Acute hepatitis E virus (HEV) infection is typically self-limiting and has a favourable prognosis. However, certain populations such as patients with pre-existing chronic liver disease may experience severe manifestations, including progression to acute-on-chronic liver failure (ACLF). Among viral hepatitis types, hepatitis A, E, and B are major causes of ACLF. Active screening and early diagnosis of HEV infection in patients with cirrhosis, especially those who develop ACLF, can improve management and enable timely antiviral therapy. Preventive measures, including HEV vaccination for high-risk groups, could reduce the morbidity and mortality associated with hepatitis E.
Citations
Citations to this article as recorded by
Virus de la hepatitis E: un problema de salud pública emergente María Teresa Pérez-Gracia, Lara Martínez-Celdrán, Clara Más-Comes Medicina Clínica.2026; 166(2): 107286. CrossRef
Shellfish as a Potential Source of Hepatitis E Virus: Epidemiological Evidence, Biological Plausibility, and Research Gaps Hiroaki Okamoto Viruses.2026; 18(2): 220. CrossRef
Hepatitis E virus: An emerging public health problem María Teresa Pérez-Gracia, Lara Martínez-Celdrán, Clara Más-Comes Medicina Clínica (English Edition).2026; 166(2): 107286. CrossRef
Clinical characteristics of hospitalized patients with hepatitis E virus infection in Poland: a multi-centre retrospective study Anna Parfieniuk-Kowerda, Jerzy Jaroszewicz, Piotr Grabarczyk, Dorota Zarebska-Michaluk, Katarzyna Sikorska, Anna Piekarska, Aleksandra Berkan-Kawinska, Dorota Kozielewicz, Małgorzata Pawlowska, Monika Pazgan-Simon, Barbara Sobala-Szczygiel, Piotr Zielinsk Advances in Medical Sciences.2026; 71(1): 75. CrossRef
Global Temporal Trends and Projections of Acute Hepatitis E Epidemiology for Adults 65 Years and Older from 1990 to 2021: Global Burden of Disease 2021 Based Study Shuangshuang Ma, Qingling Wang, Junjie Lin, Yufeng Gao Tropical Medicine and Infectious Disease.2026; 11(3): 82. CrossRef
Cholinesterase and the association between hepatic steatosis and liver fibrosis in patients with prior hepatitis E Ziteng Wang, Zhe Yu, Wen An, Herui Wei, Jing Luo, Mengqi Li, Lingling He, Jiali Ma, Fan Xiao, Lijuan Sun, Qi Gao, Hui Zhong, Hongshan Wei European Journal of Medical Research.2026;[Epub] CrossRef
Efficacy and safety of mesenchymal stem cell therapy in acute on chronic liver failure: a systematic review and meta-analysis of randomized controlled clinical trials Wenming Lu, Longxiang Yan, Lulu Peng, Xuesong Wang, Xingkun Tang, Jing Du, Jing Lin, Zhengwei Zou, Lincai Li, Junsong Ye, Lin Zhou Stem Cell Research & Therapy.2025;[Epub] CrossRef
Hepatitis A and E Viruses Are Important Agents of Acute Severe Hepatitis in Asia: A Narrative Review Reina Sasaki-Tanaka, Tatsuo Kanda, Takeshi Yokoo, Hiroyuki Abe, Kazunao Hayashi, Akira Sakamaki, Hiroteru Kamimura, Shuji Terai Pathogens.2025; 14(5): 454. CrossRef
The role of bacterial outer membrane vesicles in inflammatory response of acute-on-chronic liver failure Xiaojing Qin, Shuang Wang, Zhanyao Yan, Ninghui Zhao, Jia Yao Frontiers in Microbiology.2025;[Epub] CrossRef
Ribavirina como tratamiento de hepatitis E aguda grave sobre hepatopatía crónica: experiencia clínica Alba Rabadán Mata, María Dolores Antón Conejero, José María Paredes Arquiola Medicina Clínica.2025; 165(6): 107187. CrossRef
Ribavirin as a treatment for severe acute hepatitis E on chronic liver disease: Clinical experience Alba Rabadán Mata, María Dolores Antón Conejero, José María Paredes Arquiola Medicina Clínica (English Edition).2025; 165(6): 107187. CrossRef
