Hepatitis B virus (HBV) remains a major cause of chronic liver diseases, especially in the Asia-Pacific region. In recent decades, coinfection with hepatitis C virus (HCV) and coexistence with metabolic dysfunction-associated steatotic liver disease (MASLD) have emerged as significant clinical concerns among HBV-infected subjects. Although global HBV vaccination programs and curative therapies for HCV have led to a marked decline in HBV/HCV coinfection, MASLD is rapidly becoming the predominant comorbidity due to the global surge in metabolic risk factors. HBV/HCV coinfection typically results in more severe liver damage, with unique challenges in antiviral treatment and risk of HBV reactivation post-HCV clearance. In contrast, HBV/MASLD overlap demonstrates complex metabolic-viral interactions that may influence viral replication, hepatitis B surface antigen seroclearance, fibrosis progression, and risk of hepatocellular carcinoma. This review critically compares the epidemiology, clinical outcomes, and management strategies of HBV patients with concurrent HCV or MASLD, while addressing current research gaps and proposing directions for future investigations.
Background/Aims The survival benefit of direct-acting antiviral (DAA) therapy for hepatitis C virus (HCV) infection in patients with hepatocellular carcinoma (HCC), particularly in Barcelona Clinic Liver Cancer (BCLC) stages B/C, remains largely uncertain. We aimed to explore the impact of DAA therapy on overall survival (OS) in HCC patients using a nationwide cohort study.
Methods We utilized the nationwide Taiwan Association for the Study of the Liver (TASL) HCV Registry (TACR) database to include all adults receiving a DAA therapy for HCV, excluding those with other viral infections, liver transplantation, non-HCC malignancies, and terminal-staged HCC. We respectively analyzed the adjusted odds ratio (aOR) for sustained virological response (SVR) and adjusted hazard ratio (aHR) for OS.
Result s: Between December 2013 and December 2020, 2,205 (9.3%) patients with HCC and 21,569 (90.7%) patients without HCC were include. The SVR rates were 96.6% in the HCC group and 98.8% in the non-HCC group (P<0.001), with HCC being an independent risk factor affecting SVR (aOR 0.41; 95% CI 0.31–0.54; P<0.001). In the whole patient cohort, SVR was independently associated with improved OS (aHR 0.46; 95% CI 0.35–0.60; P<0.001). Among patients with baseline HCC, SVR remained an independent factor related to OS (aHR 0.41; 95% CI 0.28–0.59; P<0.001). The impact of SVR on OS persisted significantly across BCLC stages 0/A and stages B/C.
Conclusions High SVR rates among HCC patients underscore the importance of DAA therapy in enhancing OS, reaffirming its efficacy across various HCC stages.
Citations
Citations to this article as recorded by
Revisiting unmet needs in clinical research on direct-acting antiviral therapy for HCC patients: Correspondence to letter to the editor on “Direct-acting antiviral therapy for patients with HCV-related hepatocellular carcinoma: A nationwide cohort study” Teng-Yu Lee, Pei-Chien Tsai, Shou-Wu Lee, Ming- Lung Yu Clinical and Molecular Hepatology.2026; 32(1): e99. CrossRef
Emerging evidence supports direct-acting antiviral therapy for HCC patients beyond the early stage: Correspondence to editorial on “Direct-acting antiviral therapy for patients with HCV-related hepatocellular carcinoma: A nationwide cohort study” Teng-Yu Lee, Pei-Chien Tsai, Shou-Wu Lee, Ming-Lung Yu Clinical and Molecular Hepatology.2026; 32(1): e68. CrossRef
Survival impact of hepatitis C virus eradication in patients with or without active hepatocellular carcinoma: A nationwide cohort study Teng-Yu Lee, Sheng-Shun Yang, Pei-Chien Tsai, Chung-Feng Huang, Chi-Yi Chen, Chao-Hung Hung, Chien-Hung Chen, Chi-Ming Tai, Pin-Nan Cheng, Hsing-Tao Kuo, Kuo-Chih Tseng, Lein-Ray Mo, Ching-Chu Lo, Yi-Hsiang Huang, Han-Chieh Lin, Pei-Lun Lee, Ming-Jong Bai European Journal of Cancer.2026; 232: 116109. CrossRef
Letter to the editor on “Direct-acting antiviral therapy for patients with HCV-related hepatocellular carcinoma: a nationwide cohort study” Qiong Wang, Zhongqing Qian, Xiaodi Yang, Deyan Chen, Xiaojing Wang, Fuliang Chen Clinical and Molecular Hepatology.2026; 32(1): e7. CrossRef
Setting the Record Straight: Utility and Outcomes in Patients With HCV Related HCC María Fernanda Guerra‐Veloz, Sital Shah, Beatrice Emmanouil, Mia Olsen, Renita George, Sarah Selemani, Paul J. Ross, Ivana Carey, Neha Mehta, Mark Gillyon‐Powell, Kosh Agarwal Journal of Viral Hepatitis.2026;[Epub] CrossRef
HIV, Viral Hepatitis, and Schistosomiasis Association with Liver Cancer: A Systematic Review Khumbuzile Canham, Pragalathan Naidoo, Sibusiso Senzani, Sayed Shakeel Kader, Zilungile L. Mkhize-Kwitshana Microorganisms.2025; 13(12): 2753. CrossRef
Background/Aims Chronic hepatitis C (CHC) patients who failed antiviral therapy are at increased risk for hepatocellular carcinoma (HCC). This study assessed the potential role of metformin and statins, medications for diabetes mellitus (DM) and hyperlipidemia (HLP), in reducing HCC risk among these patients.
Methods We included CHC patients from the T-COACH study who failed antiviral therapy. We tracked the onset of HCC 1.5 years post-therapy by linking to Taiwan’s cancer registry data from 2003 to 2019. We accounted for death and liver transplantation as competing risks and employed Gray’s cumulative incidence and Cox subdistribution hazards models to analyze HCC development.
Result s: Out of 2,779 patients, 480 (17.3%) developed HCC post-therapy. DM patients not using metformin had a 51% increased risk of HCC compared to non-DM patients, while HLP patients on statins had a 50% reduced risk compared to those without HLP. The 5-year HCC incidence was significantly higher for metformin non-users (16.5%) versus non-DM patients (11.3%; adjusted sub-distribution hazard ratio [aSHR]=1.51; P=0.007) and metformin users (3.1%; aSHR=1.59; P=0.022). Statin use in HLP patients correlated with a lower HCC risk (3.8%) compared to non-HLP patients (12.5%; aSHR=0.50; P<0.001). Notably, the increased HCC risk associated with non-use of metformin was primarily seen in non-cirrhotic patients, whereas statins decreased HCC risk in both cirrhotic and non-cirrhotic patients.
Conclusions Metformin and statins may have a chemopreventive effect against HCC in CHC patients who failed antiviral therapy. These results support the need for personalized preventive strategies in managing HCC risk.
Exploiting tumor lineage features for precision cancer therapy Lois M. Kelly, Nina Fenouille, Kris C. Wood, Alexandre Puissant Trends in Cancer.2026;[Epub] CrossRef
Prevention of liver cancer in the era of next-generation antivirals and obesity epidemic Hiroyuki Suzuki, Naoto Fujiwara, Amit G. Singal, Thomas F. Baumert, Raymond T. Chung, Takumi Kawaguchi, Yujin Hoshida Hepatology.2025;[Epub] CrossRef
Reply to the comment on “High-normal and abnormal alanine transaminase levels linked to increased risk of hepatoma following treatment for chronic hepatitis C” Yen-Chun Chen, Ming-Lung Yu Journal of the Formosan Medical Association.2025;[Epub] CrossRef
Beyond the Liver: A Comprehensive Review of Strategies to Prevent Hepatocellular Carcinoma Natchaya Polpichai, Sakditad Saowapa, Pojsakorn Danpanichkul, Shu-Yen Chan, Leandro Sierra, Johanna Blagoie, Chitchai Rattananukrom, Pimsiri Sripongpun, Apichat Kaewdech Journal of Clinical Medicine.2024; 13(22): 6770. CrossRef
Metabolic Dysfunction-Associated Steatotic Liver Disease in Chronic Hepatitis C Virus Infection: From Basics to Clinical and Nutritional Management Karina Gonzalez-Aldaco, Luis A. Torres-Reyes, Claudia Ojeda-Granados, Leonardo Leal-Mercado, Sonia Roman, Arturo Panduro Clinics and Practice.2024; 14(6): 2542. CrossRef
Diverting hepatic lipid fluxes with lifestyles revision and pharmacological interventions as a strategy to tackle steatotic liver disease (SLD) and hepatocellular carcinoma (HCC) Davide Misceo, Gabriele Mocciaro, Simona D’Amore, Michele Vacca Nutrition & Metabolism.2024;[Epub] CrossRef
Background/Aims Despite the high efficacy of direct-acting antivirals (DAAs), approximately 1–3% of hepatitis C virus (HCV) patients fail to achieve a sustained virological response. We conducted a nationwide study to investigate risk factors associated with DAA treatment failure. Machine-learning algorithms have been applied to discriminate subjects who may fail to respond to DAA therapy.
