Background/Aims Alcohol-associated liver disease (ALD) is a public health concern. ALD patients often have psychiatric comorbidities, but the effects of psychiatric interventions on ALD are not well-established. This study explores the prognostic impact of psychiatric intervention on ALD within UK Biobank cohort.
Methods This population-based study included 2,417 ALD patients from the UK Biobank cohort. Psychiatric intervention was defined by a consultation with psychiatrists during hospitalization or a history of medication related to alcohol use disorder and psychiatric comorbidities. Survival analysis was conducted, incorporating propensity score matching (PSM), to precisely assess the impact of psychiatric intervention.
Results Among 2,417 ALD patients, those with F10 (mental disorders due to alcohol) codes had poorer survival outcomes. Psychiatric intervention significantly improved the outcomes of both all-cause and liver-related mortality and reduced the incidence of liver cirrhosis. In subgroup or 2-year landmark analyses, psychiatric intervention consistently showed a survival benefit in ALD patients. In the multivariate analysis, psychiatric intervention was identified as a favorable prognostic factor (hazard ratio, 0.780; P=0.002 after PSM).
Conclusions This study demonstrates the favorable effect of psychiatric intervention in ALD patients with psychiatric comorbidities. These findings emphasize the importance of integrated management for ALD patients to address both their medical and psychiatric aspects. Therefore, we suggest the potential benefits of early psychiatric interventions in improving survival outcomes in ALD.
Citations
Citations to this article as recorded by
The urgent need for multidisciplinary approaches in managing alcohol-associated liver disease: Editorial on “The prognostic impact of psychiatric intervention on alcohol-associated liver disease: The UK Biobank cohort study” Soon Sun Kim, Jae Youn Cheong Clinical and Molecular Hepatology.2025; 31(1): 316. CrossRef
Trends in Concurrent Psychiatric Comorbidities in Alcohol-Associated Liver Disease: A Nationwide Study from 2015–2023 Shu-Yen Chan, Yee Hui Yeo, Hyunseok Kim, Molly Delk, Natchaya Polpichai, Pojsakorn Danpanichkul, Peng-Sheng Ting Digestive Diseases and Sciences.2025;[Epub] CrossRef
Hepatogastric fistula following a pyogenic liver abscess is extremely rare, and only a handful of cases have been reported. An 88-year-old female presented with generalized weakness, fever and chills. An abdominal computed tomography scan revealed a 5cm-sized hypodense lesion with internal septa in the left lateral section of the liver. Due to initial suspicion of early liver abscess, she was treated with empirical intravenous antibiotics. Initially, aspiration or drainage of the liver abscess was not performed due to immature lesion characteristics. An ultrasonography-guided percutaneous drainage of the liver abscess was performed 17 days after hospitalization due to a more mature lesion appearance on follow-up imaging. On tubography, contrast media leakage through the fistulous tract was visualized. Surgical management was performed, and she was discharged 2 weeks after surgery.
Citations
Citations to this article as recorded by
Hepatogastric Fistula as a Rare Complication of Pyogenic Liver Abscess: A Case Report Mohammad Kazem Amirbeigy, Amir Pasha Amel Shahbaz, Zahra Sekandari, Shahab Sheikhalishahi Clinical Case Reports.2025;[Epub] CrossRef
Hepatogastric fistula: A rare complication of liver abscess Sayan Malakar, Akash Mathur, Anshuman Elhence, Uday C. Ghoshal Indian Journal of Gastroenterology.2024; 43(4): 854. CrossRef
Double Trouble: Synchronous Hepatoduodenal and Hepatocolic Fistulisation in a Case of Untreated Liver Abscess Saket Dadhich, Vijay Vatvani, Hitakshi Chahal, Richa Jain, Hanuman R Khoja Cureus.2024;[Epub] CrossRef
Hepatogastric fistula: a complication of pyogenic liver abscess in a patient with the Brugarda syndrome – A rare case report Santosh Dev, Radheshyam Yadav, Birendra Sah, Ashok Kumar Sah, Bikal Ghimire, Jayant Kumar Shah Annals of Medicine & Surgery.2023; 85(6): 3098. CrossRef
A Population-Based Study of Unfavorable Prognostic Factors Associated With Pyogenic Liver Abscess Anna Bläckberg, Astrid Jönsson, Emma Svensson, Torgny Sunnerhagen, Ali Kiasat, Oskar Ljungquist Open Forum Infectious Diseases.2023;[Epub] CrossRef
Fix the Flat: Applying the Principles of Tire Aerosol Repair to Prevent Exsanguination From a Hemorrhagic Intrahepatic Mass Chase Tenewitz, Taylor S Harmon, Mika Matteo, Sanjay Lamsal, Jerry Matteo Cureus.2021;[Epub] CrossRef
Malignant hepatogastric fistula with associated secondary liver abscess: a rare complication of an occult gastric adenocarcinoma Alexander Mimery, Nicolas Ramly, Amitabha Das, Kheman Rajkomar BMJ Case Reports.2021; 14(8): e240238. CrossRef
A RARE CASE OF COMPLICATED LIVER ABSCESS WITH MIDDLE HEPATIC VEIN THROMBOSIS: A CASE REPORT AND REVIEW OF LITERATURE V.P.S. Punia, Praveen Raman Mishra, Shaavi Mittal, Akash Bharti, Prem Kumar, Mahek Lamba GLOBAL JOURNAL FOR RESEARCH ANALYSIS.2021; : 1. CrossRef
Gastric cancer and adenomatous colorectal polyp concomitant with pyogenic liver abscess and bacteremia Min Kyu Kang, Hee Jung Kwon, Min Cheol Kim Yeungnam University Journal of Medicine.2020; 37(3): 246. CrossRef
First
Prev
