Background/Aims The major histocompatibility class II (MHC II) transactivator, known as CIITA, is induced by Interferon gamma (IFN-γ) and plays a well-established role in regulating the expression of class II MHC molecules in antigen-presenting cells.
Methods Primary human hepatocytes (PHH) were isolated via therapeutic hepatectomy from two donors. The hepatocellular carcinoma (HCC) cell lines HepG2 and Huh7 were used for the mechanistic study, and HBV infection was performed in HepG2-NTCP cells. HBV DNA replication intermediates and secreted antigen levels were measured using Southern blotting and ELISA, respectively.
Result s: We identified a non-canonical function of CIITA in the inhibition of hepatitis B virus (HBV) replication in both HCC cells and patient-derived PHH. Notably, in vivo experiments demonstrated that HBV DNA and secreted antigen levels were significantly decreased in mice injected with the CIITA construct. Mechanistically, CIITA inhibited HBV transcription and replication by suppressing the activity of HBV-specific enhancers/promoters. Indeed, CIITA exerts antiviral activity in hepatocytes through ERK1/2-mediated down-regulation of the expression of hepatocyte nuclear factor 1α (HNF1α) and HNF4α, which are essential factors for virus replication. In addition, silencing of CIITA significantly abolished the IFN-γ-mediated anti-HBV activity, suggesting that CIITA mediates the anti-HBV activity of IFN-γ to some extent. HBV X protein (HBx) counteracts the antiviral activity of CIITA via direct binding and impairing its function.
Conclusions Our findings reveal a novel antiviral mechanism of CIITA that involves the modulation of the ERK pathway to restrict HBV transcription. Additionally, our results suggest the possibility of a new immune avoidance mechanism involving HBx.
Citations
Citations to this article as recorded by
Impact of VHSV on CIITA-mediated MHCII expression and antigen presentation in largemouth bass Xiaobing Lu, Ziling Qin, Zhe Hu, Hao Huang, Jie Su, Xiaoru Zhang, Meisheng Yi, Kuntong Jia Fish & Shellfish Immunology.2025; 162: 110336. CrossRef
Viral oncogenesis in cancer: from mechanisms to therapeutics Qing Xiao, Yi Liu, Tingting Li, Chaoyu Wang, Sanxiu He, Liuyue Zhai, Zailin Yang, Xiaomei Zhang, Yongzhong Wu, Yao Liu Signal Transduction and Targeted Therapy.2025;[Epub] CrossRef
Bioinformatics and system biology approach to discover the common pathogenetic processes between COVID-19 and chronic hepatitis B Xiao Ma, Tengda Huang, Yujia Song, Hongyuan Pan, Ao Du, Xinyi Zhou, Yong Zeng, Kefei Yuan, Xiaosheng Tan PLOS One.2025; 20(5): e0323708. CrossRef
Inflammation and immunity in liver homeostasis and disease: a nexus of hepatocytes, nonparenchymal cells and immune cells Enis Kostallari, Robert F. Schwabe, Adrien Guillot Cellular & Molecular Immunology.2025; 22(10): 1205. CrossRef
Gender-specific alteration of steroid metabolism and its impact on viral replication in a mouse model of hepatitis B virus infection Eun-Sook Park, Juhee Won, Sung Hyun Ahn, Ah Ram Lee, Donghyo Lee, Ju-Yeon Moon, Man Ho Choi, Kyun-Hwan Kim Animal Cells and Systems.2024; 28(1): 466. CrossRef
Class II transactivator restricts viral replication, extending its effect to HBV: Editorial on “Novel role of MHC class II transactivator in hepatitis B virus replication and viral counteraction” Cho-Rong Lee, Sung-Gyoo Park Clinical and Molecular Hepatology.2024; 30(4): 724. CrossRef
Chronic Hepatitis B Genotype C Mouse Model with Persistent Covalently Closed Circular DNA Deok-Hwa Seo, Wonhee Hur, Juhee Won, Ji-Won Han, Seung-Kew Yoon, Songmee Bae, Kyun-Hwan Kim, Pil-Soo Sung Viruses.2024; 16(12): 1890. CrossRef
Jong Man Kim, Deok Gie Kim, Jihyun Kim, Keunsung Lee, Kwang-Woong Lee, Je Ho Ryu, Bong-Wan Kim, Dong Lak Choi, Young Kyoung You, Dong-Sik Kim, Yang Won Nah, Koo Jeong Kang, Jai Young Cho, Geun Hong, Hee Chul Yu, Ju Ik Moon, Dongho Choi, Shin Hwang, Myoung Soo Kim
Clin Mol Hepatol 2021;27(3):451-462. Published online February 2, 2021
Background/Aims To analyze the incidence and risk factors of outcomes after liver transplantation (LT) in the Korean population.
