Clinical and Molecular Hepatology

"Yasuko Iwakiri"

Editorial

Liver fibrosis, cirrhosis, and portal hypertension

Unlocking the role of liver sinusoidal endothelial cells: Key players in liver fibrosis: Editorial on “Liver sinusoidal endothelial cell: An important yet often overlooked player in the liver fibrosis”: Yasuko Iwakiri; Clin Mol Hepatol 2024;30(4):673-676.
Published online May 10, 2024; DOI: https://doi.org/10.3350/cmh.2024.0343

Citations

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Correspondence to editorial on “Liver sinusoidal endothelial cell: An important yet often overlooked player in the liver fibrosis”
Jiaorong Qu, Le Wang, Xiaojiaoyang Li
Clinical and Molecular Hepatology.2024; 30(4): 1002. CrossRef
Exploring the Role of Peroxisome Proliferator-Activated Receptors and Endothelial Dysfunction in Metabolic Dysfunction-Associated Steatotic Liver Disease
Ana Paula Madariaga Traconis, Misael Uribe-Esquivel, Varenka Julieta Barbero Becerra
Cells.2024; 13(24): 2055. CrossRef

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Special topic: Alcoholic liver diseases
The 14th International Symposium on Alcoholic Liver and Pancreatic Diseases and Cirrhosis (ISALPDC)

Alcohol-related liver disease

The lymphatic system in alcohol-associated liver disease: Reiichiro Kondo, Yasuko Iwakiri; Clin Mol Hepatol 2020;26(4):633-638.
Published online September 21, 2020; DOI: https://doi.org/10.3350/cmh.2020.0179

Abstract
PDF

The lymphatic system plays vital roles in interstitial fluid balance and immune cell surveillance. The effect of alcohol on the lymphatic system is poorly understood. This review article explores the role of the lymphatic system in the pathogenesis of alcohol-related disease including alcoholic liver disease (ALD) and the therapeutic potential of targeting hepatic lymphatics for the treatment of ALD.

Citations

Citations to this article as recorded by

Hepatic Lymphatic System and Its Current Understanding in Liver-Related Pathophysiology
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Lymphatics.2026; 4(1): 5. CrossRef
Inflammation and immunity in liver homeostasis and disease: a nexus of hepatocytes, nonparenchymal cells and immune cells
Enis Kostallari, Robert F. Schwabe, Adrien Guillot
Cellular & Molecular Immunology.2025; 22(10): 1205. CrossRef
Characterization of prokineticin system in Crohn's disease pathophysiology and pain, and its modulation by alcohol abuse: A preclinical study
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Endotheliopathy of liver sinusoidal endothelial cells in liver disease
Reiichiro Kondo, Yasuko Iwakiri, Masayoshi Kage, Hirohisa Yano
Pathology International.2023; 73(9): 381. CrossRef
Translational Value of Tumor-Associated Lymphangiogenesis in Cholangiocarcinoma
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Journal of Personalized Medicine.2022; 12(7): 1086. CrossRef

15,497 View
170 Download
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Reviews

Liver fibrosis, cirrhosis, and portal hypertension

Nitric oxide in liver fibrosis: The role of inducible nitric oxide synthase: Yasuko Iwakiri; Clin Mol Hepatol 2015;21(4):319-325.
Published online December 24, 2015; DOI: https://doi.org/10.3350/cmh.2015.21.4.319

Abstract
PDF

The inducible form of nitric oxide synthase (iNOS) is expressed in hepatic cells in pathological conditions. Its induction is involved in the development of liver fibrosis, and thus iNOS could be a therapeutic target for liver fibrosis. This review summarizes the role of iNOS in liver fibrosis, focusing on 1) iNOS biology, 2) iNOS-expressing liver cells, 3) iNOS-related therapeutic strategies, and 4) future directions.