Dynamic CD177/CD10 ratio for infection diagnosis and mortality risk stratification in critically ill patients: a prospective cohort study Jiamin Huang, Keliang Xie, Heyue Li, Xiao Wen, Yiwen Mei, Jiahui Chen, Aixiang Yang, Bingwei Sun eBioMedicine.2026; 123: 106100. CrossRef
Sepsis: Heterogeneity, Immunopathology, and Advances in Therapeutic Strategies Junxing Qu, Peizhi Li, Zhiheng Sun The FASEB Journal.2026;[Epub] CrossRef
RAC1 as a novel therapeutic target for acute liver failure Barbara Bueloni, Esteban Fiore, María José Cantero, Lucia Lameroli, Catalina Atorrasagasti, Matías Ciarlantini, Andrea Barquero, Lucía Gandolfi Donadio, Daiana Ganiewich, Francisco Orozco, Martín Fauda, Julieta Comin, Ali Canbay, Juan Bayo, Guillermo Mazz JHEP Reports.2025; 7(11): 101547. CrossRef
Correspondence to editorial on “Dynamic analysis of acute deterioration in chronic liver disease patients using modified quick sequential organ failure assessment” Do Seon Song, Dong Joon Kim Clinical and Molecular Hepatology.2024; 30(4): 1012. CrossRef
From Liver to Brain: A 2.5D Deep Learning Model for Predicting Hepatic Encephalopathy Using Opportunistic Non-contrast CT in Hepatitis B Related Acute-on-Chronic Liver Failure Patients Zonglin Liu, Xueyun Zhang, Ying Chen, Qi Zhang, Zhenxuan Ma, Yue Wu, Yuxin Huang, Yajie Li, Xi Zhao, Wenchao Gu, Jiaxing Wu, Ying Tao, Yuxin Shi, Zhenwei Yao, Yan Ren, Yuxian Huang, Shiman Wu Journal of Imaging Informatics in Medicine.2026;[Epub] CrossRef
Outcomes of Highly Urgent ABO-Incompatible Living Donor Liver Transplantation in National Databases Jongman Kim, Sang Jin Kim, Boram Park, Kyunga Kim, YoungRok Choi, Geun Hong, Jun Yong Park, Young Seok Han, Nam-Joon Yi, Seung Heui Hong, Soon-Young Kim, Jungbun Park, Youngwon Hwang, Dong-Hwan Jung Journal of Korean Medical Science.2026;[Epub] CrossRef
Emergency living donor liver transplantation Jongman Kim Annals of Liver Transplantation.2025; 5(1): 27. CrossRef
RAC1 as a novel therapeutic target for acute liver failure Barbara Bueloni, Esteban Fiore, María José Cantero, Lucia Lameroli, Catalina Atorrasagasti, Matías Ciarlantini, Andrea Barquero, Lucía Gandolfi Donadio, Daiana Ganiewich, Francisco Orozco, Martín Fauda, Julieta Comin, Ali Canbay, Juan Bayo, Guillermo Mazz JHEP Reports.2025; 7(11): 101547. CrossRef
Akkermansia muciniphila improve cognitive dysfunction by regulating BDNF and serotonin pathway in gut-liver-brain axis Eun Ji Kang, Min-Gi Cha, Goo-Hyun Kwon, Sang Hak Han, Sang Jun Yoon, Sang Kyu Lee, Moo Eob Ahn, Sung-Min Won, Eun Hee Ahn, Ki Tae Suk Microbiome.2024;[Epub] CrossRef
Gut microbiome and metabolome signatures in liver cirrhosis-related complications Satya Priya Sharma, Haripriya Gupta, Goo-Hyun Kwon, Sang Yoon Lee, Seol Hee Song, Jeoung Su Kim, Jeong Ha Park, Min Ju Kim, Dong-Hoon Yang, Hyunjoon Park, Sung-Min Won, Jin-Ju Jeong, Ki-Kwang Oh, Jung A Eom, Kyeong Jin Lee, Sang Jun Yoon, Young Lim Ham, G Clinical and Molecular Hepatology.2024; 30(4): 845. CrossRef
Alterations in the intestinal microbiome and metabolic profile of patients with cirrhosis supplemented with lactulose, Clostridium butyricum, and Bifidobacterium longum infantis: a randomized placebo-controlled trial Haifeng Lu, Xiaofei Zhu, Lingyun Wu, Xiaobin Lou, Xiaxia Pan, Bowen Liu, Hua Zhang, Lingxiao Zhu, Lanjuan Li, Zhongwen Wu Frontiers in Microbiology.2023;[Epub] CrossRef
First
Prev
