Clinical and Molecular Hepatology

"Vicnent Wai-Sun Wong"

Review

Liver fibrosis, cirrhosis, and portal hypertension

Personalized management of cirrhosis by non-invasive tests of liver fibrosis: Grace Lai-Hung Wong, Wendell Zaragoza Espinosa, Vicnent Wai-Sun Wong; Clin Mol Hepatol 2015;21(3):200-211.
Published online September 30, 2015; DOI: https://doi.org/10.3350/cmh.2015.21.3.200

Abstract
PDF

Owing to the high prevalence of various chronic liver diseases, cirrhosis is one of the leading causes of morbidity and mortality worldwide. In recent years, the development of non-invasive tests of fibrosis allows accurate diagnosis of cirrhosis and reduces the need for liver biopsy. In this review, we discuss the application of these non-invasive tests beyond the diagnosis of cirrhosis. In particular, their role in the selection of patients for hepatocellular carcinoma surveillance and varices screening is highlighted.

Citations

Citations to this article as recorded by

Performance of APRI and FIB-4 Scores Compared to FibroScan: A Cross-Sectional Study in a Black Sub-Saharan African Population
Jean-Bonny Nsumbu, Jean-Robert Makulo, Trésor Mutombo Tshiswaka, Christian Kisoka Lusunsi, Charles Nlombi Mbendi
Hepatic Medicine: Evidence and Research.2025; Volume 17: 27. CrossRef
Managing Ascites and Kidney Dysfunction in Decompensated Advanced Chronic Liver Disease: From “One Size Fits All” to a Multidisciplinary-Tailored Approach
Mario Romeo, Carmine Napolitano, Paolo Vaia, Fiammetta Di Nardo, Silvio Borrelli, Carlo Garofalo, Luca De Nicola, Alessandro Federico, Marcello Dallio
Livers.2025; 5(3): 46. CrossRef
Age and fibrosis index for the prediction of hepatocellular carcinoma risk in patients with high hepatitis B virus DNA but normal alanine aminotransferase
Gyeol Seong, Dong Hyun Sinn, Wonseok Kang, Geum-Youn Gwak, Moon Seok Choi, Joon Hyeok Lee, Kwang Cheol Koh, Seung Woon Paik, Yong-Han Paik
European Journal of Gastroenterology & Hepatology.2022; 34(1): 69. CrossRef
Retrospective Evaluation of Non-Invasive Assessment Based on Routine Laboratory Markers for Assessing Advanced Liver Fibrosis in Chronic Hepatitis B Patients
Zeyu Wang, Yonghe Zhou, Pengzhi Yu, Yonggang Liu, Mei Mei, Zhuo Bian, Wei Shao, Jinxia Lv, Xin Li, Wei Lu, Liang Xu
International Journal of General Medicine.2022; Volume 15: 5159. CrossRef
Addition of liver stiffness enhances the predictive accuracy of the PAGE‐B model for hepatitis B‐related hepatocellular carcinoma
Hye Yeon Chon, Han Ah Lee, Sang Jun Suh, Jung Il Lee, Byung Seok Kim, In Hee Kim, Chang Hyeong Lee, Byoung Kuk Jang, Hyun Woong Lee, Jae Seok Hwang, Chang Hun Lee, Jin‐Woo Lee, Jung Hwan Yu, Yeon Seok Seo, Hyung Joon Yim, Seung Up Kim
Alimentary Pharmacology & Therapeutics.2021; 53(8): 919. CrossRef
Risk assessment of hepatocellular carcinoma and liver‐related events using ultrasonography and transient elastography in patients with chronic hepatitis B
Sung Hwan Yoo, Tae Seop Lim, Hyun Woong Lee, Ja Kyung Kim, Jae Seung Lee, Hye Won Lee, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Jung Il Lee, Kwan Sik Lee, Seung Up Kim