Citations

Citations to this article as recorded by

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Yutong Lv, Zhe Ma, Yue Chong, Zhenlong Wang, Li Xue, Fu Wang
Materials Horizons.2026; 13(1): 67. CrossRef
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Jin‐Bo Zhao, Gu‐Qing Luo, Zheng‐Hao Wu, Jia‐Yun Lin, Chi‐Hao Zhang, Guang‐Bo Wu, Qiang Fan, Xiao‐Liang Qi, Hai‐Zhong Huo, Ji‐Wei Yu, Hong‐Jie Li, Meng Luo, Lei Zheng
Advanced Healthcare Materials.2026;[Epub] CrossRef
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Hind Zafrah, Saif A. Alqahtani, Fahaid Al-Hashem, Bahjat Al-Ani, Nourah M. Alzamil
Tissue and Cell.2026; 101: 103425. CrossRef
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Fatemeh Mirzaei, Ebrahim Abbasi, Amir Mirzaei, Nashmin Fayazi Hosseini, Nima Naseri, Iraj Khodadadi, Cyrus Jalili, Nesrine Majdoub
Biological Trace Element Research.2025; 203(1): 199. CrossRef
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Jinqiu Ran, Shengxia Yin, Rahma Issa, Qianwen Zhao, Guangqi Zhu, Huan Zhang, Qun Zhang, Chao Wu, Jie Li
Hepatology Communications.2025;[Epub] CrossRef
Exploring Extracellular Vesicles: A Novel Approach in Nonalcoholic Fatty Liver Disease
Andrea del Pilar Abreo Medina, Mengdie Shi, Yanyan Wang, Zhongyu Wang, Kehe Huang, Yunhuan Liu
Journal of Agricultural and Food Chemistry.2025; 73(5): 2717. CrossRef
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Albert Gibert-Ramos, María Andrés-Rozas, Raül Pastó, Pablo Alfaro-Retamero, Sergi Guixé-Muntet, Jordi Gracia-Sancho
Clinical and Molecular Hepatology.2025; 31(1): 32. CrossRef
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Hanjun Mo, Pengfei Yue, Qiaoqi Li, Yinxi Tan, Xinran Yan, Xinyue Liu, Yuanwei Xu, Yingzhe Luo, Suruiya Palihati, Cheng Yi, Hua Zhang, Minlan Yuan, Biao Yang
Angiogenesis.2025;[Epub] CrossRef
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Verena Habermaass, Yuki Takami, Takeshi Izawa, Francesca Abramo, Corrado Biolatti, Veronica Marchetti
Veterinary Sciences.2025; 12(3): 220. CrossRef
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Reham Mokhtar Aman, Randa Ahmed Zaghloul, Noha Mohamed Saleh
Journal of Drug Delivery Science and Technology.2025; 107: 106756. CrossRef
Recent Progress in Small Molecule Fluorescent Probes for Imaging and Diagnosis of Liver Injury
Shuo Liu, Fei Huang, Xinyi Huang, Fuxin Zhang, Dong Pei, Jinlong Zhang, Jun Hai
Targets.2025; 3(2): 18. CrossRef
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Ping Ma, Yu-ju Cai, Hui Dong, Ruo-lan Dong
Chinese Journal of Integrative Medicine.2025; 31(9): 837. CrossRef
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Matheus Scherer Bastos, Kétlin Fernanda Rodrigues, Maria Claudia Rosa Garcia, Carolina Luft, Giovana Vivan Tonial, Giovanna Mezzomo Pavanato, Leandro Vieira Astarita, Barbara Bettanin Gatti, Fábio Luiz Dal Moro Maito, Eliane Romanato Santarém, J.R. de Oli
Toxicon.2025; 264: 108436. CrossRef
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Rui Zeng, Liu Shen, Tingjie Ye, Wei Xu, Kai Huang, Fengjun Qiu, Chenghai Liu, Xudong Hu
Journal of Ethnopharmacology.2025; 351: 120074. CrossRef
Molecular Imaging Probes for Early Detection and Staging of Liver Fibrosis
Xiuqi Hu, Mengdan Xu, Xiao Xiao, Ning Wang, Qianqian Zhang, Jianxian Ge, Jianfeng Zeng
Chemical & Biomedical Imaging.2025; 3(11): 702. CrossRef
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Mak-Soon Lee, Bohyeon Kim, Jumi Lee, Yejie Cho, In-Hwan Kim, Yangha Kim
The Journal of Nutrition.2025; 155(10): 3401. CrossRef
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Atsuko Daikoku, Tsutomu Matsubara, Misako Sato-Matsubara, Miku Ando, Chiho Kadono, Sayuri Takada, Naoshi Odagiri, Hideto Yuasa, Hayato Urushima, Katsutoshi Yoshizato, Norifumi Kawada, Kazuo Ikeda
Biomedicine & Pharmacotherapy.2025; 191: 118520. CrossRef
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Altaf A. Abdulkhaliq, Glowi Alasiri, Johra Khan, Amir Ajoolabady, Jaakko Tuomilehto, Nils Henninger, Suhad Bahijri, Domenico Pratico, Anwar Borai, Bahauddeen M. Alrfaei, Bonglee Kim, Jun Ren
Journal of Cellular Biochemistry.2025;[Epub] CrossRef
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Ana Isabel Galve, Ignacio Garutti, Elena Vara, Guillermo González, Gabriel Cusati, Lisa Rancan, Luis Huerta, Javier Casanova, Carlos Simón
Journal of Personalized Medicine.2025; 15(12): 620. CrossRef
Organelle stress and alterations in interorganelle crosstalk during liver fibrosis
Saloni Sinha, Nora Hassan, Robert E. Schwartz
Hepatology.2024; 79(2): 482. CrossRef
Baccharis anomala DC. extract reduces inflammation and attenuates hepatic fibrosis in vivo by decreasing NF-kB and extracellular matrix compounds
Bruno de Souza Basso, Matheus Scherer Bastos, Géssica Luana Antunes, Lucas Strassburger Matzenbacher, Kétlin Fernanda Rodrigues, Maria Claudia Rosa Garcia, Arieli Cruz de Sousa, Vitor Giancarlo Levorse, Carolina Luft, Giovana Vivan Tonial, Giovanna Mezzom
Toxicon.2024; 237: 107560. CrossRef
Not just fibrotic: endothelial-derived TGFβ maintains contractile function and lymphatic muscle phenotype during homeostasis
Miriam Carrillo Diaz de Leon, Keith Keane, Simon Roizes, Shan Liao, Pierre-Yves von der Weid, Matthew Stephens
American Journal of Physiology-Cell Physiology.2024; 326(1): C269. CrossRef