Methods This study analyzed data from the liver cohort of Korean Organ Transplantation Registry (KOTRY) who had LT between May 2014 and December 2017. Study measures included the incidence of post-LT outcomes in recipients of living donor LT (LDLT) and deceased donor LT (DDLT). Cox multivariate proportional hazards model was used to determine the potential risk factors predicting the outcomes.
Result s: A total of 2,563 adult recipients with LT (LDLT, n=1,956; DDLT, n=607) were included, with mean±standard deviation age of 53.9±8.9 years, and 72.2% were male. The post-LT outcomes observed in each LDLT and DDLT recipients were death (4.0% and 14.7%), graft loss (5.0% and 16.1%), rejection (7.0% and 12.0%), renal failure (2.7% and 13.8%), new onset of diabetes (12.5% and 15.4%), and hepatocellular carcinoma (HCC) recurrence (both 6.7%). In both LDLT and DDLT recipients, the most common post-LT complications were renal dysfunction (33.6% and 51.4%), infection (26.7% and 48.4%), and surgical complication (22.5% and 23.9%). Incidence of these outcomes were generally higher among recipients of DDLT than LDLT. Multivariate analysis indicated recipient age and DDLT as significant risk factors associated with death and graft loss. DDLT and ABO incompatible transplant were prognostic factors for rejection, and HCC beyond Milan criteria at pre-transplant was a strong predictor of HCC recurrence.
Conclusions This study is a good indicator of the post-LT prognosis in the Korean population and suggests a significant burden of post-LT complications.
Citations
Citations to this article as recorded by
Outcomes of living-donor liver transplantation in older patients over 65 and 70 years compared to the younger recipients Deok-Gie Kim, Young Jin Yoo, Minyu Kang, Hwa-hee Koh, Eun-Ki Min, Jae Geun Lee, Myoung Soo Kim, Dong Jin Joo Asian Journal of Surgery.2026; 49(1): 76. CrossRef
Outcomes of Highly Urgent ABO-Incompatible Living Donor Liver Transplantation in National Databases Jongman Kim, Sang Jin Kim, Boram Park, Kyunga Kim, YoungRok Choi, Geun Hong, Jun Yong Park, Young Seok Han, Nam-Joon Yi, Seung Heui Hong, Soon-Young Kim, Jungbun Park, Youngwon Hwang, Dong-Hwan Jung Journal of Korean Medical Science.2026;[Epub] CrossRef
Temporal evolution of living donor liver transplantation survival—A United Network for Organ Sharing registry study Christian T.J. Magyar, Zhihao Li, Laia Aceituno, Marco P.A.W. Claasen, Tommy Ivanics, Woo Jin Choi, Luckshi Rajendran, Blayne A. Sayed, Roxana Bucur, Nadia Rukavina, Nazia Selzner, Anand Ghanekar, Mark Cattral, Gonzalo Sapisochin American Journal of Transplantation.2025; 25(2): 406. CrossRef
Impact of Chronic Hepatitis C Virus on Acute Kidney Injury After Living Donor Liver Transplantation Jae Hwan Kim, Kyoung-Sun Kim, Hye-Mee Kwon, Sung-Hoon Kim, In-Gu Jun, Jun-Gol Song, Gyu-Sam Hwang Anesthesia & Analgesia.2025; 141(3): 608. CrossRef
Preoperative Factors Affecting Graft Survival After ABO-incompatible Adult Liver Transplantation Hyun-Jun Nam, Deok-Gie Kim, Eun-Ki Min, Jae Geun Lee, Dai Hoon Han, Sinyoung Kim, Kyung-A Lee, Gi Hong Choi, Dong Jin Joo, Hyun Ok Kim, Soon Sung Kwon, Myoung Soo Kim Transplantation.2025; 109(3): e157. CrossRef
