasm. A newer insulin sensitizer, liraglutide, has also shown promise in a small randomized, controlled trial. Very limited data exists regarding the histological effects of the statins in NASH and these agents appear to be fairly neutral with neither clear cut benefit nor detriment. Their use is best guided by cardiovascular risks rather than liver histology.
Citations
Citations to this article as recorded by
Liver metabolism in human MASLD: A review of recent advancements using human tissue metabolomics Emily Flam, Joel T. Haas, Bart Staels Atherosclerosis.2025; 400: 119054. CrossRef
Multifaceted Interactions Between Bile Acids, Their Receptors, and MASH: From Molecular Mechanisms to Clinical Therapeutics Xuan Tang, Yuanjiao Zhou, Li Xia, Xiulian Lin, Yao Zhu, Menghan Chen, Jiayao Wang, Yamei Li Molecules.2025; 30(15): 3066. CrossRef
Dietary Omega-3 Fatty Acids from Fish and Risk of Metabolic Dysfunction-Associated Steatotic Liver Disease in a Mediterranean Population: Findings from the NUTRIHEP Cohort Rossella Tatoli, Bonfiglio Caterina, Rossella Donghia, Pasqua Letizia Pesole, Luigi Fontana, Gianluigi Giannelli Nutrients.2025; 17(21): 3372. CrossRef
Unlocking the Therapeutic Potential of Ellagic Acid for Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis Tharani Senavirathna, Armaghan Shafaei, Ricky Lareu, Lois Balmer Antioxidants.2024; 13(4): 485. CrossRef
Effectiveness of the ALT/AST ratio for predicting insulin resistance in a Korean population: A large-scale, cross-sectional cohort study Seul Ki Han, Myung Jae Seo, Taesic Lee, Moon Young Kim, Anna Di Sessa PLOS ONE.2024; 19(5): e0303333. CrossRef
Influence of Lipid Class Used for Omega-3 Fatty Acid Supplementation on Liver Fat Accumulation in MASLD I Sabinari, O Horakova, T Cajka, V Kleinova, MR Wieckowski, M Rossmeisl Physiological Research.2024; (Suppl 1): S295. CrossRef
Statins for the Treatment of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis: A Systematic Review and Meta-Analysis Weiwei Dai, Baohong Xu, Peng Li, Junhua Weng American Journal of Therapeutics.2023; 30(1): e17. CrossRef
Hepatitis C and Nonalcoholic Steatohepatitis in the 21st Century: Impact on Liver Disease and Liver Transplantation Sonia Samuel, Ahmad Abulawi, Raza Malik Gastroenterology Insights.2023; 14(3): 249. CrossRef
Omega‐3 phospholipids and obesity‐associated NAFLD: Potential mechanisms and therapeutic perspectives Marko Mitrovic, Gabriella Sistilli, Olga Horakova, Martin Rossmeisl European Journal of Clinical Investigation.2022;[Epub] CrossRef
Enfermedad hepática grasa relacionada a trastornos metabólicos A. Fabrizzio Bardales Silva Revista Médica Basadrina.2022; 15(4): 85. CrossRef
Lower serum copper concentrations are associated with higher prevalence of nonalcoholic steatohepatitis: a matched case–control study Huai Zhang, Kenneth I. Zheng, Pei-Wu Zhu, Sui-Dan Chen, Gang Li, Hong-Lei Ma, Liang-Jie Tang, Ou-Yang Huang, Christopher D. Byrne, Giovanni Targher, Xiao-Dong Wang, Ming-Hua Zheng European Journal of Gastroenterology & Hepatology.2022; 34(8): 838. CrossRef
Mitochondrial Dysfunction Plays Central Role in Nonalcoholic Fatty Liver Disease Raghu Ramanathan, Ahmad Hassan Ali, Jamal A. Ibdah International Journal of Molecular Sciences.2022; 23(13): 7280. CrossRef