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Subramanian Raghunandhakumar, Devaraj Ezhilarasan, Karthik Shree Harini
Journal of Biochemical and Molecular Toxicology.2024;[Epub] CrossRef
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Marwa A. Hasby Saad, Esraa G. El‐Saadi, Dareen A. Ali, Mona M. Watany, Mohammed M. Eid
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Jun Zhang, Jing Zhou, Zheyun He, Hongshan Li
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Ankit Kothiya, Neeru Adlakha
Journal of Biological Physics.2024; 50(2): 229. CrossRef
Nitric oxide donor S‐Nitroso‐N‐acetyl penicillamine for hepatic stellate cells to restore quiescence
Junbao Du, Yin He, Wen Jia, Xiaohua Liang, Quan Kang, Yun He
Pediatric Discovery.2024;[Epub] CrossRef
Microarray analysis demonstrates up-regulation of the endothelin-1 gene with compensatory down-regulation of the ETA receptor gene in human portal vein
Nicola E. Owen, Thomas L. Williams, Janet J. Maguire, Rhoda E. Kuc, Emma E. Davenport, Anthony P. Davenport
Bioscience Reports.2024;[Epub] CrossRef
Delivery Strategy to Enhance the Therapeutic Efficacy of Liver Fibrosis via Nanoparticle Drug Delivery Systems
Jie Liu, Jinhu Liu, Weiwei Mu, Qingping Ma, Xiangyu Zhai, Bin Jin, Yongjun Liu, Na Zhang
ACS Nano.2024; 18(32): 20861. CrossRef
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Kyung Eun Kim, Jaewoong Lee, Hyun Joo Shin, Eun Ae Jeong, Hye Min Jang, Yu Jeong Ahn, Hyeong Seok An, Jong Youl Lee, Meong Cheol Shin, Soo Kyoung Kim, Won Gi Yoo, Won Ho Kim, Gu Seob Roh
Hepatology.2023; 77(3): 888. CrossRef
(Poly)phenols and nitrolipids: Relevant participants in nitric oxide metabolism
César G. Fraga, Andrés Trostchansky, Barbara S. Rocha, João Laranjinha, Homero Rubbo, Monica Galleano
Molecular Aspects of Medicine.2023; 89: 101158. CrossRef
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Hepatology.2023; 78(2): 649. CrossRef
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Foteini Athanasopoulou, Michail Manolakakis, Santiago Vernia, Nazila Kamaly
Nanomedicine.2023; 18(1): 67. CrossRef
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Diana K. Ghobrial, Nefertiti El-Nikhely, Eman Sheta, Hanan M. Ragab, Sherif A. F. Rostom, Hesham Saeed, Ahmed Wahid
Antioxidants.2023; 12(3): 637. CrossRef
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Hyunseong Kim, Jinyoung Hong, Junseon Lee, Wanjin Jeon, Changhwan Yeo, Yoonjae Lee, Seungho Baek, Inhyuk Ha
Nutrients.2023; 15(4): 808. CrossRef
Accurate diagnosis of hepatic fibrosis with dual detection of nitric oxide and viscosity by a ratiometric fluorescent probe
Shaohui Han, Lei Yang, Miaomiao Liu, Haipu Li, Xiangzhi Song
Chemical Engineering Journal.2023; 463: 142383. CrossRef
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David Pérez-Boyero, Carlos Hernández-Pérez, Jorge Valero, Valeria Lorena Cabedo, José Ramón Alonso, David Díaz, Eduardo Weruaga
Frontiers in Cellular Neuroscience.2023;[Epub] CrossRef
Congenital diaphragmatic hernia increases the sensitivity of pulmonary arteries to nitric oxide
Alecsander F. Bressan, Victoria Oliveira Maia, Beatriz de Souza Rodrigues, Giuliana Bertozi, Sabrina S. Batah, Alexandre T. Fabro, Glória Pelizzo, Ugo Maria Pierucci, Rita C. Tostes, Lourenço Sbragia, Fernando S. Carneiro
Pharmacological Research.2023; 191: 106749. CrossRef
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Cells.2023; 12(9): 1297. CrossRef
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Jonhatan Contreras, Montserrat Alcázar-Valle, Eugenia Lugo-Cervantes, Diego A. Luna-Vital, Luis Mojica
Pharmaceuticals.2023; 16(6): 874. CrossRef
S-nitrosylation of EMMPRIN influences the migration of HSCs and MMP activity in liver fibrosis
Xinyan Zhu, Zihui Tang, Wei Li, Xiaojuan Li, Yasuko Iwakiri, Fei Liu
Acta Biochimica et Biophysica Sinica.2023; 55(10): 1640. CrossRef
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Gokhan Akcakavak, Filiz Kazak, Mehmet Zeki Yilmaz Deveci
Biology Bulletin.2023; 50(5): 987. CrossRef
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Journal of Hepatology.2023; 79(5): 1270. CrossRef
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Xinmiao Li, Feng Jiang, Yuhang Hu, Zhichao Lang, Yating Zhan, Rongrong Zhang, Qiqi Tao, Chengchu Luo, Jinglu Yu, Jianjian Zheng
Journal of Agricultural and Food Chemistry.2023;[Epub] CrossRef
Ameliorative role of inducible nitric oxide synthase inhibitors against sodium arsenite-induced renal and hepatic dysfunction in rats
Ashwani Kumar Sharma, Anmoldeep Kaur, Tajpreet Kaur, Sarabjit Kaur, Devendra Pathak, Amrit Pal Singh
Drug and Chemical Toxicology.2022; 45(5): 2255. CrossRef
G Protein-Coupled Receptor Kinase 2 as Novel Therapeutic Target in Fibrotic Diseases
Nan Li, Shan Shan, Xiu-Qin Li, Ting-Ting Chen, Meng Qi, Sheng-Nan Zhang, Zi-Ying Wang, Ling-Ling Zhang, Wei Wei, Wu-Yi Sun
Frontiers in Immunology.2022;[Epub] CrossRef
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Environmental Science and Pollution Research.2022; 29(22): 33774. CrossRef
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International Journal of Molecular Sciences.2022; 23(7): 4052. CrossRef
