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Alcohol is a well-known risk factor for premature morbidity and mortality. The per capita alcohol consumption of the world’s population rose from 5.5 L in 2005 to 6.4 L in 2010 and was still at the level of 6.4 L in 2016. Alcohol-attributable deaths and disability-adjusted life years (DALYs) declined from 2000 to 2016 by 17.9% and 14.5%, respectively. However, these gains observed in the alcohol-attributable burden have proportionally not kept pace with the total health gains during the same period. In 2016, 3.0 million deaths worldwide and 132 million DALYs were attributable to alcohol, responsible for 5.3% of all deaths and 5.0% of all DALYs. These burdens are the highest in the regions of Eastern Europe and sub-Saharan Africa. The alcohol-attributable burden is particularly heavy among young adults, accounting for 7.2% of all premature mortalities. Among the disease categories to which alcohol is related, injuries, digestive diseases, and cardiovascular diseases are the leading causes of the alcohol-attributable burden. To reduce the harmful use of alcohol in a country, the ‘whole of government’ and ‘whole of society’ approaches are required with the implementation of evidence-based alcohol control policies, the pursuit of public health priorities, and the adoption of appropriate policies over a long period of time. In this review, we summarize previous efforts to investigate the alcohol-attributable disease burden and the best ways to protect against harmful use of alcohol and promote health.
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Inter-professional and inter-departmental alcoholism rehabilitation program Masahiro Kikuchi, Naomi Matsutani, Ryota Ishihara, Masako Sugihara, Yuuki Mizuno, Chiyo Chiba, Takahiro Ohta, Eri Yamada, Sota Oguro, Yasuko Sato, Hiroki Bessho, Yoshinori Horie Clinical and Molecular Hepatology.2020; 26(4): 626. CrossRef
Serum Myostatin Predicts the Risk of Hepatocellular Carcinoma in Patients with Alcoholic Cirrhosis: A Multicenter Study Ji Hyun Kim, Seong Hee Kang, Minjong Lee, Gi Soo Youn, Tae Suk Kim, Baek Gyu Jun, Moon Young Kim, Young Don Kim, Gab Jin Cheon, Dong Joon Kim, Soon Koo Baik, Dae Hee Choi, Ki Tae Suk Cancers.2020; 12(11): 3347. CrossRef
Alcohol Use Disorders and Increased Risk of Adverse Birth Complications and Outcomes: An 11-Year Nationwide Cohort Study Sarah Soyeon Oh, Yongho Jee, Eun-Cheol Park, Young Ju Kim International Journal of Environmental Research and Public Health.2020; 17(22): 8515. CrossRef
CX3CR1 differentiates F4/80low monocytes into pro-inflammatory F4/80high macrophages in the liver Young-Sun Lee, Myung-Ho Kim, Hyon-Seung Yi, So Yeon Kim, Hee-Hoon Kim, Ji Hoon Kim, Jong Eun Yeon, Kwan Soo Byun, Jin-Seok Byun, Won-Il Jeong Scientific Reports.2018;[Epub] CrossRef
Validation of modified fibrosis-4 index for predicting hepatocellular carcinoma in patients with compensated alcoholic liver cirrhosis Ji Hyun Kim, Minjong Lee, Seung Woo Park, Myungho Kang, Minjeong Kim, Sang Hoon Lee, Tae Suk Kim, Jin Myung Park, Dae Hee Choi Medicine.2018; 97(48): e13438. CrossRef
Efficacy of granulocyte colony stimulating factor in patients with severe alcoholic hepatitis with partial or null response to steroid (GRACIAH trial): study protocol for a randomized controlled trial Yuri Cho, Youn Su Park, Hwi Young Kim, Won Kim, Heon Ju Lee, Dong Joon Kim Trials.2018;[Epub] CrossRef
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