Association of primary hepatocellular carcinoma laterality with oncological outcomes for hepatic resection patients: A retrospective, multicenter, propensity score-matched study Okjoo Lee, Jaehong Jeong, So Kyung Yoon, Jun Chul Chung, Jongman Kim, Kwang-Woong Lee, Hyung Chul Kim Asian Journal of Surgery.2025; 48(4): 2241. CrossRef
Intrapatient variability of tacrolimus trough level may be not the cause, but an indirect parameter of comorbidities: Editorial on “Optimal tacrolimus levels for reducing CKD risk and the impact of intrapatient variability on CKD and ESRD development foll Jongman Kim Clinical and Molecular Hepatology.2025; 31(2): 589. CrossRef
Emergency living donor liver transplantation Jongman Kim Annals of Liver Transplantation.2025; 5(1): 27. CrossRef
Safety and Therapeutic Outcomes of Adjuvant Immunotherapy With Autologous Cytokine-induced Killer Cells for Patients With Hepatocellular Carcinoma Beyond Milan Criteria After Liver Transplantation Geun Hong, Dong Kyu Han, Jinsoo Rhu, Suk Kyun Hong, YoungRok Choi, Nam-Joon Yi, Kwang-Woong Lee, Jongman Kim, Jaeseok Yang, Kyung-Suk Suh Transplantation.2025; 109(10): e596. CrossRef
Meta‐Analysis: Comparison of Living Versus Deceased Liver Transplantation for Primary Sclerosing Cholangitis Ana Beatriz Afonso, Carolina Morais da Silva, Paulo Nogueira, Mariana Verdelho Machado Alimentary Pharmacology & Therapeutics.2025; 62(8): 768. CrossRef
Integrating Alpha‐Fetoprotein and Protein Induced by Vitamin K Antagonist‐II as Surveillance Tools After Liver Transplantation for Hepatocellular Carcinoma: A Novel Protocol for Early Detection of Tumor Recurrence Jiyoung Kim, Kwang‐Woong Lee, Jae‐Yoon Kim, Jaewon Lee, Hyun Hwa Choi, Su young Hong, Jeong‐Moo Lee, Suk Kyun Hong, YoungRok Choi, Nam‐Joon Yi, Kyung‐Suk Suh Clinical Transplantation.2025;[Epub] CrossRef
The evaluation of inflammatory and immune composite markers for complications after deceased donor liver transplantation – a retrospective cohort study Zhihong Zheng, Shuman Kuang, Zipei Wang, Jin Gu, Jichang Jiang, Zhou Yu, Lijin Zhao Annals of Medicine.2025;[Epub] CrossRef
Machine Learning–Based Selection of Resection vs Transplant and Survival in Hepatocellular Carcinoma Hyun Uk Kim, Ji Won Han, Pil Soo Sung, Jeong Won Jang, Seung Kew Yoon, Ho Joong Choi, Young Kyoung You JAMA Network Open.2025; 8(9): e2532353. CrossRef
Living versus deceased donor liver transplantation in highly urgent patients using Korean national data Jongman Kim, Sang Jin Kim, Kyunga Kim, YoungRok Choi, Geun Hong, Jun Yong Park, Young Seok Han, Nam-Joon Yi, Soon-Young Kim, Jung-Bun Park, Youngwon Hwang, Dong-Hwan Jung Annals of Liver Transplantation.2025; 5(2): 115. CrossRef
Predicting risk factors for waiting mortality in adult emergent living donor liver transplantation based on Korean national data Sang Jin Kim, Jongman Kim, Kyunga Kim, Soon-Young Kim, Jung-Bun Park, Youngwon Hwang, Dong-Hwan Jung Annals of Liver Transplantation.2025; 5(2): 107. CrossRef
Liver Transplantation for Hepatocellular Carcinoma: A Comprehensive Review Seok-Hwan Kim Convergence Hepatology.2025; 1(1): 24. CrossRef
Causes of death and associated factors with death after liver transplantation: a nationwide database study Junghyun Yoon, Hanjoon Kim, Dongho Choi, Boyoung Park HPB.2024; 26(1): 54. CrossRef
Clinical impact and risk factors for cytomegalovirus infection in deceased donor liver transplantation without prophylaxis: Single center experience Deok-Gie Kim, Eun-Ki Min, Jae Geun Lee, Dong Jin Joo, Myoung Soo Kim Annals of Liver Transplantation.2024; 4(1): 23. CrossRef