Inhibitory effect of water-soluble mulberry leaf extract on hepatic lipid accumulation in high-fat diet-fed rats via modulation of hepatic microRNA-221/222 expression and inflammation
Mak-Soon Lee, Cheamin Kim, Hyunmi Ko, Yangha Kim
Journal of Nutrition and Health.2022; 55(2): 227. CrossRef
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Jelena Marković Filipović, Marko Miler, Danijela Kojić, Jelena Karan, Ivana Ivelja, Jovana Čukuranović Kokoris, Milica Matavulj
International Journal of Molecular Sciences.2022; 23(11): 6062. CrossRef
Association of resveratrol with the suppression of TNF-α/NF-kB/iNOS/HIF-1α axis-mediated fibrosis and systemic hypertension in thioacetamide-induced liver injury
Hasnaa A. Ebrahim, Samaa S. Kamar, Mohamed A. Haidara, Noha S. Abdel Latif, Mohamed Abd Ellatif, Asmaa M. ShamsEldeen, Bahjat Al-Ani, Amal F. Dawood
Naunyn-Schmiedeberg's Archives of Pharmacology.2022; 395(9): 1087. CrossRef
Is Glyceryl Trinitrate, a Nitric Oxide Donor Responsible for Ameliorating the Chemical-Induced Tissue Injury In Vivo?
Ayesha Rahman Ahmed, Mahiba Ahmed, Senty Vun-Sang, Mohammad Iqbal
Molecules.2022; 27(14): 4362. CrossRef
Effect of nigella sativa oil on bisphenol a-induced hepatotoxicity in wistar albino rats: histopathological and biochemical investigation
Mehmet Burak ATEŞ, Durmuş HATİPOĞLU
International Journal of Agriculture Environment and Food Sciences.2022; 6(3): 402. CrossRef
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Renato Dantas-Medeiros, Allanny Alves Furtado, Ana C. Zanatta, Manoela Torres-Rêgo, Estela Mariana Guimarães Lourenço, Jovelina Samara Ferreira Alves, Éder Galinari, Hugo Alexandre de Oliveira Rocha, Gerlane Coelho Bernardo Guerra, Wagner Vilegas, Thiago
Journal of Ethnopharmacology.2021; 264: 113229. CrossRef
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Wolfgang Kreisel, Adhara Lazaro, Jonel Trebicka, Markus Grosse Perdekamp, Annette Schmitt-Graeff, Peter Deibert
International Journal of Molecular Sciences.2021; 22(19): 10372. CrossRef
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Khaled Z. Alawneh, Liqaa A. Raffee, Musa A. Alshehabat, Ahed Jumah Alkhatib
Veterinary World.2021; : 1804. CrossRef
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Van Quy Nguyen, Dong Gil You, Chan Ho Kim, Seunglee Kwon, Wooram Um, Byeong Hoon Oh, Jae Yoon An, Jueun Jeon, Jae Hyung Park
International Journal of Biological Macromolecules.2021; 192: 1231. CrossRef
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Cells.2021; 10(12): 3406. CrossRef
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Nitol Debnath, Farzana B. Rafique, Nasrin Akhter, Anayt Ulla, Tahmina Yasmin, Md Nurul Islam, Md A. Alam
Current Bioactive Compounds.2021; 17(4): 356. CrossRef
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Avinash Kumar, Rashmi Pathak, Henry A. Palfrey, Kirsten P. Stone, Thomas W. Gettys, Subramanyam N. Murthy
Nutrition & Metabolism.2020;[Epub] CrossRef
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Le Thi Thanh Thuy, Hoang Hai, Norifumi Kawada
Clinical and Molecular Hepatology.2020; 26(3): 280. CrossRef
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Mads Barloese, Mohammadnavid Chitgar, Jens Hannibal, Søren Møller
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Ye.V. Stetsuk, O.Ye. Akimov, K.V. Shepitko, N.V. Boruta, A.N. Goltsev
World of Medicine and Biology.2020; 16(73): 211. CrossRef
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M. Farmaha, M. Abrahamovych, O. Abrahamovych
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Erika Ramos-Tovar, Pablo Muriel
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Genta Kakiyama, Dalila Marques, Rebecca Martin, Hajime Takei, Daniel Rodriguez-Agudo, Sandra A. LaSalle, Taishi Hashiguchi, Xiaoying Liu, Richard Green, Sandra Erickson, Gregorio Gil, Michael Fuchs, Mitsuyoshi Suzuki, Tsuyoshi Murai, Hiroshi Nittono, Phil
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I-Chuan Yen, Jung-Chun Lin, Yu Chen, Qian-Wen Tu, Shih-Yu Lee
The American Journal of Chinese Medicine.2020; 48(08): 1859. CrossRef
Syntropic Lesions of the Cardiovascular System in Patients with Liver Cirrhosis: their Determination; Selected Pathogenetic Mechanisms; Characteristics and Specifics; Clinical Markers, Their Prognostic Value; Justification and Effectiveness of Modified Tr
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Lviv clinical bulletin.2020; 4(32): 8. CrossRef
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Moustafa Fathy, Esraa M.M.A. Khalifa, Michael Atef Fawzy
Life Sciences.2019; 216: 207. CrossRef
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Nature Reviews Gastroenterology & Hepatology.2019; 16(4): 221. CrossRef
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Rehab M. El-Sayed, Hebatalla I. Ahmed, Abd El-Lateef S. Abd El-Lateef, Azza A. Ali
Canadian Journal of Physiology and Pharmacology.2019; 97(5): 359. CrossRef
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Food & Function.2019; 10(10): 6351. CrossRef
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Mohamed Haloul, Edson R. A. Oliveira, Muhamuda Kader, Jakob Z. Wells, Tyler R. Tominello, Abdeljabar El Andaloussi, Cecelia C. Yates, Nahed Ismail
Scientific Reports.2019;[Epub] CrossRef
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Liver fibrosis, cirrhosis, and portal hypertension

