Hepatic ischemia‒reperfusion injury (HIRI) is a common and inevitable complication of hepatic trauma, liver resection, or liver transplantation. It contributes to postoperative organ failure or tissue rejection, eventually affecting patient prognosis and overall survival. The pathological mechanism of HIRI is highly complex and has not yet been fully elucidated. The proposed underlying mechanisms include mitochondrial damage, oxidative stress imbalance, abnormal cell death, immune cell hyperactivation, intracellular inflammatory disorders and other complex events. In addition to serious clinical limitations, available antagonistic drugs and specific treatment regimens are still lacking. Therefore, there is an urgent need to not only clarify the exact etiology of HIRI but also reveal the possible reactions and bottlenecks of existing drugs, helping to reduce morbidity and shorten hospitalizations. We analyzed the possible underlying mechanism of HIRI, discussed various outcomes among different animal models and explored neglected potential therapeutic strategies for HIRI treatment. By thoroughly reviewing and analyzing the literature on HIRI, we gained a comprehensive understanding of the current research status in related fields and identified valuable references for future clinical and scientific investigations.
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Citations to this article as recorded by
Role of mitochondria-associated endoplasmic reticulum membranes in hepatic ischemia-reperfusion injury: Molecular architecture, pathological remodeling, and therapeutic prospects Luo He, Ting Yang, Zhengda Lou, Junfeng Luo Tissue and Cell.2027; 104: 103939. CrossRef
Emerging nano/micro drug delivery system for hepatic ischemia-reperfusion injury Xiao Fu, Wanqi Yang, Dongxue Ge, Haozhen Ren Coordination Chemistry Reviews.2026; 549: 217357. CrossRef
Artesunate reduces oxidative stress and inflammation in NAFLD by activating the Nrf2 pathway Qinyu Meng, Mengru Zhong, Jiangrong Zhao, Hong Xu, Wentao Jiang, Chenru Lin, Ghaffar Karishma, Feng Wang, Fang Xu, Yana Li Biochemical Pharmacology.2026; 245: 117643. CrossRef
Ubiquitination of Rhomboid 5 Homolog 2 by Constitutive Photomorphogenic 1 Alleviates Hepatic Ischemia-reperfusion Injury by Regulating the Transforming Growth Factor-β Activating Kinase 1-C-Jun N-terminal Kinase/p38 Signaling Pathway Wendong Li, Tongtong Wu, Hao Li, Zhenyu Guan, Mingjie Ding, Wenzhi Guo Cellular and Molecular Gastroenterology and Hepatology.2026; 20(4): 101695. CrossRef
A Multifunctional Nanoplatform for Treating Hepatic Ischemia–Reperfusion Injury by Modulating the Nrf2 and NF-κB Pathways Ling Shuai, Xiaojun Wang, Xudong Wen, Cong Peng, Tian Dong, Jiejuan Lai, Ling Yao, Shijun Fan, Changchun Zhao, Leida Zhang, Yujun Zhang, Xiang Xiong ACS Applied Materials & Interfaces.2026;[Epub] CrossRef
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Rutin ameliorates hepatic ischemia-reperfusion injury by targeting CD36 to suppress hepatocyte ferroptosis Zhenlong Liu, Miaomiao Wang, Liangyun Li, Wenmei Zhang, Wenna Meng, Chengjiang Cao, Hehang Song, Xue Fang, Yan Zhu, Ming Yang, Changlin Du, Yuan Zhang, Cheng Huang, Taotao Ma, Jun Li International Immunopharmacology.2026; 172: 116231. CrossRef
The role of gasdermin D-mediated pyroptosis in hepatic ischemia–reperfusion injury and prediction of the therapeutic natural products Xi Chen, Binhui Wang, Wanqian Li, Nan Jin, Guran Lu, Jiabing Wang Biochemical Pharmacology.2026; 247: 117763. CrossRef
A Visible/NIR-II Dual-Channel Fluorescent Probe for Investigating the Roles of NLRP3 Inflammasome and Ferroptosis during Hepatic Ischemia-Reperfusion Injury Jing-Jing Chao, Li-Yuan Chen, Jing Chen, Yu-Xin Ding, Guo-Jiang Mao, Liufang Hu, Juan Ouyang, Chun-Yan Li Analytical Chemistry.2026; 98(6): 5159. CrossRef