Recurrence risk prediction models for hepatocellular carcinoma after liver transplantation Xu Zhang, Chi Chen, Yan Wang, Jun Xu Journal of Gastroenterology and Hepatology.2024; 39(11): 2272. CrossRef
Chitinase-3 like-protein-1, a prognostic biomarker in patients with hepatocellular carcinoma and concomitant myosteatosis Chiyu He, Zhihang Hu, Zuyuan Lin, Hao Chen, Chenghao Cao, Jinyan Chen, Xudong Yang, Huigang Li, Wei Shen, Xuyong Wei, Li Zhuang, Shusen Zheng, Xiao Xu, Di Lu BMC Cancer.2024;[Epub] CrossRef
Mortality and associated factors among patients who underwent liver transplantation in South Korea from 2017 to 2021: a retrospective observational study Tak Kyu Oh, In-Ae Song Annals of Surgical Treatment and Research.2024; 107(5): 245. CrossRef
Effects of combined immunosuppressant and hepatitis B virus antiviral use on COVID-19 vaccination in recipients of living donor liver transplantation Ryunjin Lee, Jiwan Choi, Eunkyeong Lee, Jooyoung Lee, Jiye Kim, Seoon Kang, Hye-In An, Sung-Han Kim, Sung-Min Kim, Eun-Kyoung Jwa, Gil-Chun Park, Jung-Man Namgoong, Gi-Won Song, Young-In Yoon, Eunyoung Tak, Sung-Gyu Lee PeerJ.2024; 12: e18651. CrossRef
Post-operative recurrence of liver cancer according to antiviral therapy for detectable hepatitis B viremia: A nationwide study Byungyoon Yun, Sang Hoon Ahn, Juyeon Oh, Jin-Ha Yoon, Beom Kyung Kim European Journal of Internal Medicine.2023; 107: 66. CrossRef
Comparable Mortality Between Asian Patients with Chronic Hepatitis B Under Long-Term Antiviral Therapy vs Matched Control: A Population-Based Study Byungyoon Yun, Juyeon Oh, Sang Hoon Ahn, Jin-Ha Yoon, Beom Kyung Kim American Journal of Gastroenterology.2023; 118(6): 1001. CrossRef
Physical Performance Decline During the Early Posttransplantation Period Affects Survival After Living Donor Liver Transplantation Deok-Gie Kim, Shin Hwang, Kwang-Woong Lee, Gyu-seong Choi, Young Kyoung You, Je Ho Ryu, Bong-Wan Kim, Yang Won Nah, Dong-Sik Kim, Jai Young Cho, Koo Jeong Kang, Geun Hong, Hee Chul Yu, Man ki Ju, Suk-Won Suh, Kwan Woo Kim, Dongho Choi, Jaehong Jeong, Soo Transplantation.2023; 107(7): 1545. CrossRef
Validation of the Model for End-Stage Liver Disease 3.0 in Korean Patients on the Liver Transplant Waiting List Jiwon Yang, Jung-Bin Park, Ju Hyun Shim, Young-Suk Lim, Han Chu Lee, Jonggi Choi Clinical Gastroenterology and Hepatology.2023; 21(13): 3437. CrossRef
Incidence, mortality, and risk factors associated with carbapenem‐resistant Acinetobacter baumannii bacteremia within 30 days after liver transplantation Eun‐Ki Min, Seung Hyuk Yim, Mun Chae Choi, Jae Geun Lee, Dong Jin Joo, Myoung Soo Kim, Deok‐Gie Kim Clinical Transplantation.2023;[Epub] CrossRef
Risk Factors for Cytomegalovirus Infection and Its Impact on Survival after Living Donor Liver Transplantation in South Korea: A Nested Case-Control Study Seung Hyuk Yim, Mun Chae Choi, Deok-Gie Kim, Eun-Ki Min, Jae Geun Lee, Dong Jin Joo, Myoung Soo Kim Pathogens.2023; 12(4): 521. CrossRef
Impact of institutional case volume of solid organ transplantation on patient outcomes and implications for healthcare policy in Korea Christine Kang, Ho Geol Ryu Korean Journal of Transplantation.2023; 37(1): 1. CrossRef