The lymphatic vascular system in liver diseases: its role in ascites formation: Chuhan Chung, Yasuko Iwakiri; Clin Mol Hepatol 2013;19(2):99-104.
Published online June 27, 2013; DOI: https://doi.org/10.3350/cmh.2013.19.2.99

Abstract
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The lymphatic system is part of the circulatory system and plays a key role in normal vascular function. Its failure plays a crucial role in the development and maintenance of various diseases including liver diseases. Lymphangiogenesis (the growth of lymphatic vessels) and changes in the properties of lymphatic vessels are associated with pathogenesis of tumor metastases, ascites formation, liver fibrosis/cirrhosis and portal hypertension. Despite its significant role in liver diseases and its importance as a potential therapeutic target for those diseases, the lymphatic vascular system of the liver is poorly understood. Therefore, how the lymphatic vascular system in general and lymphangiogenesis in particular are mechanistically related to the pathogenesis and maintenance of liver diseases are largely unknown. This article summarizes: 1) the lymphatic vascular system; 2) its role in liver tumors, liver fibrosis/cirrhosis and portal hypertension; and 3) its role in ascites formation.

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ACG Case Reports Journal.2026;[Epub] CrossRef
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Journal of Cardiovascular Development and Disease.2025; 12(4): 124. CrossRef
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European Journal of Radiology.2025; 188: 112158. CrossRef
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Hepatology International.2025; 19(4): 720. CrossRef
Ascites – the Old, the Current, and the Future Ways of Management
Christine Pocha, Cristian Rios-Perez
Current Hepatology Reports.2025;[Epub] CrossRef
Portal hypertension contributes to ascites formation via the Piezo1−nuclear factor kappa-B−aquaporin1 pathway in liver cirrhosis
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Experimental & Molecular Medicine.2025; 57(10): 2305. CrossRef
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Gut Pathogens.2025;[Epub] CrossRef
Deep brain lymphatic vessels: a new player in brain functions, neurodegenerative diseases and psychiatric disorders
Bingqing Guo, Junzhuang Chang, Nashat Abumaria
Stress and Brain.2024; 4(1): 46. CrossRef
Serum proteomic profiling of patients with compensated advanced chronic liver disease with and without clinically significant portal hypertension
Frane Pastrovic, Rudjer Novak, Ivica Grgurevic, Stela Hrkac, Grgur Salai, Marko Zarak, Lovorka Grgurevic, Sona Frankova
PLOS ONE.2024; 19(4): e0301416. CrossRef
Lymphedema in a patient with decompensated cirrhosis
Elanaz Alizade, Muhsin Murat Harputluoğlu, Ali Alizade
Annals of Innovation in Medicine.2024;[Epub] CrossRef
Single-Center Experience With Dynamic Contrast-Enhanced Magnetic Resonance Lymphangiography for Diagnosing Lymphatic Disorders and Guiding Percutaneous Embolization
Yura Ahn, Hyun Jung Koo, Jooae Choe, Hee Ho Chu, Dong Hyun Yang, Joon-Won Kang, Ji Hoon Shin
Journal of Korean Medical Science.2024;[Epub] CrossRef
Lymphatic System Development and Function
Harish P. Janardhan, Brianna T. Wachter, Chinmay M. Trivedi
Current Cardiology Reports.2024; 26(11): 1209. CrossRef
Lymphangiogenesis in the liver of biliary atresia
Seitaro Kosaka, Toshihiro Muraji, Haruo Ohtani, Toshio Harumatsu, Sakika Shimizu, Miki Toma, Toshihiro Yanai, Satoshi Ieiri
BMC Gastroenterology.2024;[Epub] CrossRef
The ebb and flow of cardiac lymphatics: a tidal wave of new discoveries
Natalie R. Harris, László Bálint, Danielle M. Dy, Natalie R. Nielsen, Hernán G. Méndez, Amir Aghajanian, Kathleen M. Caron
Physiological Reviews.2023; 103(1): 391. CrossRef
Clinical anatomy of hepatic vessels by computed tomography angiography: A minireview
Aysegul Firat, Tugce Taskindere Abbasoglu, Musturay Karcaaltincaba, Yasemin H Balaban