Gender differences in the efficacy of pioglitazone treatment in nonalcoholic fatty liver disease patients with abnormal glucose metabolism Hongmei Yan, Weiyun Wu, Xinxia Chang, Mingfeng Xia, Sicheng Ma, Liu Wang, Jian Gao Biology of Sex Differences.2021;[Epub] CrossRef
Fructose intake is not associated to the risk of hepatic fibrosis in patients with Non-Alcoholic Fatty Liver Disease (NAFLD) Vittoria Zambon Azevedo, Valesca Dall’Alba Clinical Nutrition.2021; 40(6): 4275. CrossRef
Effect of Coffee Consumption on Non-Alcoholic Fatty Liver Disease Incidence, Prevalence and Risk of Significant Liver Fibrosis: Systematic Review with Meta-Analysis of Observational Studies Maryam Ebadi, Stephen Ip, Rahima A. Bhanji, Aldo J. Montano-Loza Nutrients.2021; 13(9): 3042. CrossRef
Association between the Severity of Nonalcoholic Fatty Liver Disease and the Risk of Coronary Artery Calcification Chien-Chih Chen, Wei-Chien Hsu, Han-Ming Wu, Jiun-Yi Wang, Pei-Yu Yang, I-Ching Lin Medicina.2021; 57(8): 807. CrossRef
Statins in Non-alcoholic Steatohepatitis Jose D. Torres-Peña, Laura Martín-Piedra, Francisco Fuentes-Jiménez Frontiers in Cardiovascular Medicine.2021;[Epub] CrossRef
Real-world Comorbidity Burden, Health Care Utilization, and Costs of Nonalcoholic Steatohepatitis Patients With Advanced Liver Diseases Robert J. Wong, Nandita Kachru, Diane J. Martinez, Meghan Moynihan, A. Burak Ozbay, Stuart C. Gordon Journal of Clinical Gastroenterology.2021; 55(10): 891. CrossRef
iTRAQ‑based quantitative proteomics analysis of the hepatoprotective effect of melatonin on ANIT‑induced cholestasis in rats Dingnan Wang, Han Yu, Yunzhou Li, Zongying Xu, Shaohua Shi, Dou Dou, Lili Sun, Zhili Zheng, Xinghua Shi, Xiulan Deng, Xianggen Zhong Experimental and Therapeutic Medicine.2021;[Epub] CrossRef
Nonalcoholic Fatty Liver Disease: Pathogenesis and Treatment in Traditional Chinese Medicine and Western Medicine Tingting Shi, Li Wu, Wenjun Ma, Liping Ju, Minghui Bai, Xiaowei Chen, Shourong Liu, Xingxin Yang, Junping Shi, Svein Haavik Evidence-Based Complementary and Alternative Medicine.2020;[Epub] CrossRef
Gut microbial fatty acid metabolites (KetoA and KetoC) affect the progression of nonalcoholic steatohepatitis and reverse cholesterol transport metabolism in mouse model Neng Tanty Sofyana, Jiawen Zheng, Yuki Manabe, Yuta Yamamoto, Shigenobu Kishino, Jun Ogawa, Tatsuya Sugawara Lipids.2020; 55(2): 151. CrossRef
Impact of the Co-Administration of N-3 Fatty Acids and Olive Oil Components in Preclinical Nonalcoholic Fatty Liver Disease Models: A Mechanistic View Rodrigo Valenzuela, Luis A. Videla Nutrients.2020; 12(2): 499. CrossRef
Healthcare resource utilization and costs of nonalcoholic steatohepatitis patients with advanced liver disease in Italy Salvatore Petta, Jie Ting, Stefania Saragoni, Luca Degli Esposti, Sanatan Shreay, Maria Letizia Petroni, Giulio Marchesini Nutrition, Metabolism and Cardiovascular Diseases.2020; 30(6): 1014. CrossRef
