Advanced Search
CMH 2008 June;14:178-184.
Published online 2000 January 01. doi:
Copyright © 2008 The Korean Association for the Study of the Liver
  |  Abstract   |  PDF Links PDF Links   |   Download Citation
Clinical feature of Fitz-Hugh-Curtis syndrome: Analysis of 25 cases
Hyeon Woong Yang, M.D., Sung Hee Jung, M.D., Hyun Young Han1, Anna Kim, M.D., Yun Jung Lee, M.D., Sang Woo Cha, M.D., Hun Go, M.D., Gi Young Choi, M.D., Soung Hoon Cho, M.D., Sin Hyung Lim, M.D.
Department of Internal Medicine, 1Department of Radiology, Eulji University College of Medicine, Eulji University Hospital, Daejeon, Korea
Background/Aims: Fitz-Hugh-Curtis syndrome is defined as perihepatitis associated with pelvic inflammatory disease (PID). We retrospectively analyzed clinical and laboratory manifestations as well as the therapeutic response in patients with clinically diagnosed Fitz-Hugh-Curtis syndrome. Methods: A cohort of 25 patients with PID and perihepatitis (as diagnosed by dynamic abdominal computed tomography (CT)) was enrolled. The prognosis, clinical manifestations, and physical examination, laboratory, and CT findings were analyzed. Results: The mean (SD) age of the patients was 32(8) years, and all of them were sexually active, premenopausal women, and presented with abdominal pain. Of these, 52% complained of vaginal discharge. On physical examination, right upper-quadrant tenderness was the most common finding (84%), with lower-abdominal tenderness being present in 20% of patients. On laboratory examination, erythrocyte sedimentation rate and C-reactive protein were increased in 76% and 92% of the patients, respectively. The white blood cell count was increased in 60% of them. Most patients had a normal liver function test. Using a specimen of the cervical discharge, the polymerase chain reaction to test for Chlamydia trachomatis were positive in 87% (13/15) of the patients, and Chlamydia antigen was found in 75% (9/12) of them. Dynamic abdominal CT revealed subcapsular enhancement of the liver in the arterial phase. All of the patients improved with antibiotic therapy. Conclusions: Symptoms and physical findings suggestive of PID are not present in many patients with Fitz-Hugh-Curtis syndrome. When a premenopausal woman complains of upper abdominal pain and shows CT findings compatible with perihepatitis, examination of cervical discharge would be recommended to assess the possibility of Fitz-Hugh-Curtis syndrome. (Korean J Hepatol 2008;14:178-184)
Keywords: Fitz-Hugh-Curtis syndrome; Perihepatitis; Pelvic inflammatory disease; Chlamydia trachomatis
Don't forget to sign up for journal e-mail alerts so you can keep up to date with all the articles as they are published.
vol: Issue: Page:
Author's home
Reviewer's home
Editor's home
The Korean Association for the Study of the Liver
PubMed Central
Register for e-submission
Register here to access the e-submission system of CMH for authors and reviewers.
Manuscript Submission
To submit a manuscript, please visit the CMH e-submission management system at, read the Instructions for Authors, and log into the CMH e-submission system. For assistance with manuscript submission, please contact:
Free archive
Anyone may access any past or current articles without logging in.
The Korean Association for the Study of the Liver
Room A1210, 53 Mapo-daero(MapoTrapalace, Dowha-dong), Mapo-gu, Seoul, 04158, Korea
TEL : +82-2-703-0051    FAX : +82-2-703-0071   E-mail :
Copyright © By The Korean Association for the Study of the Liver. All right reserved.