World Journal of Radiology.2023; 15(1): 1. CrossRef
Fontan-associated liver disease: Diagnosis, surveillance, and management
Charlotte de Lange, Thomas Möller, Hanna Hebelka
Frontiers in Pediatrics.2023;[Epub] CrossRef
Lymphatics in the liver for translational science
Yasuko Iwakiri
Clinical Liver Disease.2023; 21(4): 122. CrossRef
Recombinant VEGF-C (Cys156Ser) improves mesenteric lymphatic drainage and gut immune surveillance in experimental cirrhosis
Pinky Juneja, Syed Nazrin Ruhina Rahman, Deepika Jakhar, Akash Kumar Mourya, Dinesh M. Tripathi, Impreet Kaur, Vaibhav Tiwari, Sumati Rohilla, Abhishek Gupta, Preety Rawal, Sukriti Baweja, Archana Rastogi, V.G.M. Naidu, Shiv K. Sarin, Subham Banerjee, Sav
JHEP Reports.2023; 5(10): 100816. CrossRef
Lymphatic vasculature in ovarian cancer
Sarit Pal, Sramana Bhowmick, Anurag Sharma, Jorge A. Sierra-Fonseca, Susmita Mondal, Favour Afolabi, Debarshi Roy
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2023; 1878(5): 188950. CrossRef
Oxidative Stress–Induced Liver Damage and Remodeling of the Liver Vasculature
Priyanka Banerjee, Niyanshi Gaddam, Vanessa Chandler, Sanjukta Chakraborty
The American Journal of Pathology.2023; 193(10): 1400. CrossRef
Lymphatic drainage dysfunction via narrowing of the lumen of cisterna chyli and thoracic duct after luminal dilation
Ryo Yano, Masashi Hirooka, Yohei Koizumi, Yoshiko Nakamura, Yusuke Imai, Makoto Morita, Yuki Okazaki, Takao Watanabe, Osamu Yoshida, Yoshio Tokumoto, Masanori Abe, Yoichi Hiasa
Hepatology International.2023; 17(6): 1557. CrossRef
An optimized visualization and quantitative protocol for in-depth evaluation of lymphatic vessel architecture in the liver
Jain Jeong, Masatake Tanaka, Yilin Yang, Nikolai Arefyev, Jenna DiRito, Gregory Tietjen, Xuchen Zhang, Matthew J. McConnell, Teruo Utsumi, Yasuko Iwakiri
American Journal of Physiology-Gastrointestinal and Liver Physiology.2023; 325(5): G379. CrossRef
Prevalence and risk factors of lymphatic dysfunction in cirrhosis patients with refractory ascites: An often unconsidered mechanism
Rahul Arya, Ramesh Kumar, Tarun Kumar, Sudhir Kumar, Utpal Anand, Rajeev Nayan Priyadarshi, Tanmoy Maji
World Journal of Hepatology.2023; 15(10): 1140. CrossRef
Hepatic lymphatic vascular system in health and disease
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Journal of Hepatology.2022; 77(1): 206. CrossRef
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European Journal of Cardio-Thoracic Surgery.2022;[Epub] CrossRef
Serial T2-Weighted Thoracic and Abdominal Lymphatic Imaging in Fontan Patients—New Insights into Dynamics of Lymphatic Abnormalities after Total Cavopulmonary Connection
Julia Moosmann, Christian Schroeder, Oliver Rompel, Ariawan Purbojo, Sven Dittrich
Journal of Cardiovascular Development and Disease.2022; 9(5): 138. CrossRef
Cisterna chyli as an optimal marker of tolvaptan response in severe cirrhotic ascites
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Scientific Reports.2022;[Epub] CrossRef
A Metabolomic Analysis of Cirrhotic Ascites
Diren Beyoğlu, Cedric Simillion, Federico Storni, Andrea De Gottardi, Jeffrey R. Idle
Molecules.2022; 27(12): 3935. CrossRef
Paneth Cells Regulate Lymphangiogenesis under Control of Microbial Signals during Experimental Portal Hypertension
Mohsin Hassan, Oriol Juanola, Irene Keller, Paolo Nanni, Witold Wolski, Sebastián Martínez-López, Esther Caparrós, Rubén Francés, Sheida Moghadamrad
Biomedicines.2022; 10(7): 1503. CrossRef
Oxidized low density lipoprotein in the liver causes decreased permeability of liver lymphatic- but not liver sinusoidal-endothelial cells via VEGFR-3 regulation of VE-Cadherin
Alyssa R. Goldberg, Megan Ferguson, Sarit Pal, Rachel Cohen, David J. Orlicky, Rebecca L. McCullough, Joseph M. Rutkowski, Matthew A. Burchill, Beth A. Jirón Tamburini
Frontiers in Physiology.2022;[Epub] CrossRef
Abdominal lymphatic system visibility, morphology, and abnormalities in children as seen on routine MCRP and its association with immune-mediated diseases