Prediction model of hepatitis B virus-related hepatocellular carcinoma in patients receiving antiviral therapy Beom Kyung Kim, Sang Hoon Ahn Journal of the Formosan Medical Association.2023; 122(12): 1238. CrossRef
Living donor liver transplantation can address disparities in transplant access for patients with primary sclerosing cholangitis Fernanda Onofrio, Katina Zheng, Cherry Xu, Shiyi Chen, Wei Xu, Mary Vyas, Katie Bingham, Keyur Patel, Leslie Lilly, Mark Cattral, Nazia Selzner, Elmar Jaeckel, Cynthia Tsien, Aliya Gulamhusein, Gideon M. Hirschfield, Mamatha Bhat Hepatology Communications.2023;[Epub] CrossRef
Cancer Incidence in Living Liver Donors After Donor Hepatectomy Jongman Kim, Jae Heon Kim, Hyun Jung Kim Journal of Korean Medical Science.2023;[Epub] CrossRef
The Effect of Model for End-Stage Liver Disease 3.0 on Disparities between Patients with and without Hepatocellular Carcinoma in Korea Kunhee Kim, Deok-Gie Kim, Jae Geun Lee, Dong Jin Joo, Hye Won Lee Yonsei Medical Journal.2023; 64(11): 647. CrossRef
Pretransplant Functional Status Predicts Postoperative Morbidity and Mortality after Liver Transplantation in Patients with Cirrhosis Myung Ji Goh, Jihye Kim, Won Hyuk Chang, Dong Hyun Sinn, Geum-Yeon Gwak, Yong-Han Paik, Moon Seok Choi, Joon Hyeok Lee, Kwang Cheol Koh, Seung Woon Paik, Jong Man Kim, Wonseok Kang Gut and Liver.2023; 17(5): 786. CrossRef
Successful liver transplantation from a donor with occlusive portal vein thrombosis M. S. Novruzbekov, O. D. Olisov, V. A. Gulyaev, K. N. Lutsyk, B. I. Yaremin, B. I. Kazymov, K. M. Magomedov, A. R. Akhmedov, K. F. Alekberov Transplantologiya. The Russian Journal of Transplantation.2023; 15(3): 334. CrossRef
Evidence-based hyponatremia management in liver disease Ji Young Ryu, Seon Ha Baek, Sejoong Kim Clinical and Molecular Hepatology.2023; 29(4): 924. CrossRef
Association between the early high level of serum tacrolimus and recurrence of hepatocellular carcinoma in ABO-incompatible liver transplantation Ji Won Han, Jong Young Choi, Eun Sun Jung, Ji Hoon Kim, Hee Sun Cho, Jae-Sung Yoo, Pil Soo Sung, Jeong Won Jang, Seung Kew Yoon, Ho Joong Choi, Young Kyoung You World Journal of Gastrointestinal Surgery.2023; 15(12): 2727. CrossRef
Outcomes of living liver donors are worse than those of matched healthy controls Jin Yong Choi, Jae Heon Kim, Jong Man Kim, Hyun Jung Kim, Hyeong Sik Ahn, Jae-Won Joh Journal of Hepatology.2022; 76(3): 628. CrossRef
Changes in the Deceased-Donor Trend in Korea: Establishment of Regional Trauma Centers and KODA Jeong-Moo Lee Journal of Clinical Medicine.2022; 11(5): 1239. CrossRef
Healthy Spouses can be Considered as Living Liver Donors Okjoo Lee, Jong Man Kim, Sang Jin Kim, Jinsoo Rhu, Gyu‐Seong Choi, Jae‐Won Joh World Journal of Surgery.2022; 46(6): 1474. CrossRef
De Novo Intrahepatic Cholangiocarcinoma After Deceased Donor Liver Transplant in an Adult Patient Hyung Hwan Moon, Dong Hoon Shin, Young Il Choi Experimental and Clinical Transplantation.2022; 20(3): 316. CrossRef
Long-Term Outcomes of Laparoscopic Liver Resection for Centrally Located Hepatocellular Carcinoma Hyo Jun Kim, Jai Young Cho, Ho-Seong Han, Yoo-Seok Yoon, Hae Won Lee, Jun Suh Lee, Boram Lee, Yeongsoo Jo, Meeyouong Kang, Yeshong Park, Eunhye Lee Medicina.2022; 58(6): 737. CrossRef
