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ORIGINAL ARTICLES  
CMH 2012 September;18:295-301.
Published online 2012 September 26. doi:http://dx.doi.org/10.3350/cmh.2012.18.3.295
Copyright © 2012 The Korean Association for the Study of the Liver
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Association between apolipoprotein E genotype, chronic liver disease, and hepatitis B virus
Seun Joo Ahn, Dong Kyu Kim, Soon Sun Kim, Chang Bum Bae, Hyo Jung Cho, Han Gyeol Kim, Young Jip Kim, Joo Ho Lee, Hyo Jin Lee, Mi Yeon Lee, Kee Bum Kim, Jin Hee Cho, Sung Won Cho, Jae Youn Cheong
Department of Gastroenterology, Genomic Research Center for Gastroenterology, Ajou University School of Medicine, Suwon, Korea
Corresponding Author: Jae Youn Cheong ,Tel: +82-31-219-5119, Fax: +82-31-219-5999, Email: jaeyoun620@gmail.com
ABSTRACT
Background/Aims: Apolipoprotein E (ApoE) plays an important role in regulating lipid and lipoprotein metabolism, and ApoE genotypes are known to affect plasma lipoprotein concentrations. We investigated whether ApoE genotype determines the disease outcome in hepatitis B virus (HBV)-infected individuals, and verified the association between ApoE genotype and the occurrence of hepatocellular carcinoma (HCC) in patients with chronic liver diseases of various etiologies.
Methods: This hospital-based, case-controlled study enrolled 156 subjects (47 healthy controls, 50 HBV-related liver cirrhosis patients, and 59 HCC patients). ApoE genotypes were determined using PCR-based ApoE genotyping kits. The biological significance of ApoE genotype was verified by measuring serum ApoE levels using an ELISA kits.
Results: The ュ3 allele was the most common allele, with allele frequencies among the entire cohort of 5.8%, 84.3%, and 9.9% for the ュ2, ュ3, and ュ4 alleles, respectively. Significantly more of those patients carrying the ュ3/3 genotype had developed liver cirrhosis compared to the control subjects. Being an ApoE4 carrier was associated with a lower probability of developing liver cirrhosis. The allele frequencies and genotype distribution of ApoE did not differ significantly between the liver cirrhosis and HCC patients. The serum level of ApoE was significantly higher in patients with liver cirrhosis than in the healthy controls, but did not differ significantly with the ApoE genotype.
Conclusions: The ApoE ュ3/3 genotype frequency was higher in patients with HBV-associated liver cirrhosis than in the controls.
Keywords: Apolipoprotein E; Hepatitis B virus; Genotype; Liver cirrhosis
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