Methods We analyzed the Taiwan HCV Registry Program database to explore predictors of DAA failure in HCV patients. Fifty-five host and virological features were assessed using multivariate logistic regression, decision tree, random forest, eXtreme Gradient Boosting (XGBoost), and artificial neural network. The primary outcome was undetectable HCV RNA at 12 weeks after the end of treatment.
Result s: The training (n=23,955) and validation (n=10,346) datasets had similar baseline demographics, with an overall DAA failure rate of 1.6% (n=538). Multivariate logistic regression analysis revealed that liver cirrhosis, hepatocellular carcinoma, poor DAA adherence, and higher hemoglobin A1c were significantly associated with virological failure. XGBoost outperformed the other algorithms and logistic regression models, with an area under the receiver operating characteristic curve of 1.000 in the training dataset and 0.803 in the validation dataset. The top five predictors of treatment failure were HCV RNA, body mass index, α-fetoprotein, platelets, and FIB-4 index. The accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of the XGBoost model (cutoff value=0.5) were 99.5%, 69.7%, 99.9%, 97.4%, and 99.5%, respectively, for the entire dataset.
Conclusions Machine learning algorithms effectively provide risk stratification for DAA failure and additional information on the factors associated with DAA failure.
Citations
Citations to this article as recorded by
AI-Safe-C score: Assessing liver-related event risks in patients without cirrhosis after successful direct-acting antiviral treatment Huapeng Lin, Terry Cheuk-Fung Yip, Hye Won Lee, Xiangjun Meng, Jimmy Che-To Lai, Sang Hoon Ahn, Wenjing Pang, Grace Lai-Hung Wong, Lingfeng Zeng, Vincent Wai-Sun Wong, Victor de Lédinghen, Seung Up Kim Journal of Hepatology.2025; 82(3): 456. CrossRef
Real‐world efficacy and safety of universal 8‐week glecaprevir/pibrentasvir in patients with chronic hepatitis C with early chronic kidney disease or pre‐end‐stage renal disease: Insights from a nationwide hepatisis C virus registry in Taiwan Szu‐Jen Wang, Chung‐Feng Huang, Te‐Sheng Chang, Ching‐Chu Lo, Chao‐Hung Hung, Chien‐Wei Huang, Lee‐Won Chong, Pin‐Nan Cheng, Ming‐Lun Yeh, Cheng‐Yuan Peng, Chien‐Yu Cheng, Jee‐Fu Huang, Ming‐Jong Bair, Chih‐Lang Lin, Chi‐Chieh Yang, Hsing‐Tao Kuo, Tsai‐Yu The Kaohsiung Journal of Medical Sciences.2025;[Epub] CrossRef
Explainable machine learning for the assessment of donor grafts in liver transplantation Liang Zhixing, Ye Linsen, Jiang Peng, Dong Siyi, Yu Haoyuan, Li Kun, Li Siqi, Hu Yongwei, Zhang Mingshen, Liu Wei, Li Hua, Yi Shuhong, Chen Guihua, Xu Xiao, Zheng Shusen, Yang Yang Hepatology Research.2025; 55(6): 908. CrossRef
Role of risk factors and their variable types in predicting noise-induced hearing loss using artificial intelligence algorithms Zhengheng Zhang, Longteng Jiang, Meibian Zhang, Yuan Pan, Jinnan Zheng, Anqi Liu, Weijiang Hu, Xin Jin Hearing Research.2025; 465: 109353. CrossRef
Artificial Intelligence and Machine Learning Applications in Liver Disease Bhargav Vemulapalli, Meghana Ghattu, Kavya Atluri, James Lee, Vinod Rustgi Clinics in Liver Disease.2025; 29(4): 755. CrossRef
Unveiling the nexus between direct-acting antivirals in hepatitis C virus elimination and immune response Aya I. Abdelaziz, Eman Abdelsameea, Sara A. Wahdan, Doaa Elsherbiny, Zeinab Zakaria, Samar S. Azab Clinical and Experimental Medicine.2025;[Epub] CrossRef
Hepatitis C Virus: Epidemiological Challenges and Global Strategies for Elimination Daniela Toma, Lucreția Anghel, Diana Patraș, Anamaria Ciubară Viruses.2025; 17(8): 1069. CrossRef
Nationwide hepatitis C virus microelimination in uremic patients undergoing maintenance hemodialysis in Taiwan Chung-Feng Huang, Po-Cheng Liang, Yu-Ju Wei, Chao-Chun Wu, Shi-Lun Wei, Li-Ju Lin, Pei-Chun Hsieh, Tsui-Hsia Hsu, Maggie Shu-Mei Hsu, Ya-Xin Luo, Hsi-Chieh Chen, Tsu-Yun Ho, Shao-Hsuan Lin, Chia-Ling Liu, Kuo-Pen Cheng, John W. Ward, Ming-Lung Yu Journal of the Formosan Medical Association.2025; 124: S102. CrossRef
Identifying new strategies to combat cytomegalovirus by integrating existing and innovative approaches in diagnosis and treatment Nargiz Imamova, Ayten Feteliyeva, Adil M. Allahverdiyev Future Virology.2025; 20(10): 379. CrossRef
Artificial intelligence in hepatology: A comprehensive scoping review of clinical applications, challenges, and future directions Kirolos Eskandar iLIVER.2025; 4(4): 100205. CrossRef
Benefits of Hepatitis C Viral Eradication: A Real-World Nationwide Cohort Study in Taiwan Chin-Wei Chang, Wei-Fan Hsu, Kuo-Chih Tseng, Chi-Yi Chen, Pin-Nan Cheng, Chao-Hung Hung, Ching-Chu Lo, Ming-Jong Bair, Chien-Hung Chen, Pei-Lun Lee, Chun-Yen Lin, Hsing-Tao Kuo, Chun-Ting Chen, Chi-Chieh Yang, Jee-Fu Huang, Chi-Ming Tai, Jui-Ting Hu, Chih Digestive Diseases and Sciences.2024; 69(9): 3501. CrossRef
Bridging Real-World Data Gaps: Connecting Dots Across 10 Asian Countries Guilherme Silva Julian, Wen-Yi Shau, Hsu-Wen Chou, Sajita Setia JMIR Medical Informatics.2024; 12: e58548. CrossRef
The role of artificial intelligence in the management of liver diseases Ming‐Ying Lu, Wan‐Long Chuang, Ming‐Lung Yu The Kaohsiung Journal of Medical Sciences.2024; 40(11): 962. CrossRef
Real-World Experience, Effectiveness, and Safety of Direct-Acting Antivirals for the Treatment of Hepatitis C in Oman: A Cross-Sectional, Multicenter Study Khalid M. Al-Naamani, Heba Omar, Said A. Al Busafi, Halima H. Al Shuaili, Zakariya Al-Naamani, Murtadha Al-Khabori, Elias A. Said, Abdullah H. AlKalbani, B. R. Kamath, Bashar Emad, Shahina Daar, Lolo Alhajri, Alya AlKalbani, Zainab AlFarsi, Haifa Alzuhaib Journal of Clinical Medicine.2024; 13(23): 7411. CrossRef
Metabolic dysfunction-associated fatty liver disease (MAFLD) is an increasingly common liver disease worldwide. MAFLD is diagnosed based on the presence of steatosis on images, histological findings, or serum marker levels as well as the presence of at least one of the three metabolic features: overweight/obesity, type 2 diabetes mellitus, and metabolic risk factors. MAFLD is not only a liver disease but also a factor contributing to or related to cardiovascular diseases (CVD), which is the major etiology responsible for morbidity and mortality in patients with MAFLD. Hence, understanding the association between MAFLD and CVD, surveillance and risk stratification of MAFLD in patients with CVD, and assessment of the current status of MAFLD management are urgent requirements for both hepatologists and cardiologists. This Taiwan position statement reviews the literature and provides suggestions regarding the epidemiology, etiology, risk factors, risk stratification, nonpharmacological interventions, and potential drug treatments of MAFLD, focusing on its association with CVD.