Leonurine Attenuates Ischemia–Reperfusion Injury Through PI3K/AKT/mTOR Pathway in Mouse Liver Pengru Wang, Xin Hu, Haiyan Pu, Junjie Bai, Lei Sun, Tingting Ma, Yichao Du, Wenguang Fu Phytotherapy Research.2026; 40(5): 2230. CrossRef
Nanomedicine as core enablers: Mechanisms of mitophagy and theranostic strategies in ischemia-reperfusion injury Siyu Zhou, Xiaowen Wang, Jiangling Zhu, Jingcun Zheng, Xinran Song, Bingcang Huang, Yu Chen Nano Today.2026; 68: 103005. CrossRef
Experimental and Clinical Transplantation.2026;[Epub] CrossRef
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Advances in basic research on post-cardiac arrest syndrome in adults: a comprehensive review Rui Liu, Junlong Wang Frontiers in Medicine.2026;[Epub] CrossRef
Identification of key genes in the pathogenesis of hepatic ischemia-reperfusion injury based on bioinformatics and experimental verification Tao Zhang, Zhixian Jiang, Qingqing Zhao, Junyi Qiu, Qin Xiong, Shi Zuo Scientific Reports.2026;[Epub] CrossRef
SAA/FPR2 Signaling Between Pericentral Hepatocytes and Macrophages Exacerbates Zonated Liver Transplant Injury Feng Zhang, Rong Li, Tingting Wang, Jianhao Zhang, Zhengqi Wu, Qiang You, Xuying Liu, Cuicui Xiao, Jiebin Zhang, Haitian Chen, Jiaqi Xiao, Jia Yao, Jun Zheng, Yingcai Zhang, Hua Li, Shuhong Yi, Yang Yang, Qi Zhang, Xiaofeng Yuan, Yasong Liu Advanced Science.2026;[Epub] CrossRef
The pathogenesis and treatment strategies of lower extremity ischemia–reperfusion injury Qi Shuai, Zhiyu Guan, Wenlong Yang, Jun Tian, Santing Huang European Journal of Medical Research.2026;[Epub] CrossRef
Acteoside mitigates hepatic ischemia-reperfusion injury by targeting CMPK2-intervened redox metabolism Ranyi Luo, Yun Yang, Xiaoyu Che, Ranyun Chen, Yinhao Zhang, Runping Liu, Wenqian Kang, Le Wang, Yuanfeng Dou, Xiaojiaoyang Li Targetome.2026;[Epub] CrossRef
Rutin as a Potential Therapeutic Agent for Multi-Organ Ischemia–Reperfusion Injury: From Multidimensional Mechanisms to Clinical Translation Quan Peng, Yancheng Zhong, Xiaoxu Yang, Mei Yang, Xihua Cheng, Guozuo Wang Molecules.2026; 31(7): 1070. CrossRef
Brg1 interacts with liver X receptor and H3K18la to regulate ferroptosis via the CYP4A14/20-HETE axis in liver transplantation Haiyang Peng, Changlin Tang, Minjie Zhao, Zheng Qin, Jianping Gong, Xuesong Xu, Junhua Gong American Journal of Transplantation.2026; 26(8): 1818. CrossRef
Ursolic acid mitigates hepatic ischemia-reperfusion injury by regulating the ALOX12/12(S)-HETE and PTGES/prostaglandin E2 axis via arachidonic acid metabolism pathway Wen Hou, Jiansen Lu, Hao Pan, Huanyu Wang, Xuequan Feng, Hongsheng Liu Frontiers in Pharmacology.2026;[Epub] CrossRef
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Mitophagy in Hepatic Ischemia–Reperfusion Injury: From Mitochondrial Dysfunction to Therapeutic Targeting Xinlei Zou, Tianjie Zhang, Nan Wang, Yuanyue Li, Xingming Jiang, Xiangyu Zhong Biomolecules.2026; 16(7): 941. CrossRef
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The emerging role of neutrophil extracellular traps in liver diseases: a narrative review Lanbao Ye, Yan Chen, Zefeng Liu, Junfeng Ye, Wengang Chai Medical Molecular Morphology.2026;[Epub] CrossRef
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in Hepatic Ischemia–Reperfusion Injury Cong Fang, Qi Xie, Lei Peng, Feng Liu, Youyu Zhang, Xiaohua Zhu, Haitao Li Analytical Chemistry.2026; 98(33): 24521. CrossRef
Therapeutic potential of tanshinones in ischaemia–reperfusion injury: Bioactive analogues, pharmacology and mechanisms Meijie Dai, Yimu Zhang, Chenze Zhu, Yuyan Yang, Sunliang Cui, Xiangnan Zhang British Journal of Pharmacology.2026;[Epub] CrossRef
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Background/Aims The shortage of donor liver hinders the development of liver transplantation. This study aimed to clarify the poor outcomes of functionally marginal liver grafts (FMLs) and provide evidence for the improvement of ischemia-free liver transplantation (IFLT) after FML transplantation.