Hospitalization costs and risk of mortality in adults with nonalcoholic steatohepatitis: Analysis of a French national hospital database Jérôme Boursier, Sanatan Shreay, Cecile Fabron, Elodie Torreton, Jeremy Fraysse EClinicalMedicine.2020; 25: 100445. CrossRef
Ethyl Acetate Fraction of Amomum xanthioides Ameliorates Nonalcoholic Fatty Liver Disease in a High-Fat Diet Mouse Model Hwi-Jin Im, Seung-Ju Hwang, Jin-Seok Lee, Sung-Bae Lee, Ji-Yun Kang, Chang-Gue Son Nutrients.2020; 12(8): 2433. CrossRef
Nonalcoholic Fatty Liver Disease: A Drug Revolution Is Coming Soung Won Jeong Diabetes & Metabolism Journal.2020; 44(5): 640. CrossRef
Nonalcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis: Current Issues and Future Perspectives in Preclinical and Clinical Research Clarissa Berardo, Laura Giuseppina Di Pasqua, Marta Cagna, Plinio Richelmi, Mariapia Vairetti, Andrea Ferrigno International Journal of Molecular Sciences.2020; 21(24): 9646. CrossRef
A round trip from nonalcoholic fatty liver disease to diabetes: molecular targets to the rescue? Amedeo Lonardo, Simonetta Lugari, Stefano Ballestri, Fabio Nascimbeni, Enrica Baldelli, Mauro Maurantonio Acta Diabetologica.2019; 56(4): 385. CrossRef
Ameliorative effect of Silybin on bisphenol A induced oxidative stress, cell proliferation and steroid hormones oxidation in HepG2 cell cultures Stefania Lama, Daniela Vanacore, Nadia Diano, Carla Nicolucci, Sonia Errico, Marcello Dallio, Alessandro Federico, Carmelina Loguercio, Paola Stiuso Scientific Reports.2019;[Epub] CrossRef
Docosahexaenoic acid and hydroxytyrosol co‐administration fully prevents liver steatosis and related parameters in mice subjected to high‐fat diet: A molecular approach Sandra A. Soto‐Alarcón, Macarena Ortiz, Paula Orellana, Francisca Echeverría, Andrés Bustamante, Alejandra Espinosa, Paola Illesca, Daniel Gonzalez‐Mañán, Rodrigo Valenzuela, Luis A. Videla BioFactors.2019; 45(6): 930. CrossRef
The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis Yan-Xiao Ji, Zan Huang, Xia Yang, Xiaozhan Wang, Ling-Ping Zhao, Pi-Xiao Wang, Xiao-Jing Zhang, Michele Alves-Bezerra, Lin Cai, Peng Zhang, Yue-Xin Lu, Lan Bai, Mao-Mao Gao, Huan Zhao, Song Tian, Yong Wang, Zhi-Xiang Huang, Xue-Yong Zhu, Yan Zhang, Jun Go Nature Medicine.2018; 24(2): 213. CrossRef
Prevention and management of gastroesophageal varices Yeon Seok Seo Clinical and Molecular Hepatology.2018; 24(1): 20. CrossRef
Omega-3 fatty acids and non-alcoholic fatty liver disease: Evidence of efficacy and mechanism of action Eleonora Scorletti, Christopher D. Byrne Molecular Aspects of Medicine.2018; 64: 135. CrossRef
NAFLD and HIV: Do Sex, Race, and Ethnicity Explain HIV-Related Risk? Subada Soti, Kathleen E. Corey, Jordan E. Lake, Kristine M. Erlandson Current HIV/AIDS Reports.2018; 15(3): 212. CrossRef
Fibrogenic Disorders in Human Diseases: From Inflammation to Organ Dysfunction Lucienne Juillerat-Jeanneret, John-David Aubert, Josip Mikulic, Dela Golshayan Journal of Medicinal Chemistry.2018; 61(22): 9811. CrossRef
Dietary Melatonin Supplementation Could Be a Promising Preventing/Therapeutic Approach for a Variety of Liver Diseases Francesca Bonomini, Elisa Borsani, Gaia Favero, Luigi F. Rodella, Rita Rezzani Nutrients.2018; 10(9): 1135. CrossRef
First
Prev