Citations
Citations to this article as recorded by
FIB‐4 Serves as a Referral Index for Coronary Artery Calcification in Patients With MASLD Ya‐Chin Huang, Chih‐Wen Wang, Jiun‐Chi Huang, Po‐Cheng Liang, Ming‐Lun Yeh, Yi‐Yu Chen, Yi‐Hung Lin, Tyng‐Yuan Jang, Yu‐Ju Wei, Ming‐Yen Hsieh, Chao‐Kuan Huang, Hsu‐Han Chien, Chia‐Jen Wu, Jee‐Fu Huang, Chia‐Yen Dai, Wan‐Long Chuang, Chia‐I Lin, Chung‐Fen Journal of Gastroenterology and Hepatology.2026; 41(1): 332. CrossRef
Serum mir-181a as a potential serological biomarker for metabolic dysfunction-associated fatty liver disease: A cross sectional study Ke-Gong Xiong, Jin-Feng Kong, Tai-Shun Lin, Qing-Biao Lin, Kun-Yu Ke Medicine.2026; 105(4): e47290. CrossRef
A machine learning model to predict liver-related outcomes after the functional cure of chronic hepatitis B Moon Haeng Hur, Terry Cheuk-Fung Yip, Seung Up Kim, Hyun Woong Lee, Han Ah Lee, Hyung-Chul Lee, Grace Lai-Hung Wong, Vincent Wai-Sun Wong, Jun Yong Park, Sang Hoon Ahn, Beom Kyung Kim, Hwi Young Kim, Yeon Seok Seo, Hyunjae Shin, Jeayeon Park, Yunmi Ko, Yo Journal of Hepatology.2025; 82(2): 235. CrossRef
Reply to: “A machine learning model to predict liver-related outcomes after the functional cure of chronic hepatitis B: Is cirrhosis driving the performance?” Moon Haeng Hur, Jeong-Hoon Lee Journal of Hepatology.2025; 82(3): e143. CrossRef
Metabolic Dysfunction-Associated Steatotic Liver Disease is Associated with Increased Risks of Heart Failure Kai-Chun Chang, Tung-Hung Su, Cho-Kai Wu, Shang-Chin Huang, Tai-Chung Tseng, Chun-Ming Hong, Shih-Jer Hsu, Chen-Hua Liu, Hung-Chih Yang, Chun-Jen Liu, Jia-Horng Kao European Journal of Heart Failure.2025; 27(3): 512. CrossRef
Metabolic dysfunction-associated steatotic liver disease and its associated health risks Xia-Rong Liu, Szu-Ching Yin, Yi-Ting Chen, Mei-Hsuan Lee Journal of the Chinese Medical Association.2025; 88(5): 343. CrossRef
Fatty Liver and Hyperuricemia in Workers: Combined Effects on Metabolic Dysfunction and the Role of Lifestyle Factors Jui-Hua Huang, Ren-Hau Li, Hon-Ke Sia, Feng-Cheng Tang Metabolites.2025; 15(5): 318. CrossRef
Application of insulin resistance score in type 2 diabetes mellitus complicated with fatty liver and liver fibrosis Shaojie Duan, Mengdie Chen, Jie Chen, Yaojian Shao, Xiaolong Jin, Chaohui Wang, Ping Feng, Xiaosheng Teng, Zhenjun Yu European Journal of Gastroenterology & Hepatology.2025; 37(10): 1155. CrossRef
The role of Bergamot Polyphenolic Fraction (BPF) in MASLD-Induced HFpEF: Mitigate diastolic dysfunction by targeting chronic low-grade inflammation Cristina Carresi, Antonio Cardamone, Vincenzo Musolino, Rocco Mollace, Annamaria Tavernese, Anna Rita Coppoletta, Micaela Gliozzi, Vincenzo Mollace Biomedicine & Pharmacotherapy.2025; 190: 118375. CrossRef
Advanced Fibrosis and Cardiometabolic Risk Burden Increase Major Cardiovascular Events in Chronic Hepatitis C Patients With Steatotic Liver Disease After Viral Eradication Pei‐Chien Tsai, Chung‐Feng Huang, Ming‐Lun Yeh, Yu‐Ju Wei, Chih‐Wen Wang, Tyng‐Yuan Jang, Po‐Cheng Liang, Yi‐Hung Lin, Chia‐Yen Dai, Jee‐Fu Huang, Wan‐Long Chuang, Ming‐Lung Yu Alimentary Pharmacology & Therapeutics.2025;[Epub] CrossRef
Cardiovascular risk of tenofovir disoproxil fumarate or tenofovir alafenamide in patients with chronic hepatitis B: More questions than an answer Pin-Nan Cheng, Ming-Lung Yu Clinical and Molecular Hepatology.2024; 30(2): 144. CrossRef
MAFLD: from a disease framework to patient care Mohammed Eslam, Jacob George Hepatology International.2024; 18(S2): 823. CrossRef
Effect of metabolic dysfunction on the risk of liver-related events in patients cured of hepatitis C virus Wei-Fan Hsu American Journal of Cancer Research.2024; 14(4): 1914. CrossRef
The unfolded features on the synchronized fashion of gut microbiota and Drynaria rhizome against obesity via integrated pharmacology Ki-Kwang Oh, Sang-Jun Yoon, Seol Hee Song, Jeong Ha Park, Jeong Su Kim, Min Ju Kim, Dong Joon Kim, Ki-Tae Suk Food Chemistry.2024; 460: 140616. CrossRef
High sensitivity troponins and mortality in the population with metabolic dysfunction-associated steatotic liver disease Jingjing Hu, Yuteng Du, Yidan Zhou, Huiying Wang Scientific Reports.2024;[Epub] CrossRef
MASLD: an emerging factor in the pathophysiology and clinical management of ICC Zong-Long Li, Jia-Lu Chen, Yue Tang, De-Long Qin, Zhao-Hui Tang Hepatoma Research.2024;[Epub] CrossRef
Metabolic dysfunction-associated fatty liver disease: bridging cardiology and hepatology Xiao-Dong Zhou, Giovanni Targher, Christopher D. Byrne, Michael D. Shapiro, Li-Li Chen, Ming-Hua Zheng Cardiology Plus.2024; 9(4): 275. CrossRef
The prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) has increased among the general population and chronic hepatitis B (CHB) patients worldwide. Although fatty liver disease is a well-known risk factor for adverse liver outcomes like cirrhosis and hepatocellular carcinoma, its interactions with the hepatitis B virus (HBV) and clinical impacts seem complex. The presence of hepatic steatosis may suppress HBV viral activity, potentially leading to attenuated liver injury. In contrast, the associated co-morbidities like diabetes mellitus or obesity may increase the risk of developing adverse liver outcomes. These findings implicate that components of MAFLD may have diverse effects on the clinical manifestations of CHB. To this end, a clinical strategy is proposed for managing patients with concurrent CHB and MAFLD. This review article discusses the updated evidence regarding disease prevalence, interactions between steatosis and HBV, clinical impacts, and management strategies, aiming at optimizing holistic health care in the CHB population.
Citations
Citations to this article as recorded by
Metabolic health in antiviral era of chronic hepatitis B: Editorial on “Impacts of metabolic syndrome diseases on long-term outcomes of chronic hepatitis B patients treated with nucleos(t)ide analogues” Shang-Chin Huang, Jia-Horng Kao Clinical and Molecular Hepatology.2026; 32(1): 423. CrossRef
The impact of metabolic dysfunction-associated steatotic liver disease on the efficacy of pegylated interferon-based therapy in patients with chronic hepatitis B Jiaxin Han, Lianxin Xu, Yuqin Li, Ziling Wang, Minghui Zeng, Jieru Gao, Yuqiang Mi, Wentao Kuai, Huiling Xiang, Liang Xu Frontiers in Immunology.2026;[Epub] CrossRef
Association between fatty liver and risk of liver failure in patients with acute hepatitis B: a retrospective cohort study Xiao-hao Wang, Yu-nan Chang, Lu Zhang, Yan-li Yang, Lu-wen Liang, Yi Zeng, Zhi Zhou, Shan Zhong, Hu Li Frontiers in Cellular and Infection Microbiology.2026;[Epub] CrossRef
Viral hepatitis and liver disease in the Mongolian community in London ('MoLo'): A mixed methods study protocol to investigate the epidemiology and burden of disease to inform clinical and public health interventions Emily Martyn, Nara Dashdorj, Jessica Carter, Indrajit Ghosh, Enkh-Oyun Amarbayasgalan, Khadija Said Mohammed, Elizabeth Waddilove, Marion Delphin, Kathryn Jack, Camila Picchio, Joy Ko, Michelle Berkeley, Rubin Rose-Key, Eleni Nastouli, Sema Mandal, Monica Wellcome Open Research.2026; 11: 72. CrossRef
Pre-Existing and New-Onset Metabolic Dysfunctions Increase Cirrhosis and Its Complication Risks in Chronic Hepatitis B Shang-Chin Huang, Tung-Hung Su, Tai-Chung Tseng, Sih-Han Liao, Shih-Jer Hsu, Chun-Ming Hong, Ting-Yuan Lan, Chen-Hua Liu, Hung-Chih Yang, Chun-Jen Liu, Jia-Horng Kao American Journal of Gastroenterology.2025; 120(2): 401. CrossRef