Methods Propensity score matching was used to control for confounding factors. The outcomes of the control group and FML group were compared to demonstrate the negative impact of FMLs on liver transplantation patients. We compared the clinical improvements of the different surgical types. To elucidate the underlying mechanism, we conducted bioinformatic analysis based on transcriptome and single-cell profiles.
Results FMLs had a significantly greater hazard ratio (HR: 1.969, P=0.018) than did other marginal livers. A worse 90-day survival (Mortality: 12.3% vs. 5.0%, P=0.007) was observed in patients who underwent FML transplantation. Patients who received FMLs had a significant improvement in overall survival after IFLT (Mortality: 10.4% vs 31.3%, P=0.006). Pyroptosis and inflammation were inhibited in patients who underwent IFLT. The infiltration of natural killer cells was lower in liver grafts from these patients. Bulk transcriptome profiles revealed a positive relationship between IL-32 and Caspase 1 (R=0.73, P=0.01) and between IL-32 and Gasdermin D (R=0.84, P=0.0012).
Conclusions FML is a more important negative prognostic parameter than other marginal liver parameters. IFLT might ameliorate liver injury in FMLs by inhibiting the infiltration of NK cells, consequently leading to the abortion of IL-32, which drives pyroptosis in monocytes and macrophages.
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Economic impact of graft’s cold ischemia time on infection and post-liver transplant costs DEYVID FERNANDO MATTEI DA-SILVA, OTÁVIO MONTEIRO BECKER JÚNIOR, JANINE SCHIRMER, NACIME SALOMÃO MANSUR, ELIZABETH AKEMI NISHIO, BARTIRA DE AGUIAR ROZA Revista do Colégio Brasileiro de Cirurgiões.2025;[Epub] CrossRef
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The impact of ischemia-free liver transplantation on improving the prognosis of recipients using functionally marginal liver grafts: Editorial on “Ischemia-free liver transplantation improves the prognosis of recipients using functionally marginal liver g Ho Joong Choi Clinical and Molecular Hepatology.2024; 30(4): 702. CrossRef
Donation after circulatory death (DCD) is an increasing source of liver grafts for transplantation, yet outcomes have been inferior compared to donation after brain death liver transplantation. These worse outcomes are mainly due to the severe graft injury resulting from mandatory warm ischemia during DCD organ recovery. New evidence, however, indicates that improved donor selection and surgical techniques can decrease the risk of graft failure and ischemic cholangiopathy (IC). Under current best practices, DCD organs are retrieved with the super-rapid technique, optimizing timing and protecting the liver graft from detrimental warm ischemia. Graft viability is influenced by both the quantity and quality of warm ischemia, which is unique to each donor and causes various degrees of pathophysiologic consequences. Evidence also shows that the choice of preservation solution and premortem heparin administration influences graft viability. Additionally, although the precise mechanism of IC remains unknown, stasis of blood during donor warm ischemia may cause the formation of microthrombi in the peribiliary vascular plexus and ischemia of the bile duct. Importantly, thrombolytic protocols show a possible preventive modality for IC. Finally, while ex vivo machine perfusion technology has gained an interest in DCD liver transplantation, further studies are necessary to evaluate the effectiveness of this evolving field to improve graft quality and transplant outcomes.