Ebtehaj AlShehri, Christopher Z. Lam, Binita M. Kamath, Govind B. Chavhan
European Radiology.2021; 31(1): 292. CrossRef
Potential of Liver T₁ Mapping for the Detection of Fontan-associated Liver Disease in Adults
Yumi Shiina, Kei Inai, Ryoko Ohashi, Michinobu Nagao
Magnetic Resonance in Medical Sciences.2021; 20(3): 295. CrossRef
Dieckol Decreases Caloric Intake and Attenuates Nonalcoholic Fatty Liver Disease and Hepatic Lymphatic Vessel Dysfunction in High-Fat-Diet-Fed Mice
Kyung-A Byun, Seyeon Oh, Myeongjoo Son, Chul-Hyun Park, Kuk Hui Son, Kyunghee Byun
Marine Drugs.2021; 19(9): 495. CrossRef
Lymphatic dysfunction in advanced cirrhosis: Contextual perspective and clinical implications
Ramesh Kumar, Utpal Anand, Rajeev Nayan Priyadarshi
World Journal of Hepatology.2021; 13(3): 300. CrossRef
Pathophysiology of the Lymphatic System in Patients With Heart Failure
Maxim Itkin, Stanley G. Rockson, Daniel Burkhoff
Journal of the American College of Cardiology.2021; 78(3): 278. CrossRef
The Relationship Between Lymphangiogenesis and Liver Regeneration After Partial Hepatectomy in Cholestatic Mice
Takashi Hamada, Masaaki Hidaka, Mitsuhisa Takatsuki, Yusuke Sakai, Haung Yu, Koji Natsuda, Shinichiro Ono, Tomohiko Adachi, Akihiko Soyama, Susumu Eguchi
Lymphatic Research and Biology.2020; 18(4): 322. CrossRef
The Role of Lymphatic Vascular Function in Metabolic Disorders
Pieter R. Norden, Tsutomu Kume
Frontiers in Physiology.2020;[Epub] CrossRef
Lymphatic targeting by albumin-hitchhiking: Applications and optimisation
Mohammad Abdallah, Olivia O. Müllertz, Ian K. Styles, Alexander Mörsdorf, John F. Quinn, Michael R. Whittaker, Natalie L. Trevaskis
Journal of Controlled Release.2020; 327: 117. CrossRef
The lymphatic system in alcohol-associated liver disease
Reiichiro Kondo, Yasuko Iwakiri
Clinical and Molecular Hepatology.2020; 26(4): 633. CrossRef
Liver lymphatic drainage patterns follow segmental anatomy in a murine model
Nicola C. Frenkel, Susanna Poghosyan, André Verheem, Timothy P. Padera, Inne H. M. Borel Rinkes, Onno Kranenburg, Jeroen Hagendoorn
Scientific Reports.2020;[Epub] CrossRef
Imaging the Lymphatic System in Fontan Patients
Floris E.A. Udink ten Cate, Eric T.T.L. Tjwa
Circulation: Cardiovascular Imaging.2019;[Epub] CrossRef
Non-contrast MR lymphography of the lymphatic system of the liver
Lionel Arrivé, Laurence Monnier-Cholley, Nora Cazzagon, Dominique Wendum, Edouard Chambenois, Sanaâ El Mouhadi
European Radiology.2019; 29(11): 5879. CrossRef
Fontan-associated liver disease: A review
Timothy T. Gordon-Walker, Kevin Bove, Gruschen Veldtman
Journal of Cardiology.2019; 74(3): 223. CrossRef
Chronic Liver Disease in Humans Causes Expansion and Differentiation of Liver Lymphatic Endothelial Cells
Beth A. Jiron Tamburini, Jeffrey M. Finlon, Austin E. Gillen, Michael S. Kriss, Kent A. Riemondy, Rui Fu, Ronald P. Schuyler, Jay R. Hesselberth, Hugo R. Rosen, Matthew A. Burchill
Frontiers in Immunology.2019;[Epub] CrossRef
The Role of Hepatic and Splanchnic Lymphatic System in Portal Hypertension and Ascites
Jordi Ribera, Bernat Córdoba-Jover, Irene Portolés, Manuel Morales-Ruiz
Current Hepatology Reports.2019; 18(2): 157. CrossRef
Nanoparticles' interactions with vasculature in diseases
Jie Kai Tee, Li Xian Yip, Eveline Sheau Tan, Supawan Santitewagun, Arun Prasath, Pu Chun Ke, Han Kiat Ho, David Tai Leong
Chemical Society Reviews.2019; 48(21): 5381. CrossRef
Metabolism in Acute-On-Chronic Liver Failure: The Solution More than the Problem
Maria-Angeles Aller, Natalia Arias, Javier Blanco-Rivero, Jaime Arias
Archives of Medical Research.2019; 50(5): 271. CrossRef
Gut Lymphangiopathy: Adding Fuel to the Fire in Chronic Liver Disease
Luis Tresierra, Maria-Angeles Aller, Isabel Prieto, Luis Santamaria, Jaime Arias
Advances in Bioscience and Biotechnology.2019; 10(10): 305. CrossRef
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Matthew McConnell, Yasuko Iwakiri