Trajectories of hepatic steatosis and incidence of cardiovascular disease over a 29‐year follow‐up Ming‐Whei Yu, Wan‐Jung Wu, Chih‐Lin Lin, Chun‐Jen Liu, Wei‐Ya Peng, Pin‐Yu Huang, Yi‐Wen Huang, Jui‐Ting Hu, Hung‐Chuen Chang, Jyh‐Ming Liou Hepatology Research.2025; 55(1): 46. CrossRef
All-cause and cause-specific mortality in patients with chronic hepatitis B and concurrent steatotic liver disease Shang-Chin Huang, Tung-Hung Su, Tai-Chung Tseng, Shih-Jer Hsu, Chun-Ming Hong, Ting-Yuan Lan, Chen-Hua Liu, Hung-Chih Yang, Chun-Jen Liu, Jia-Horng Kao Journal of Hepatology.2025; 83(1): 43. CrossRef
Hepatitis B virus infection and metabolic dysfunction associated steatotic liver disease: Rising pandemic with complex interaction Ammara A Majeed, Amna S Butt World Journal of Hepatology.2025;[Epub] CrossRef
Impact of Metabolic Dysfunction-Associated Fatty/Steatotic Liver Disease on Hepatocellular Carcinoma Incidence and Long-Term Prognosis Post-Liver Resection: A Systematic Review and Meta-Analysis Qingyan Kong, Diao Kong, Bei Li, Wei Peng, Zheyu Chen Academic Radiology.2025; 32(11): 6514. CrossRef
Hepatocellular carcinoma surveillance after sustained virological response in chronic hepatitis C: Editorial on “Non-invasive prediction of post-sustained virological response hepatocellular carcinoma in hepatitis C virus: A systematic review and meta-ana Ho Soo Chun, Minjong Lee Clinical and Molecular Hepatology.2025; 31(1): 261. CrossRef
Inflammatory Indices and MAFLD Prevalence in Hypertensive Patients: A Large-Scale Cross-Sectional Analysis from China Di Shen, Xintian Cai, Junli Hu, Shuaiwei Song, Qing Zhu, Huimin Ma, Yingying Zhang, Rui Ma, Pan Zhou, Wenbo Yang, Jing Hong, Delian Zhang, Nanfang Li Journal of Inflammation Research.2025; Volume 18: 1623. CrossRef
Divergent roles of MASLD components in chronic hepatitis B: A double-edged sword Shang-Chin Huang, Tung-Hung Su Journal of Hepatology.2025; 83(1): e34. CrossRef
Association of concomitant MASLD and hepatitis B virus with clinical prognosis in hepatocellular carcinoma after curative resection Chih-Jan Ko American Journal of Cancer Research.2025; 15(2): 737. CrossRef
Mechanisms of hepatocellular carcinoma and cirrhosis development in concurrent steatotic liver disease and chronic hepatitis B Saisai Zhang, Lung-Yi Mak, Man-Fung Yuen, Wai-Kay Seto Clinical and Molecular Hepatology.2025; 31(Suppl): S182. CrossRef
SLC22A1 Resists Hepatitis B Virus by Activating the JAK/STAT Pathway and Predicts the Effect of Pegylated Interferon α–Based Therapy on Chronic Hepatitis B Huiying Yu, Bin Li, Huili Guo, Lin Li, Xiaoquan Liu, Lili Wu, Na Gao, Qiyi Zhao, Xiuqing Pang, Zhiliang Gao The Journal of Infectious Diseases.2025; 232(2): 474. CrossRef
Safety of tenofovir alafenamide in the context of hyperlipidemia and cardiovascular diseases: a nationwide analysis Jae-Young Kim, Hyuk Kim, Jeong-Ju Yoo, Sang Gyune Kim, Young-Seok Kim Hepatology International.2025; 19(4): 959. CrossRef
Non-invasive Assessment of Advanced Fibrosis and Steatosis in Chronic Hepatitis B Patients with Comorbid NAFLD Zhenhua Zhou, Feng Chen, Rongrong Zou, Qianhui Li, Xiaomin Xu Hepatitis Monthly.2025;[Epub] CrossRef
Study on Ultrasound-Assisted Diagnosis of CHB Complicated with NAFLD Hepatic Fibrosis Based on Deep Learning Xiuling Huang, Shan Huang, Changfeng Dong, Nuo Chen, Yuxuan Wang, Changmiao Wang, Yongquan Zhang, Cheng Feng Journal of Imaging Informatics in Medicine.2025; 38(6): 4349. CrossRef
Unraveling Demographic Patterns in Hepatitis B Clinical and Laboratory Profiles: Insights From a Ghanaian Cohort: A Retrospective Study Napoleon Bellua Sam, Saeed Folorunsho Majeed, Adams Dramani Health Science Reports.2025;[Epub] CrossRef
Molecular mechanisms of pyroptosis in non-alcoholic steatohepatitis and feasible diagnosis and treatment strategies Dong-fang Shang, Wen-qian Xu, Qing Zhao, Chen-lu Zhao, Si-ying Wang, Yong-li Han, He-guo Li, Ming-hao Liu, Wen-xia Zhao Pharmacological Research.2025; 216: 107754. CrossRef
Racing toward the future of chronic hepatitis B management: Achieving functional cure and enhancing hepatocellular carcinoma surveillance through precision medicine Yaru Shi, Rong Fan Interdisciplinary Medicine.2025;[Epub] CrossRef
The Associations of Serum Folate Forms with Metabolic Dysfunction-Associated Fatty Liver Disease and Liver Fibrosis: A Nationwide Cross-Sectional Study Hai Zhao, Wei Fan, Yan Yan, Yuxing Liu, Xuejun Kang Metabolites.2025; 15(6): 370. CrossRef
Managing Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD) in Primary Care Settings: A Review Vignesh Rajan, Ambarish Das, J. Venkatachalam, K. K. Lohani, Chandrakant Lahariya Preventive Medicine: Research & Reviews.2025; 2(4): 183. CrossRef
Hepatitis B virus promotes liver cancer by modulating the immune response to environmental carcinogens Mei Huang, Dongyao Wang, Jiao Huang, An-Na Bae, Yun Xia, Xutu Zhao, Mahsa Mortaja, Marjan Azin, Michael R. Collier, Yevgeniy R. Semenov, Jong Ho Park, Shadmehr Demehri Nature Communications.2025;[Epub] CrossRef
Unraveling the metabolic thread: Type 2 diabetes and fibrosis in chronic hepatitis B with steatosis Won-Mook Choi, Wai-Kay Seto Hepatology.2025;[Epub] CrossRef
Risk Factors of Metabolic Dysfunction-associated Steatotic Liver Disease in a Cohort of Patients With Chronic Hepatitis B Maria Kalafateli, Roberta Forlano, Eleanor Barnes, Laura Martinez-Gili, Madeleine Lacey, Giordano Sigon, Benjamin H. Mullish, Vincent Mallet, Lucia Parlati, Paul Richardson, Niamh Forde, Gaetano Serviddio, Rosanna Villani, Sabela Lens, Maria Buti, Elena V Clinical Gastroenterology and Hepatology.2025;[Epub] CrossRef
The Role of Chinese Medicine in the Treatment of Chronic Hepatitis B Shihao Zheng, Qiuyue Wang, Wenying Qi, Jinchi Xie, Xiaobin Zao, Xiaoke Li, Peng Zhang, Yongan Ye The American Journal of Chinese Medicine.2025; 53(05): 1285. CrossRef
Association between dietary inflammatory index and hepatic steatosis: cross-sectional evidence from the NHANES 2007–2020 Zhounan Wu, Yuhang Liang, Li Zeng, Jiayi Fang, Jinshen He Journal of Health, Population and Nutrition.2025;[Epub] CrossRef
Triglyceride-based lipotoxicity in the pathophysiology of chronic diseases Junjun Liu, Xiude Fan, Yongfeng Song, Jiajun Zhao Trends in Endocrinology & Metabolism.2025;[Epub] CrossRef
HBV and host metabolic crosstalk: Reprogramming pathways for viral replication and pathogenesis YanYing Yan, Zhiqiang Wei, Min Zheng, Mengji Lu, Xueyu Wang Virologica Sinica.2025; 40(5): 685. CrossRef
Predictive Value of Hepatic Steatosis for Postoperative Recurrence in Hepatitis B-Related Hepatocellular Carcinoma: Development of a Machine Learning-Based Prognostic Model Aoyun Hao, Changlei Li, Ruitao Sun, Bin Tan, Guanming Shao, Kun Li, Na Li, Weiyu Hu, Chao Qu, Jingyu Cao Journal of Hepatocellular Carcinoma.2025; Volume 12: 2459. CrossRef
Identification and Validation of Lipid Metabolism-Related Biomarkers GPD1 and CEBPD in Metabolic Dysfunction-Associated Steatohepatitis Jianyu Zhou, Chunying Xiao, Bin Huang, Fenfang Chen Journal of Inflammation Research.2025; Volume 18: 14805. CrossRef
Knowledge, attitudes, and practices toward fatty liver disease in patients with hepatitis B combined fatty liver disease Qian Li, Yongping Qiu, Lang Xiao, Lijian Ran, Hongli Deng, Xin Lu, Shilian Li, Yan Guo, Maolan Fu, Xuqing Zhang, Jie Xia, Huimin Liu Scientific Reports.2025;[Epub] CrossRef
CRISPR: a precise genome editing strategy for the treatment of hepatocellular carcinoma Subhrojyoti Mukherjee, Manish Kumar Expert Review of Anticancer Therapy.2025; : 1. CrossRef