Citations
Citations to this article as recorded by
From pixels to prognosis: A comprehensive evidence synthesis on pre-retrieval imaging in deceased and living liver donors Andrea Peloso, Daniel Pietrasz, Charles-Henry Wassmer, Edoardo Maria Muttillo, Beat Moeckli, Rohan Kumar, François Cauchy, Alexis Ricoeur, Philippe Compagnon, Christian Toso Hepatobiliary & Pancreatic Diseases International.2026; 25(3): 243. CrossRef
Experimental and Clinical Transplantation.2026;[Epub] CrossRef
A pilot, two-center, sequential dose escalation safety study of alteplase with fresh frozen plasma during normothermic liver perfusion Christopher J.E. Watson, Stephen Macdonald, Danielle White, Christopher Bridgeman, Rohit Gaurav, Lisa Swift, Rachel Webster, Satheesh Iype, Keziah Crick, Joerg-Matthias Pollok, Carlo D.L. Ceresa, Subhankar Paul, Jack Martin, Sara S. Upponi, Ian Currie, Th Liver Transplantation.2026; 32(7): 978. CrossRef
Current Understanding of Marginal Grafts in Liver Transplantation Ze Xiang, Jiarui Li, Huixuan Zeng, Xiaonan Xiang, Fengqiang Gao, Kai Wang, Xuyong Wei, Shusen Zheng, Xiao Xu Aging and disease.2025; 16(2): 1036. CrossRef
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Background/Aims We measured changes in mitochondrial function and bioenergetics that occur during ischemia/ reperfusion in fresh liver samples of patients undergoing liver transplantation. These variations correlated with markers of liver function and clinical outcome. Ischemia/reperfusion injury related to liver transplantation affects mitochondrial function and bioenergetics. Experimental studies were conducted to identify the role of bioenergetics and mitochondrial dysfunction. To the best of our knowledge, no investigation of these two factors’ impacts on liver transplantation has been performed.
Methods This was a prospective study of 28 patients who underwent liver transplantation. We measured parameters of mitochondrial function and bioenergetics in biopsies performed during the procedure.
Results We observed a statistically significant reduction in mitochondrial membrane potential, an increase in lag phase, and decreases in mitochondrial respiration and adenosine triphosphate content (P<0.010). Higher postoperative aminotransferase peaks correlated with worse mitochondrial function; mitochondrial respiration correlated with arterial lactate (P<0.010).
Conclusions There is a relationship between mitochondrial function and ischemia/reperfusion injury. The future use of these clinical markers as prognostic factors may allow early identification of post-transplant liver failure and may indicate the need to perform a new transplant.
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Background / Aim : The lipo-PGE1, known for being more stable during pulmonary circulation and having more targeting effect, has been reported to inhabit ET-1 induced stellate cell contraction. We assessed the effect of lipo-PGE1 on the change of ET-1 concentration and the relationship between ET-1 concentration and the liver damage. Methods : Mongrel dogs weighting about 25kg were divided into a control(n=6) and a lipo-PGE1 (n=6)group. Partial liver allotransplantation was performed. In the lipo-PGE1 group, lipo-PGE1 was slowly infused (60 ㎍/day) for 48 hours after reperfusion. The AST,ALP,LDH and ET-1 concentrations were monitored Results : The AST and ALP levels of the lipo-PGE1 group were significantly lower than those of the control group both at 1 hour and 48 hours after reperfusion. The LDH level in the lipo-PGE1 group was lower at 1 hour and 48 hours after reperfusion. But there was no statistical difference between the two groups. The baseline ET-1 concentration was elevated gradually in the control group. There was no significant difference between the two groups at 48 hours. There was no correlation between ET-1 concentrations and AST , ALP,LDH levels. Conclusion : This study demonstrated the hepatoprotective effect of the lipo-PGE1 against ischemia-reperfusion injury in canine partial liver allotransplantation. However, the baseline ET-1 level was eight tomes higher in the lipo-PGE1 group than that of the comntrol group in spite of the hepatoprotective effects of the lipo-PGE1. (Korean J Hepatol 2001;7 :475- 484)
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