Journal of Viral Hepatitis.2021; 28(10): 1362. CrossRef
Fibrosis-4, aspartate transaminase-to-platelet ratio index, and gamma-glutamyl transpeptidase-to-platelet ratio for risk assessment of hepatocellular carcinoma in chronic hepatitis B patients: comparison with liver biopsy
Mi Na Kim, Ju Ho Lee, Young Eun Chon, Yeonjung Ha, Seong Gyu Hwang
European Journal of Gastroenterology & Hepatology.2020; 32(3): 433. CrossRef
Liver Cirrhosis, Not Antiviral Therapy, Predicts Clinical Outcome in Cohorts with Heterogeneous Hepatitis B Viral Status
Mi Na Kim, Seong Gyu Hwang, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Kwang-Hyub Han, Seung Up Kim, Sang Hoon Ahn
Gut and Liver.2019; 13(2): 197. CrossRef
CLINICAL INTERPRETATION OF THE RESULTS OF FIBRO-, STEATOSCANNING OF THE LIVER IN CHRONIC HEPATITIS C
V. M. Tsyrkunov, E. N. Krotkova, A. A. Abdinasir, S. A. Chernyak
Hepatology and Gastroenterology.2019; 3(2): 156. CrossRef
Invasive and non-invasive assessment of portal hypertension
Jonathan Chung-Fai Leung, Thomson Chi-Wang Loong, James Pang, Jeremy Lok Wei, Vincent Wai-Sun Wong
Hepatology International.2018; 12(S1): 44. CrossRef
Non‐invasive tests for liver disease severity and the hepatocellular carcinoma risk in chronic hepatitis B patients with low‐level viremia
Namyoung Paik, Dong H. Sinn, Ji H. Lee, In S. Oh, Jung H. Kim, Wonseok Kang, Geum‐Youn Gwak, Yong‐Han Paik, Moon S. Choi, Joon H. Lee, Kwang C. Koh, Seung W. Paik
Liver International.2018; 38(1): 68. CrossRef
Management of chronic hepatitis B patients in immunetolerant phase: what latest guidelines recommend
Grace Lai-Hung Wong
Clinical and Molecular Hepatology.2018; 24(2): 108. CrossRef
Validation of the Baveno VI and the expanded Baveno VI criteria to identify patients who could avoid screening endoscopy
Joohwan Bae, Dong Hyun Sinn, Wonseok Kang, Geum‐Youn Gwak, Moon Seok Choi, Yong‐Han Paik, Joon Hyeok Lee, Kwang Cheol Koh, Seung Woon Paik
Liver International.2018; 38(8): 1442. CrossRef
Combination of Transient Elastography and an Enhanced Liver Fibrosis Test to Assess the Degree of Liver Fibrosis in Patients with Chronic Hepatitis B
Ja Yoon Heo, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Hyon-Suk Kim, Young Nyun Park, Kwang-Hyub Han, Kijun Song, Seung Up Kim
Gut and Liver.2018; 12(2): 190. CrossRef
Reduced risk of hepatocellular carcinoma by achieving a subcirrhotic liver stiffness through antiviral agents in hepatitis B virus‐related advanced fibrosis or cirrhosis
Byung Seok Kim, Yeon Seok Seo, Young Seok Kim, Chang Hyeong Lee, Han Ah Lee, Soon Ho Um, Jeong‐Ju Yoo, Sang Gyune Kim, Sang Jun Suh, Young Kul Jung, Sang Hoon Ahn, Kwang‐Hyub Han, Hyung Joon Yim, Seung Up Kim
Journal of Gastroenterology and Hepatology.2018; 33(2): 503. CrossRef
Magnetic resonance elastography of healthy livers at 3.0 T: Normal liver stiffness measured by SE-EPI and GRE
Jae Seok Bae, Jeong Min Lee, Sae-Jin Park, Kyung Bun Lee, Joon Koo Han
European Journal of Radiology.2018; 107: 46. CrossRef
Validation of modified fibrosis-4 index for predicting hepatocellular carcinoma in patients with compensated alcoholic liver cirrhosis