Effects of Non-Alcoholic Fatty Liver Disease on Baseline Histology and 96-Week Entecavir Response in Treatment-Naïve Chronic Hepatitis B Xiaohui Gu, Weiguang Yang, Yue Hu, Yixin Li, Liwei Zheng, Bei Jiang Infection and Drug Resistance.2025; Volume 18: 6817. CrossRef
Association Between SGLT2 Inhibitor Use and Reduced Risk of Liver-Related Events, Including Hepatocellular Carcinoma, in Diabetic Patients with Viral Hepatitis: A Nationwide Cohort Study Seong Hee Kang, Jimi Choi, Hyung Joon Yim, Young Kul Jung, Sun Young Yim, Young-Sun Lee, Yeon Seok Seo, Ji Hoon Kim, Jong Eun Yeon, Kwan Soo Byun Cancers.2025; 18(1): 120. CrossRef
Usefulness of the Fibrosis‐4 index and alanine aminotransferase at 1 year of nucleos(t)ide analog treatment for prediction of hepatocellular carcinoma in chronic hepatitis B patients Jun Inoue, Takehiro Akahane, Tomoo Kobayashi, Osamu Kimura, Kosuke Sato, Masashi Ninomiya, Tomoaki Iwata, Satoshi Takai, Norihiro Kisara, Toshihiro Sato, Futoshi Nagasaki, Masahito Miura, Takuya Nakamura, Teruyuki Umetsu, Akitoshi Sano, Mio Tsuruoka, Masa Hepatology Research.2024; 54(2): 131. CrossRef
The interplay between chronic hepatitis B and diabetes mellitus: A narrative and concise review Shang‐Chin Huang, Jia‐Horng Kao The Kaohsiung Journal of Medical Sciences.2024; 40(1): 6. CrossRef
Metabolic Dysfunction-Associated Steatotic Liver Disease Facilitates Hepatitis B Surface Antigen Seroclearance and Seroconversion Shang-Chin Huang, Tung-Hung Su, Tai-Chung Tseng, Chi-Ling Chen, Shih-Jer Hsu, Chen-Hua Liu, Sih-Han Liao, Chun-Ming Hong, Ting-Yuan Lan, Hung-Chih Yang, Chun-Jen Liu, Pei-Jer Chen, Jia-Horng Kao Clinical Gastroenterology and Hepatology.2024; 22(3): 581. CrossRef
Low liver fat in non‐alcoholic steatohepatitis‐related significant fibrosis and cirrhosis is associated with hepatocellular carcinoma, decompensation and mortality Sung Won Lee, Daniel Q. Huang, Ricki Bettencourt, Veeral Ajmera, Monica Tincopa, Nabil Noureddin, Maral Amangurbanova, Harris Siddiqi, Egbert Madamba, Abdul M. Majzoub, Tarek Nayfeh, Nobuharu Tamaki, Namiki Izumi, Atsushi Nakajima, Masato Yoneda, Ramzan I Alimentary Pharmacology & Therapeutics.2024; 59(1): 80. CrossRef
Metabolic dysfunction associated steatotic liver disease in patients with plaque psoriasis: a case–control study and serological comparison Zheng Lin, Yue-yi Shi, Lu-yan Yu, Chen-xi Ma, Si-yi Pan, Yuan Dou, Qiu-jun Zhou, Yi Cao Frontiers in Medicine.2024;[Epub] CrossRef
The interplay of metabolic dysfunction‐associated fatty liver disease and viral hepatitis on liver disease severity: A large community‐based study in a viral endemic area Chung‐Feng Huang, Po‐Cheng Liang, Pei‐Chien Tsai, Yu‐Ju Wei, Ching‐I Huang, Chih‐Wen Wang, Tyng‐Yuan Jang, Ming‐Lun Yeh, Po‐Yao Hsu, Ming‐Yen Hsieh, Yi‐Hung Lin, Chia‐Yen Dai, Wan‐Long Chuang, Jee‐Fu Huang, Ming‐Lung Yu Journal of Gastroenterology and Hepatology.2024; 39(1): 193. CrossRef
High prevalence of fatty liver and its association with metabolic syndrome among rural adults with chronic hepatitis C: Implications for primary healthcare Ta-Jen Wang, Mei-Yen Chen, Yu-Chih Lin, Wen-Nan Chiu, Tung-Jung Huang, Hsu-Huei Weng BMC Public Health.2024;[Epub] CrossRef
Chronic Viral Hepatitis B and C Outweigh MASLD in the Associated Risk of Cirrhosis and HCC Mei-Hsuan Lee, Yi-Ting Chen, Yu-Han Huang, Sheng-Nan Lu, Tsai-Hsuan Yang, Jee-Fu Huang, Szu-Ching Yin, Ming-Lun Yeh, Chung-Feng Huang, Chia-Yen Dai, Wan-Long Chuang, Ming-Lung Yu, Hwai-I Yang, Hsuan-Yu Chen, Chien-Jen Chen Clinical Gastroenterology and Hepatology.2024; 22(6): 1275. CrossRef
Reply Shang-Chin Huang, Tung-Hung Su, Jia-Horng Kao Clinical Gastroenterology and Hepatology.2024; 22(9): 1957. CrossRef
Current perspectives of viral hepatitis Daisuke Usuda, Yuki Kaneoka, Rikuo Ono, Masashi Kato, Yuto Sugawara, Runa Shimizu, Tomotari Inami, Eri Nakajima, Shiho Tsuge, Riki Sakurai, Kenji Kawai, Shun Matsubara, Risa Tanaka, Makoto Suzuki, Shintaro Shimozawa, Yuta Hotchi, Ippei Osugi, Risa Katou, World Journal of Gastroenterology.2024; 30(18): 2402. CrossRef
Serum ApoB/ApoA1 ratio in patients with CHB and the occurrence of HBV related cirrhosis and HBV related hepatocellular carcinoma Xin Cai, Shi Peng, Xuan Xiao, Zhaoyang Huang, Pingan Zhang Scientific Reports.2024;[Epub] CrossRef
The overlap with metabolic dysfunction‐associated steatotic liver disease negatively affects outcomes of primary biliary cholangitis María Hernández‐Pérez, Daniel Riado, Eva Pena, Carmen Méndez, Fernando Pinedo, Paloma Ramos, Pilar Castillo, Miriam Romero, Conrado Fernández‐Rodríguez, Antonio Olveira Alimentary Pharmacology & Therapeutics.2024; 60(5): 613. CrossRef
Hepatitis B surface antigen loss in chronic hepatitis B patients with low‐viral‐load Tyng‐Yuan Jang, Batbold Batsaikhan, Yo‐Chia Chen, Chia‐Yen Dai Journal of Gastroenterology and Hepatology.2024; 39(11): 2327. CrossRef
Response to the letter of HEPI-D-24–00252 Shang-Chin Huang, Tung-Hung Su, Jia-Horng Kao Hepatology International.2024; 18(4): 1340. CrossRef
Functional cure of chronic hepatitis B encounters resmetirom Nai-Bin Yang, Wai-Kay Seto, Ming-Hua Zheng Clinical and Molecular Hepatology.2024; 30(3): 580. CrossRef
Hepatic macrophage niche: a bridge between HBV-mediated metabolic changes with intrahepatic inflammation Jun Wang, Hongzhou Lu, Qian Li Frontiers in Immunology.2024;[Epub] CrossRef
Outcome of bariatric surgery in patients with unexpected liver cirrhosis: A multicenter study from China Xia Sun, Libin Yao, Xing Kang, Weihua Yu, Fidele Kakule Kitaghenda, Mohammad Sajjad Ibn Rashid, Angeline Nogue Taguemkam, Jian Hong, Zhiyong Dong, Xitai Sun, Xiaocheng Zhu Liver Research.2024; 8(3): 172. CrossRef
Disease modifiers and novel markers in hepatitis B virus-related hepatocellular carcinoma Lung-Yi Mak Journal of Liver Cancer.2024; 24(2): 145. CrossRef
Comparison of Non-invasive Biochemical Fibrosis Markers According to Obesity-Based Metabolic Profile in Chronic Liver Disease with Chronic Hepatitis B Etiology Sedat Çiftel Ağrı Tıp Fakültesi Dergisi.2024; 2(3): 113. CrossRef
Effect of dyslipidemia on HBsAg clearance in nucleos(t)ide analogues-experienced chronic hepatitis B patients treated with peginterferon alfa Kaimin Song, Lan Ren, Yunyun Qian, Huitong Wang, Zhixiang Guo, Huatang Zhang, Yijie Lin, Yijuan Zheng, Dawu Zeng, Yongjun Zhou, Zhijun Su, Xueping Yu BMC Infectious Diseases.2024;[Epub] CrossRef
Effect of tenofovir versus entecavir on the long-term prognosis in hepatocellular carcinoma patients with concurrent metabolic dysfunction-associated steatotic liver disease and hepatitis B Qingyan Kong, Qianqian Gao, Wenjie Li, Zheyu Chen Asian Journal of Surgery.2024; 47(11): 4725. CrossRef
Retrospective cohort evaluation study in terms of cardiovascular and metabolic diseases in chronic hepatitis B patients Aysun Yakut Frontiers in Endocrinology.2024;[Epub] CrossRef
An insight into the updated pharmacotherapy of metabolic-associated fatty liver disease (MAFLD) or metabolic dysfunction-associated steatohepatitis (MASH) in lean individuals: a review Sanjay Bandyopadhyay, Shambo Samrat Samajdar, Sirshendu Chaudhuri, Saibal Das Hospital Practice.2024; 52(4-5): 123. CrossRef
Impact of concurrent MASLD on early-stage HCC following curative resection in chronic hepatitis B Cao-Ngoc Huynh American Journal of Cancer Research.2024; 14(9): 4567. CrossRef
Obesity and risk for liver disease: a two-sample Mendelian randomisation study Wen An, Jing Luo, Zhe Yu, Mengqi Li, Herui Wei, Aqian Song, Yuanpeng Mao, Hao Bian, Lingling He, Fan Xiao, Hongshan Wei British Journal of Nutrition.2024; 132(10): 1403. CrossRef