Hepatology International.2018; 12(S1): 11. CrossRef
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Maxim Itkin, Gregory J. Nadolski
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Emerging Concepts in Organ-Specific Lymphatic Vessels and Metabolic Regulation of Lymphatic Development
Brian W. Wong, Annalisa Zecchin, Melissa García-Caballero, Peter Carmeliet
Developmental Cell.2018; 45(3): 289. CrossRef
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Transplantation Direct.2017; 3(3): e138. CrossRef
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Sarah Mertlitz, Yu Shi, Martina Kalupa, Carsten Grötzinger, Jörg Mengwasser, Katarina Riesner, Steffen Cordes, Sefer Elezkurtaj, Olaf Penack
Blood.2017; 129(13): 1865. CrossRef
Periportal lymphatic system on post-hepatobiliary phase Gd-EOB-DTPA-enhanced MR imaging in normal subjects and patients with chronic hepatitis C
Yasunari Yamada, Shunro Matsumoto, Hiromu Mori, Ryo Takaji, Maki Kiyonaga, Naoki Hijiya, Rika Tanoue, Kenichiro Tomonari, Shuichi Tanoue, Norio Hongo, Masayuki Ohta, Masataka Seike, Masafumi Inomata, Kazunari Murakami, Masatsugu Moriyama
Abdominal Radiology.2017; 42(10): 2410. CrossRef
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Hepatology.2017; 65(6): 2132. CrossRef
Reply
Yasuko Iwakiri
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Anti-angiogenic and anti-lymphangiogenic role of praziquantel and artemether in experimental mansoniasis
Naglaa Fathy Abd El-Aal, Rania Said Hamza, Mona Magdy
Acta Parasitologica.2017;[Epub] CrossRef
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Disease Markers.2016; 2016: 1. CrossRef
Functional Immune Anatomy of the Liver—As an Allograft
A.J. Demetris, C.O.C. Bellamy, C.R. Gandhi, S. Prost, Y. Nakanuma, D.B. Stolz
American Journal of Transplantation.2016; 16(6): 1653. CrossRef
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Hepatology.2016; 64(3): 706. CrossRef
Anatomy of hepatic lymphatics and its implications in hepatic malignancies
Tuck Leong Yong, Nezor Houli, Chris Christophi
ANZ Journal of Surgery.2016; 86(11): 868. CrossRef
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Cellular and Molecular Gastroenterology and Hepatology.2016; 2(6): 733. CrossRef
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Katarína Vdoviaková, Katarína Vdoviaková, Eva Petrovová, Lenka Krešáková, Marcela Maloveská, Jana Teleky, Janka Jenčová, Jozef Živčák, Andrej Jenča Jr.
Medical Science Monitor.2016; 22: 4716. CrossRef
Avicenna (980-1037) on the Role of the Liver in Separating Fluid from the Blood, with Insight into the Process from E.H. Starling (1866-1907) a Millennium Later
Leon G. Fine
Nephron.2016; 133(2): 139. CrossRef
The value of systematic lymph node dissection for intrahepatic cholangiocarcinoma from the viewpoint of liver lymphatics
Yuji Morine, Mitsuo Shimada
Journal of Gastroenterology.2015; 50(9): 913. CrossRef
Nitric oxide in liver diseases
Yasuko Iwakiri, Moon Young Kim
Trends in Pharmacological Sciences.2015; 36(8): 524. CrossRef
Vascular pathobiology in chronic liver disease and cirrhosis – Current status and future directions
Yasuko Iwakiri, Vijay Shah, Don C. Rockey
Journal of Hepatology.2014; 61(4): 912. CrossRef
Pathophysiology of Portal Hypertension
Yasuko Iwakiri
Clinics in Liver Disease.2014; 18(2): 281. CrossRef
Formation of Fenestrae in Murine Liver Sinusoids Depends on Plasmalemma Vesicle-Associated Protein and Is Required for Lipoprotein Passage
Leonie Herrnberger, Robert Hennig, Werner Kremer, Claus Hellerbrand, Achim Goepferich, Hans Robert Kalbitzer, Ernst R. Tamm, Rafael Aldabe
PLoS ONE.2014; 9(12): e115005. CrossRef
Effects of Adenosine on Lymphangiogenesis
Bénédicte Lenoir, Daniel R. Wagner, Silvia Blacher, Graciela B. Sala-Newby, Andrew C. Newby, Agnès Noel, Yvan Devaux, Philippe Rouet
PLoS ONE.2014; 9(3): e92715. CrossRef
Update December 2013
Francine Blei
Lymphatic Research and Biology.2013; 11(4): 239. CrossRef