Ji Hyun Kim, Minjong Lee, Seung Woo Park, Myungho Kang, Minjeong Kim, Sang Hoon Lee, Tae Suk Kim, Jin Myung Park, Dae Hee Choi
Medicine.2018; 97(48): e13438. CrossRef
Subcirrhotic liver stiffness by FibroScan correlates with lower risk of hepatocellular carcinoma in patients with HBV-related cirrhosis
Mi Young Jeon, Hye Won Lee, Seung Up Kim, Ja Yoon Heo, Sojung Han, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Kwang-Hyub Han
Hepatology International.2017; 11(3): 268. CrossRef
2-dimensional shear wave elastography: Interobserver agreement and factors related to interobserver discrepancy
Kibo Yoon, Woo Kyoung Jeong, Yongsoo Kim, Min Yeong Kim, Tae Yeob Kim, Joo Hyun Sohn, Antoine Nordez
PLOS ONE.2017; 12(4): e0175747. CrossRef
Using transient elastography to predict hepatocellular carcinoma recurrence after radiofrequency ablation
Yu Rim Lee, Soo Young Park, Seung Up Kim, Se Young Jang, Won Young Tak, Young Oh Kweon, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Kwang‐Hyub Han, Keun Hur
Journal of Gastroenterology and Hepatology.2017; 32(5): 1079. CrossRef
Application of Ultrasound Elastography for Chronic Allograft Dysfunction in Kidney Transplantation
Zijie Wang, Haiwei Yang, Chuanjian Suo, Jifu Wei, Ruoyun Tan, Min Gu
Journal of Ultrasound in Medicine.2017; 36(9): 1759. CrossRef
Can Magnetic Resonance Elastography Fill a Niche in the Market for Noninvasive Assessment of Liver Fibrosis?
Seung Up Kim
Gut and Liver.2017; 11(3): 321. CrossRef
Transient Elastography is Superior to FIB-4 in Assessing the Risk of Hepatocellular Carcinoma in Patients With Chronic Hepatitis B
Seung Up Kim, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Kijun Song, Kwang-Hyub Han
Medicine.2016; 95(20): e3434. CrossRef
Liver resection for cancer: New developments in prediction, prevention and management of postresectional liver failure
Kim M.C. van Mierlo, Frank G. Schaap, Cornelis H.C. Dejong, Steven W.M. Olde Damink
Journal of Hepatology.2016; 65(6): 1217. CrossRef
How many times should we repeat measuring liver stiffness using shear wave elastography?: 5-repetition versus 10-repetition protocols
Seung Hee Choi, Woo Kyoung Jeong, Yongsoo Kim, Sanghyeok Lim, Jong Won Kwon, Tae Yeob Kim, Min Yeong Kim, Joo Hyun Sohn
Ultrasonics.2016; 72: 158. CrossRef
Association Between Level of Fibrosis, Rather Than Antiviral Regimen, and Outcomes of Patients With Chronic Hepatitis B
Hye Soo Kim, Beom Kyung Kim, Seung Up Kim, Jun Yong Park, Do Young Kim, Ki Jun Song, Jung Won Park, Yeong Jin Kim, Oidov Baatarkhuu, Kwang-Hyub Han, Sang Hoon Ahn
Clinical Gastroenterology and Hepatology.2016; 14(11): 1647. CrossRef
Prospective Comparison of Liver Stiffness Measurements between Two Point Shear Wave Elastography Methods: Virtual Touch Quantification and Elastography Point Quantification
Hyunsuk Yoo, Jeong Min Lee, Jeong Hee Yoon, Dong Ho Lee, Won Chang, Joon Koo Han
Korean Journal of Radiology.2016; 17(5): 750. CrossRef
Anesthesia for Patients with Concomitant Hepatic and Pulmonary Dysfunction
Geraldine C. Diaz, Michael F. O’Connor, John F. Renz
Anesthesiology Clinics.2016; 34(4): 797. CrossRef