Comparison of lipid profile alterations in chronic hepatitis b patients receiving tenofovir alafenamide or tenofovir disoproxil fumarate Shenglong Lin, Wanlong Huang, Ziyuan Liao, Huaxi Ma, Wenjun Wu, Minghua Lin, Defu Huang, Haibing Gao Scientific Reports.2024;[Epub] CrossRef
Revolutionizing the understanding of liver disease: Metabolism, function and future Arnulfo E Morales-Galicia, Mariana M Ramírez-Mejía, Guadalupe Ponciano-Rodriguez, Nahum Méndez-Sánchez World Journal of Hepatology.2024; 16(12): 1365. CrossRef
Changing the nomenclature from nonalcoholic fatty liver disease to metabolic dysfunction-associated fatty liver disease is more than a change in terminology Eileen Laurel Yoon, Dae Won Jun Clinical and Molecular Hepatology.2023; 29(2): 371. CrossRef
Distinct effects of hepatic steatosis and metabolic dysfunction on the risk of hepatocellular carcinoma in chronic hepatitis B Shang-Chin Huang, Tung-Hung Su, Tai-Chung Tseng, Chi-Ling Chen, Shih-Jer Hsu, Sih-Han Liao, Chun-Ming Hong, Chen-Hua Liu, Ting-Yuan Lan, Hung-Chih Yang, Chun-Jen Liu, Pei-Jer Chen, Jia-Horng Kao Hepatology International.2023; 17(5): 1139. CrossRef
Reply to: ‘A risk prediction model for hepatocellular carcinoma after hepatitis B surface antigen seroclearance: Has the correct patient cohort been targeted?’ Hyun Yang, Ji Hoon Kim, Ji Won Han, Soon Kyu Lee, Jeong Won Jang Journal of Hepatology.2023; 79(4): e155. CrossRef
Diabetic MAFLD is associated with increased risk of hepatocellular carcinoma and mortality in chronic viral hepatitis patients Mi Na Kim, Kyungdo Han, Juhwan Yoo, Seong Gyu Hwang, Xuehong Zhang, Sang Hoon Ahn International Journal of Cancer.2023; 153(8): 1448. CrossRef
Hepatocellular carcinoma (HCC) is the fourth most common cancer and the second leading cause of cancer-related death in Taiwan. The Taiwan Liver Cancer Association and the Gastroenterological Society of Taiwan developed and updated the guidelines for HCC management in 2020. In clinical practice, we follow these guidelines and the reimbursement policy of the government. In Taiwan, abdominal ultrasonography, alpha-fetoprotein, and protein induced by vitamin K absence or antagonist-II (PIVKA-II) tests are performed for HCC surveillance every 6 months or every 3 months for high-risk patients. Dynamic computed tomography, magnetic resonance imaging, and contrast-enhanced ultrasound have been recommended for HCC surveillance in extremely high-risk patients or those with poor ultrasonographic visualization results. HCC is usually diagnosed through dynamic imaging, and pathological diagnosis is recommended. Staging of HCC is based on a modified version of the Barcelona Clinic Liver Cancer (BCLC) system, and the HCC management guidelines in Taiwan actively promote curative treatments including surgery and locoregional therapy for BCLC stage B or C patients. Transarterial chemoembolization (TACE), drug-eluting bead TACE, transarterial radioembolization, and hepatic artery infusion chemotherapy may be administered for patients with BCLC stage B or C HCC. Sorafenib and lenvatinib are reimbursed as systemic therapies, and regorafenib and ramucirumab may be reimbursed in cases of sorafenib failure. First-line atezolizumab with bevacizumab is not yet reimbursed but may be administered in clinical practice. Systemic therapy and external beam radiation therapy may be used in specific patients. Early switching to systemic therapy in TACE-refractory patients is a recent paradigm shift in HCC management.
Citations
Citations to this article as recorded by
Emerging evidence supports direct-acting antiviral therapy for HCC patients beyond the early stage: Correspondence to editorial on “Direct-acting antiviral therapy for patients with HCV-related hepatocellular carcinoma: A nationwide cohort study” Teng-Yu Lee, Pei-Chien Tsai, Shou-Wu Lee, Ming-Lung Yu Clinical and Molecular Hepatology.2026; 32(1): e68. CrossRef
Survival impact of hepatitis C virus eradication in patients with or without active hepatocellular carcinoma: A nationwide cohort study Teng-Yu Lee, Sheng-Shun Yang, Pei-Chien Tsai, Chung-Feng Huang, Chi-Yi Chen, Chao-Hung Hung, Chien-Hung Chen, Chi-Ming Tai, Pin-Nan Cheng, Hsing-Tao Kuo, Kuo-Chih Tseng, Lein-Ray Mo, Ching-Chu Lo, Yi-Hsiang Huang, Han-Chieh Lin, Pei-Lun Lee, Ming-Jong Bai European Journal of Cancer.2026; 232: 116109. CrossRef
HCC predictors in routine practice for patients with chronic liver diseases: Correspondence to editorial on “High SAFE scores predict hepatocellular carcinoma in viral and non-viral hepatitis and metabolic dysfunction associated steatotic liver disease” Tung-Hung Su, Jia-Horng Kao Clinical and Molecular Hepatology.2026; 32(1): e52. CrossRef
Transarterial chemoembolization combined with immune checkpoint inhibitors and anti-VEGF agents for intermediate HCC: a multicenter study Wei-Yi Jiang, Jin-Kai Feng, Bin Zhou, Si-Si Ren, Yu-Chao Hou, Fang-Fang Zhang, Yan-Jun Xiang, Zong-Han Liu, Rong-Chen Chen, Yun-Feng Shan, Chao Liang, Hong-Kun Zhou, Lin Gong, Shu-Qun Cheng European Journal of Surgical Oncology.2026; 52(3): 111407. CrossRef
Distinct tumor immune microenvironment modulation by anti-PD-1/PD-L1, VEGF, and CTLA-4 blockade provides a rationale for triplet therapy in hepatocellular carcinoma Hideki Iwamoto, Hironori Koga, Takumi Kawaguchi Clinical and Molecular Hepatology.2026; 32(1): e38. CrossRef
Mac-2 binding protein glycosylation isomer as a novel serum biomarker for recurrence in hepatocellular carcinoma Kyle R Stephens, Megan Wilson, Manting Xu, Jeremy T Gaskins, Gina Genova, Robert C G Martin II World Journal of Gastroenterology.2026;[Epub] CrossRef
Outcomes of radiofrequency ablation for hepatocellular carcinoma with concurrent steatotic liver disease Feng‐Pai Tsai, Tung‐Hung Su, Shang‐Chin Huang, Tai‐Chung Tseng, Shih‐Jer Hsu, Sih‐Han Liao, Chun‐Ming Hong, Chen‐Hua Liu, Hung‐Chih Yang, Chun‐Jen Liu, Pei‐Jer Chen, Jia‐Horng Kao Cancer.2025;[Epub] CrossRef
Pre-Existing and New-Onset Metabolic Dysfunctions Increase Cirrhosis and Its Complication Risks in Chronic Hepatitis B Shang-Chin Huang, Tung-Hung Su, Tai-Chung Tseng, Sih-Han Liao, Shih-Jer Hsu, Chun-Ming Hong, Ting-Yuan Lan, Chen-Hua Liu, Hung-Chih Yang, Chun-Jen Liu, Jia-Horng Kao American Journal of Gastroenterology.2025; 120(2): 401. CrossRef
Editorial: PIVKA‐II Facilitates Risk Stratification for HCC Following HCV Cure Tung‐Hung Su, Wei‐Chih Liao Alimentary Pharmacology & Therapeutics.2025; 61(3): 583. CrossRef
Precision surgery for hepatocellular carcinoma Christian Tibor Josef Magyar, Luckshi Rajendran, Zhihao Li, Vanessa Banz, Arndt Vogel, Grainne Mary O'Kane, Albert Chi-Yan Chan, Gonzalo Sapisochin The Lancet Gastroenterology & Hepatology.2025; 10(4): 350. CrossRef
Dynamic prognostication and treatment planning for hepatocellular carcinoma: A machine learning-enhanced survival study using multi-centric data Lujun Shen, Yiquan Jiang, Linbin Lu, Mengxuan Cui, Jiming Xu, Chen Li, Ruizhi Tang, Qi Zeng, Kai Li, Juan Nie, Jingjun Huang, Boyang Chang, Nan Wu, Feng Shi, Ge Ren, Yao Wang, Zhimei Huang, Chao An, Zhongguo Zhou, Chaofeng Li, Xiong Chen, Letao Lin, Peiho The Innovation Medicine.2025; 3(2): 100125. CrossRef
RALOX-HAIC (raltitrexed + oxaliplatin) combined with lenvatinib improves survival and safety in elderly patients with unresectable hepatocellular carcinoma Haohao Lu, Ya Gao, Xiangwen Xia, Qing Fu, Dongqiao Xiang BMC Cancer.2025;[Epub] CrossRef
Old Dogs Play New Tricks: Alpha-Fetoprotein Dynamics in the Era of GALAD Score Tung-Hung Su, Jia-Horng Kao Gastroenterology.2025; 169(1): 181. CrossRef