Long-term Clinical Outcomes and Predictive Factors for Living-donor Liver Transplant Recipients With Biliary Strictures Ji Won Han, Jong Young Choi, Soon Kyu Lee, Pil Soo Sung, Jeong Won Jang, Seung Kew Yoon, Young Hoon Choi, In Seok Lee, Jung Suk Oh, Ho Jong Chun, Ho Joong Choi, Young Kyoung You Transplantation.2022; 106(10): 1990. CrossRef
Non-Renal Risk Factors for Chronic Kidney Disease in Liver Recipients with Functionally Intact Kidneys at 1 Month Deok-Gie Kim, Shin Hwang, Jong Man Kim, Je Ho Ryu, Young Kyoung You, Donglak Choi, Bong-Wan Kim, Dong-Sik Kim, Yang Won Nah, Tae-Seok Kim, Jai Young Cho, Geun Hong, Jae Do Yang, Jaryung Han, Suk-Won Suh, Kwan Woo Kim, Yun Kyung Jung, Ju Ik Moon, Jun Young Journal of Clinical Medicine.2022; 11(14): 4203. CrossRef
Evidence of nonsurgical treatment for polycystic liver disease Jeong-Ju Yoo, Hye In Jo, Eun-Ae Jung, Jae Seung Lee, Sang Gyune Kim, Young Seok Kim, Beom Kyung Kim Therapeutic Advances in Chronic Disease.2022;[Epub] CrossRef
Real‐world clinical features, health‐care utilization, and economic burden in decompensated cirrhosis patients: A national database Hankil Lee, Beom Kyung Kim Journal of Gastroenterology and Hepatology.2022; 37(11): 2154. CrossRef
Low-grade hepatocellular carcinoma characteristics, a practical nomogram and risk stratification system: a SEER population-based study Dashuai Yang, Yang Su, Fangrui Zhao, Yong Hu, Kailiang Zhao, Xiangyun Xiong, Mingqiang Zhu, Junpeng Pei, Youming Ding Expert Review of Gastroenterology & Hepatology.2022; 16(11-12): 1115. CrossRef
Low utilization of adult-to-adult LDLT in Western countries despite excellent outcomes: International multicenter analysis of the US, the UK, and Canada Tommy Ivanics, David Wallace, Marco P.A.W. Claasen, Madhukar S. Patel, Rushin Brahmbhatt, Chaya Shwaartz, Andreas Prachalias, Parthi Srinivasan, Wayel Jassem, Nigel Heaton, Mark S. Cattral, Nazia Selzner, Anand Ghanekar, Gabriela Morgenshtern, Neil Mehta, Journal of Hepatology.2022; 77(6): 1607. CrossRef
Prediction models of hepatocellular carcinoma recurrence after liver transplantation: A comprehensive review Sang Jin Kim, Jong Man Kim Clinical and Molecular Hepatology.2022; 28(4): 739. CrossRef
Development and Validation of a Difficulty Scoring System for Laparoscopic Liver Resection to Treat Hepatolithiasis Yeongsoo Jo, Jai Young Cho, Ho-Seong Han, Yoo-Seok Yoon, Hae Won Lee, Jun Suh Lee, Boram Lee, Eunhye Lee, Yeshong Park, MeeYoung Kang, Junghyun Lee Medicina.2022; 58(12): 1847. CrossRef
Suboptimal Performance of Hepatocellular Carcinoma Prediction Models in Patients with Hepatitis B Virus-Related Cirrhosis Jae Lee, Tae Lim, Hye Lee, Seung Kim, Jun Park, Do Kim, Sang Ahn, Hyun Lee, Jung Lee, Ja Kim, In Min, Beom Kim Diagnostics.2022; 13(1): 3. CrossRef
New Evidence of Oral Branched-Chain Amino Acid Supplementation on the Prognosis of Patients With Advanced Liver Disease Hankil Lee, Jeong-Ju Yoo, Sang Hoon Ahn, Beom Kyung Kim Clinical and Translational Gastroenterology.2022; 13(12): e00542. CrossRef
Extubation in the operating room results in fewer composite mechanical ventilation-related adverse outcomes in patients after liver transplantation: a retrospective cohort study Yan Xu, Yiding Zuo, Li Zhou, Xuechao Hao, Xiao Xiao, Mao Ye, Lulong Bo, Chunling Jiang, Jiayin Yang BMC Anesthesiology.2021;[Epub] CrossRef
Can hepatocellular carcinoma recurrence be prevented after liver transplantation? Jong Man Kim Clinical and Molecular Hepatology.2021; 27(4): 562. CrossRef
First
Prev