Roadmap for HCC Surveillance and Management in the Asia Pacific Masatoshi Kudo, Bui Thi Oanh, Chien-Jen Chen, Do Thi Ngat, Jacob George, Do Young Kim, Luckxawan Pimsawadi, Pisit Tangkijvanich, Raoh-Fang Pwu, Rosmawati Mohamed, Sakarn Bunnag, Sheng-Nan Lu, Sirintip Kudtiyakarn, Tatsuya Kanto, Teerha Piratvisuth, Chao-C Cancers.2025; 17(12): 1928. CrossRef
In Situ Vaccination with Poly-ICLC Combined with Systemic Nivolumab for the Treatment of Unresectable Hepatocellular Carcinoma Ja-Der Liang, Po-Chin Liang, Chia-Tung Shun, Chien-Hung Chen, Yao-Ming Wu, Yu-Chen Hsu, Ying-Te Lee, Pei-Ming Yang, Guan-Tarn Huang, Andres M Salazar, Hsuan-Shu Lee, Jin-Chuan Sheu, Meng-Tzu Weng Journal of Hepatocellular Carcinoma.2025; Volume 12: 1191. CrossRef
Dynamic profiles of early biological responses to predict the treatment efficacy of proton therapy in liver cancer assessed with in vivo kinetic [18F]-FDG PET/MRI Yi-Hsiu Chung, I-Chun Cho, Fujie Jhang, Chi-Chang Weng, Gigin Lin, Ching-Fang Yu, Fang-Hsin Chen Radiation Oncology.2025;[Epub] CrossRef
High Steatosis-Associated Fibrosis Estimator scores predict hepatocellular carcinoma in viral and non-viral hepatitis and metabolic dysfunction-associated steatotic liver disease Tung-Hung Su, Sheng-Shun Yang, Mei-Hsuan Lee, Wei-Yu Kao, Shang-Chin Huang, Fen-Fang Chen, Francis SK Poon, Lung-Wen Tsai, Yi-Ting Chen, Che Lin, Weichung Wang, W Ray Kim, Jia-Horng Kao Clinical and Molecular Hepatology.2025; 31(3): 796. CrossRef
Survival in patients with unresectable hepatocellular carcinoma: TCC cocktail plus TACE vs TACE alone prospective randomized clinical trial Jie Li, Bei Lv, Li Song, Xingxing Zhang, Jian Zhang, Xiaoyi Ding, Yongqiang Liu, Tao Ye, Mengzhou Guo, Tingting Fang, Biwei Yang, Zhiying Zhao, Peixin Huang, Yi Chen, Ningling Ge, Jinglin Xia Journal of Translational Medicine.2025;[Epub] CrossRef
Role of ALBI Grade as a Predictive Factor for Long‐Term Mortality in Patients With Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization Kyoung A Ko, Hyunwoo Oh, Myung Sub Kim, Hyun Pyo Hong, Yong Kyun Cho, Byung Ik Kim, Won Sohn Journal of Gastroenterology and Hepatology.2025; 40(11): 2758. CrossRef
Surgical treatment of hepatocellular carcinoma: an expert consensus-based practical recommendation from the Korean Liver Cancer Association Min-Su Park, Jai Young Cho, Eunju Kim, Hee Young Na, YoungRok Choi, Na Reum Kim, Young-In Yoon, Boram Lee, Eun Sun Jang, Yun Kyung Jung, Kyung Sik Kim Journal of Liver Cancer.2025; 25(2): 140. CrossRef
Surgical treatment of hepatocellular carcinoma: an expert consensus-based practical recommendation from the Korean Liver Cancer Association Min-Su Park, Jai Young Cho, Eunju Kim, Hee Young Na, YoungRok Choi, Na Reum Ki, Young-In Yoon, Boram Lee, Eun Sun Jang, Yun Kyung Jung, Kyung Sik Kim Annals of Surgical Treatment and Research.2025; 109(3): 123. CrossRef
Characterizing immune profiles in hepatocellular carcinoma patients benefiting from pembrolizumab and lenvatinib using machine learning Pei-Chang Lee, Po-Yu Li, Cheng-Yun Lee, Shian-Ren Lin, Chi-Jung Wu, Ya-Wen Hung, Yu-Hua Chen, Jun-Wen Chan, Hsien-Chen Mon, Chieh-Ju Lee, Chen-Ta Chi, I-Cheng Lee, Ming-Chih Hou, Yee Chao, Yi-Hsiang Huang, Jan-Mou Lee BMC Cancer.2025;[Epub] CrossRef
Latest advances in hepatocellular carcinoma management and prevention through advanced technologies Tamer A. Addissouky, Ibrahim El Tantawy El Sayed, Majeed M. A. Ali, Yuliang Wang, Ayman El Baz, Ahmed A. Khalil, Naglaa Elarabany Egyptian Liver Journal.2024;[Epub] CrossRef
Role of reimbursement and Physicians' awareness in the survival of sorafenib‐eligible advanced hepatocellular carcinoma patients Hui‐Ling Huang, Te‐Sheng Chang, Lariza Marie Canseco, Fan Wu, Sheng‐Nan Lu The Kaohsiung Journal of Medical Sciences.2024; 40(6): 589. CrossRef
Hemoglobin nanoclusters-mediated regulation of KPNA4 in hypoxic tumor microenvironment enhances photodynamic therapy in hepatocellular carcinoma Yiliang Wang, Nu Li, Letian Qu, Mu Zhang, Zhuo Li, Xiang Li, Dasheng Cai Journal of Nanobiotechnology.2024;[Epub] CrossRef
Application of a single-cell-RNA-based biological-inspired graph neural network in diagnosis of primary liver tumors Dao-Han Zhang, Chen Liang, Shu-Yang Hu, Xiao-Yong Huang, Lei Yu, Xian-Long Meng, Xiao-Jun Guo, Hai-Ying Zeng, Zhen Chen, Lv Zhang, Yan-Zi Pei, Mu Ye, Jia-Bin Cai, Pei-Xin Huang, Ying-Hong Shi, Ai-Wu Ke, Yi Chen, Yuan Ji, Yujiang Geno Shi, Jian Zhou, Jia F Journal of Translational Medicine.2024;[Epub] CrossRef
Targeting the p53-p21 axis in liver cancer: Linking cellular senescence to tumor suppression and progression Lakshmi Thangavelu, Abdulmalik S.A. Altamimi, Nehmat Ghaboura, M. Arockia Babu, R. Roopashree, Pawan Sharma, Pusparghya Pal, Chhavi Choudhary, G.V. Siva Prasad, Aashna Sinha, Ashok Kumar Balaraman, Sushama Rawat Pathology - Research and Practice.2024; 263: 155652. CrossRef
Expression and diagnostic value of abnormal prothrombin and osteopontin in hepatocellular carcinoma with cirrhosis Guanjun Li American Journal of Translational Research.2024; 16(9): 4688. CrossRef
Calpain 2 promotes Lenvatinib resistance and cancer stem cell traits via both proteolysis-dependent and independent approach in hepatocellular carcinoma Xiaolu Ma, Kaixia Zhou, Tianqing Yan, Ling Hu, Suhong Xie, Hui Zheng, Ying Tong, Heng Zhang, Yanchun Wang, Zhiyun Gong, Cuncun Chen, Yanan Tian, Lin Guo, Renquan Lu Molecular Biomedicine.2024;[Epub] CrossRef
Efficacy of transcatheter arterial chemoembolization combined with radiotherapy for locally advanced hepatocellular carcinoma Lihua Liao American Journal of Translational Research.2024; 16(11): 6935. CrossRef
Clinical practice guidelines and real-world practice for hepatocellular carcinoma in Taiwan: Bridging the gap Shen-Yung Wang Clinical and Molecular Hepatology.2023; 29(2): 349. CrossRef
Overview of Asian clinical practice guidelines for the management of hepatocellular carcinoma: An Asian perspective comparison Yuri Cho, Bo Hyun Kim, Joong-Won Park Clinical and Molecular Hepatology.2023; 29(2): 252. CrossRef
Challenges in translating clinical guidelines into real-life practice for management of hepatocellular carcinoma in Taiwan San-Chi Chen Clinical and Molecular Hepatology.2023; 29(2): 352. CrossRef
Viral Status and Treatment Efficacy in Recurrent Hepatocellular Carcinoma After Primary Resection Hou-Ying Cheng, Rey-Heng Hu, Chih-Yang Hsiao, Ming-Chih Ho, Yao-Ming Wu, Po-Huang Lee, Cheng-Maw Ho Journal of Gastrointestinal Surgery.2023; 27(8): 1594. CrossRef
A bibliometric study on the utilization of lenvatinib in hepatocellular carcinoma (2014–2022) Cong-Cong Wang, Cai-Yan Yu, Jing Zhang, Rui Wang, Xiang-Shuo Kong Frontiers in Pharmacology.2023;[Epub] CrossRef
Friend or Foe? Locoregional Therapies and Immunotherapies in the Current Hepatocellular Treatment Landscape Shamar Young, Jack Hannallah, Dan Goldberg, Tina Sanghvi, Junaid Arshad, Aaron Scott, Gregory Woodhead International Journal of Molecular Sciences.2023; 24(14): 11434. CrossRef
Inhibition of Dickkopf-1 enhances the anti-tumor efficacy of sorafenib via inhibition of the PI3K/Akt and Wnt/β-catenin pathways in hepatocellular carcinoma Sang Hyun Seo, Kyung Joo Cho, Hye Jung Park, Hye Won Lee, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Jae Hee Cheon, Jong In Yook, Man-Deuk Kim, Dong Jin Joo, Seung Up Kim Cell Communication and Signaling.2023;[Epub] CrossRef
Background/Aims Real-world studies assessing the effectiveness and safety of sofosbuvir/velpatasvir (SOF/VEL) plus ribavirin (RBV) for Child-Pugh B/C hepatitis C virus (HCV)-related cirrhosis are limited.
Methods We included 107 patients with Child-Pugh B/C HCV-related cirrhosis receiving SOF/VEL plus RBV for 12 weeks in Taiwan. The sustained virologic response rates at off-treatment week 12 (SVR12) for the evaluable population (EP), modified EP, and per-protocol population (PP) were assessed. Thesafety profiles were reported.
Result s: The SVR12 rates in the EP, modified EP and PP were 89.7% (95% confidence interval [CI], 82.5–94.2%), 94.1% (95% CI, 87.8–97.3%), and 100% (95% CI, 96.2–100%). Number of patients who failed to achieve SVR12 were attributed to virologic failures. The SVR12 rates were comparable regardless of patient characteristics. One patient discontinued treatment because of adverse events (AEs). Twenty-four patients had serious AEs and six died, but none were related to SOF/VEL or RBV. Among the 96 patients achieving SVR12, 84.4% and 64.6% had improved Child-Pugh and model for endstage liver disease (MELD) scores. Multivariate analysis revealed that a baseline MELD score ≥15 was associated with an improved MELD score of ≥3 (odds ratio, 4.13; 95% CI, 1.16–14.71; P=0.02). Patients with chronic kidney disease (CKD) stage 1 had more significant estimated glomerular filtration rate declines than patients with CKD stage 2 (-0.42 mL/min/1.73 m2/month; P=0.01) or stage 3 (-0.56 mL/min/1.73 m2/month; P<0.001).
Conclusions SOF/VEL plus RBV for 12 weeks is efficacious and well-tolerated for Child-Pugh B/C HCV-related cirrhosis.
Citations
Citations to this article as recorded by
2025 KASL clinical practice guidelines for management of hepatitis C Eun Sun Jang, Nae Yun Heo, Jae Yoon Jeong, Jung Gil Park, Do Seon Song, Eun Ju Cho, Chang Hun Lee, Jae Seung Lee, Jae Hyun Yoon, Seul Ki Han, Young Kul Jung Clinical and Molecular Hepatology.2026; 32(1): 1. CrossRef
Role of etiological therapy in achieving recompensation of decompensated liver cirrhosis Dmitry V Garbuzenko World Journal of Hepatology.2025;[Epub] CrossRef
Effectiveness of etiotropic therapy in achieving recompensation of cirrhosis D.V. Garbuzenco Russian Journal of Evidence-Based Gastroenterology.2025; 14(2): 68. CrossRef
Real-World Treatment Efficacy and Safety Profile of Sofosbuvir- and Velpatasvir-Based HCV Treatment in South Korea: Multicenter Prospective Study Jae Hyun Yoon, Chang Hun Lee, Hoon Gil Jo, Ju-Yeon Cho, Jin Dong Kim, Jin Won Kim, Ga Ram You, Sung Bum Cho, Sung Kyu Choi Viruses.2025; 17(7): 949. CrossRef
Efficacy and Safety of Velpatasvir Plus Sofosbuvir With or Without Ribavirin in Hepatitis C Patients With Decompensated Cirrhosis: A Systematic Review and Meta‐Analysis Jing Xiao, Xinnian Zhang, Xiaozhou Mao, Shunhao Lai, Shuangli Li, Yunjian Sheng Journal of Viral Hepatitis.2025;[Epub] CrossRef
Oral carbohydrate intake before selective laparoscopic liver resection reduces insulin resistance and enhances recovery Hongqiong Li American Journal of Translational Research.2025; 17(8): 6080. CrossRef
Recent Advances in the Treatment of Chronic Hepatitis C Suk Bae Kim The Korean Journal of Gastroenterology.2025; 85(4): 475. CrossRef
Five-year follow-up of sustained virological response with hepatitis C infection after direct-acting antiviral therapy: A single-center retrospective study Mengyue Li, Yiting Li, Ying Zhang, Xiangyang Wang, Chaoshuang Lin Medicine.2024; 103(7): e37212. CrossRef
Cutting-edge pharmacotherapy for hepatitis C virus infection: a comprehensive review Chen-Hua Liu, Yu-Ping Chang, Jia-Horng Kao Expert Opinion on Pharmacotherapy.2024; 25(12): 1691. CrossRef
Real-life study on the effectiveness and safety of sofosbuvir/velpatasvir-based antiviral agents for hepatitis C eradication in Chinese patients Jiayi Wang, Lingyao Du, Dongmei Zhang, Chen Zhou, Yilan Zeng, Miao Liu, Xing Cheng, Xiaona Song, Han Chen, Ning Han, Enqiang Chen, Hong Tang Journal of Virus Eradication.2024; 10(4): 100571. CrossRef
Sofosbuvir/velpatasvir or glecaprevir/pibrentasvir for treating patients with hepatitis C virus reinfection following direct‐acting antiviral‐induced sustained virologic response Chen‐Hua Liu, Chun‐Jen Liu, Tung‐Hung Su, Tai‐Chung Tseng, Pei‐Jer Chen, Jia‐Horng Kao Advances in Digestive Medicine.2023; 10(1): 34. CrossRef
Changes in renal function in patients with chronic hepatitis C treated with sofosbuvir‐velpatasvir Pei‐Kai Su, Te‐Sheng Chang, Shui‐Yi Tung, Kuo‐Liang Wei, Chien‐Heng Shen, Yung‐Yu Hsieh, Wei‐Ming Chen, Yi‐Hsing Chen, Chun‐Hsien Chen, Chih‐Wei Yen, Huang‐Wei Xu, Wei‐Ling Tung, Kao‐Chi Chang Advances in Digestive Medicine.2023; 10(3): 150. CrossRef
Response to antiviral therapy for chronic hepatitis C and risk of hepatocellular carcinoma occurrence in Japan: a systematic review and meta-analysis of observational studies Yoko Yamagiwa, Keitaro Tanaka, Keitaro Matsuo, Keiko Wada, Yingsong Lin, Yumi Sugawara, Tetsuya Mizoue, Norie Sawada, Hidemi Takimoto, Hidemi Ito, Tetsuhisa Kitamura, Ritsu Sakata, Takashi Kimura, Shiori Tanaka, Manami Inoue, Sarah Krull Abe, Shuhei Nomur Scientific Reports.2023;[Epub] CrossRef
Efficacy and safety of sofosbuvir–velpatasvir and sofosbuvir–velpatasvir–voxilaprevir for hepatitis C in Korea: a Phase 3b study Jeong Heo, Yoon Jun Kim, Sung Wook Lee, Youn-Jae Lee, Ki Tae Yoon, Kwan Soo Byun, Yong Jin Jung, Won Young Tak, Sook-Hyang Jeong, Kyung Min Kwon, Vithika Suri, Peiwen Wu, Byoung Kuk Jang, Byung Seok Lee, Ju-Yeon Cho, Jeong Won Jang, Soo Hyun Yang, Seung W The Korean Journal of Internal Medicine.2023; 38(4): 504. CrossRef
Efficacy and Safety of Sofosbuvir/Velpatasvir Plus Ribavirin in Patients with Hepatitis C Virus-Related Decompensated Cirrhosis Steven Flamm, Eric Lawitz, Brian Borg, Michael Charlton, Charles Landis, K. Rajender Reddy, Mitchell Shiffman, Angel Alsina, Charissa Chang, Natarajan Ravendhran, Candido Hernandez, Christophe Hézode, Stacey Scherbakovsky, Renee-Claude Mercier, Didier Sam Viruses.2023; 15(10): 2026. CrossRef
Sofosbuvir-based direct-acting antivirals for patients with decompensated hepatitis C virus–related cirrhosis Chen-Hua Liu, Chun-Jen Liu, Jia-Horng Kao Journal of the Chinese Medical Association.2022; 85(5): 647. CrossRef
Real-life experience of ledipasvir and sofosbuvir for HCV infected Korean patients: a multicenter cohort study Soon Kyu Lee, Sung Won Lee, Hae Lim Lee, Hee Yeon Kim, Chang Wook Kim, Do Seon Song, U Im Chang, Jin Mo Yang, Sun Hong Yoo, Jung Hyun Kwon, Soon Woo Nam, Seok-Hwan Kim, Myeong Jun Song, Jaejun Lee, Hyun Yang, Si Hyun Bae, Ji Won Han, Heechul Nam, Pil Soo The Korean Journal of Internal Medicine.2022; 37(6): 1167. CrossRef
HCV Infection and Liver Cirrhosis Are Associated with a Less-Favorable Serum Cholesteryl Ester Profile Which Improves through the Successful Treatment of HCV Kilian Weigand, Georg Peschel, Jonathan Grimm, Martina Müller, Marcus Höring, Sabrina Krautbauer, Gerhard Liebisch, Christa Buechler Biomedicines.2022; 10(12): 3152. CrossRef
First
Prev
